公开(公告)号：WO2005066166A3

公开(公告)日：2005-09-01

申请号：PCT/US2004041366

申请日：2004-12-10

Applicant: ABBOTT LAB ,  JI JIANGUO ,  LI TAO ,  WANG YING

Inventor： JI JIANGUO ,  LI TAO ,  WANG YING

IPC: A61K31/439 ,  C07D453/00 ,  C07D453/02 ,  A61P25/00

CPC classification number: C07D453/02

Abstract: Compounds of formula (I); wherein A is N or N -O ; n is 0, 1, or 2; Y is O, S, -NH-, and -N-alkyl-; Ar is both 6-membered aromatic rings; Ar is 5- or 6-membered aromatic rings with a -NR R group, as defined herein. The compounds are useful in treating conditions or disorders prevented by or ameliorated by alpha7 nAChR ligands. Also disclosed are pharmaceutical compositions having compounds of formula (I) and methods for using such compounds and compositions.

Abstract translation: 式（I）化合物; 其中A是N或N + -O-; n是0,1或2; Y是O，S，-NH-和-N-烷基 - ; Ar 1均为6元芳族环; Ar 2是如本文所定义的具有-NR 8 R 9基团的5或6元芳族环。 这些化合物可用于治疗由α7nAChR配体预防或改善的病症或障碍。 还公开了具有式（I）化合物的药物组合物和使用这些化合物和组合物的方法。

公开(公告)号：WO2010124042A3

公开(公告)日：2011-02-03

申请号：PCT/US2010031974

申请日：2010-04-22

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG ,  WANG YING ,  BREWER JASON T ,  AKRITOPOULOU-ZANZE IRINI ,  DJURIC STEVAN W ,  POHLKI FRAUKE ,  BRAJE WILFRIED ,  RELO ANA-LUCIA

Inventor： WANG YING ,  BREWER JASON T ,  AKRITOPOULOU-ZANZE IRINI ,  DJURIC STEVAN W ,  POHLKI FRAUKE ,  BRAJE WILFRIED ,  RELO ANA-LUCIA

IPC: C07D498/04 ,  A61K31/4985 ,  A61K31/551 ,  A61K31/553 ,  A61P25/00 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D491/04

CPC classification number: C07D498/04 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D491/04

Abstract: The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

Abstract translation: 本申请涉及1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1,4]苯并二氮杂，1,2,3,4,4a， 7-八氢吡嗪并[1,2-a] [1,5]苯并二氮杂，2,3,4,4a，5,6,7,11b-八氢-1H-吡啶并[3,4-d] [2]苯并氮杂， 1,2,3,4,4a，5,6,7-八氢吡嗪并[1,2-a] [1]苯并氮杂，1,2,3,4,4a，5-六氢-7H-吡嗪并[1,2 -a] [4,1]苯并氧氮杂和2,3,4,4a，5,6-六氢-1H-吡嗪并[2,1-d] [1,5]苯并氧氮杂和5,6,7,7a ，其中R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 5，R 6， X1，X2，X3，X4，Y1，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。

公开(公告)号：WO2008002956A3

公开(公告)日：2008-07-03

申请号：PCT/US2007072185

申请日：2007-06-27

Applicant: ABBOTT LAB ,  FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  EL KOUHEN RACHID ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

IPC: C07D417/04 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D417/14

CPC classification number: C07D417/04 ,  C07D413/04 ,  C07D417/14

Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.

Abstract translation: 本发明涉及选自化合物的式I化合物。 式（I）化合物在治疗由烟碱乙酰胆碱受体调节的病症和病症中。

公开(公告)号：CA2759607A1

公开(公告)日：2010-10-28

申请号：CA2759607

申请日：2010-04-22

Applicant: ABBOTT GMBH & CO KG ,  ABBOTT LAB

Inventor： WANG YING ,  BREWER JASON T ,  AKRITOPOULOU-ZANZE IRINI ,  DJURIC STEVAN W ,  POHLKI FRAUKE ,  BRAJE WILFRIED ,  RELO ANA-LUCIA

IPC: C07D498/04 ,  A61K31/4985 ,  A61K31/551 ,  A61K31/553 ,  A61P25/00 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D491/04

Abstract: The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：MXPA06007180A

公开(公告)日：2006-09-04

申请号：MXPA06007180

申请日：2004-12-10

Applicant: ABBOTT LAB

Inventor： WANG YING

IPC: A61K31/439 ,  A61P25/00 ,  C07D453/00 ,  C07D453/02

Abstract: Se describe un compuesto de formula (I); (ver formula (I)) en donde A es N o N+-O-; n es 0, 1 o 2; Y es O, S, -NH-, y N-alquilo; Ar1 son anillos aromaticos de 6 miembros; Ar2 son anillos aromaticos de 5- o 6-miembros con un grupo -NH8R9, como se define en la presente. Los compuestos son utiles en el tratamiento de condiciones o trastornos para ser prevenidos por o mejorase por los ligandos de nAChR (7. Tambien se describen composiciones farmaceuticas que tienen compuestos de formula (I) y metodos para utilizar tales compuestos y composiciones.

公开(公告)号：CA2549976A1

公开(公告)日：2005-07-21

申请号：CA2549976

申请日：2004-12-10

Applicant: ABBOTT LAB

Inventor： WANG YING ,  LI TAO ,  JI JIANGUO

IPC: C07D453/00 ,  A61K31/439 ,  A61P25/00 ,  C07D453/02

Abstract: Compounds of formula (I); wherein A is N or N+-O-; n is 0, 1, or 2; Y is O, S, -NH-, and -N-alkyl-; Ar1 is both 6-membered aromatic rings; Ar2 is 5- or 6- membered aromatic rings with a -NR8R9 group, as defined herein. The compound s are useful in treating conditions or disorders prevented by or ameliorated b y .alpha.7 nAChR ligands. Also disclosed are pharmaceutical compositions havin g compounds of formula (I) and methods for using such compounds and compositio ns.

公开(公告)号：MX2008016336A

公开(公告)日：2009-01-16

申请号：MX2008016336

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： FAGHIH RAMIN ,  GFESSER GREGORY A ,  LYNCH CHRISTOPHER L ,  GOPALAKRISHNAN MURALI ,  GOPALAKRISHNAN SUJATHA ,  MALYSZ JOHN ,  GUBBINS EARL J ,  KOUHEN RACHID EL ,  LI JINHE ,  SARRIS KATHY A ,  MICHMERHUIZEN MELISSA J ,  WANG YING

IPC: C07D417/04 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D417/14

Abstract: La invención se refiere a una serie de derivados de tiazolina y oxazolina, composiciones de los mismos, y métodos para tratar condiciones y trastornos utilizando dichos compuestos.

公开(公告)号：MX2011011182A

公开(公告)日：2012-02-21

申请号：MX2011011182

申请日：2010-04-22

Applicant: ABBOTT LAB

Inventor： DJURIC STEVAN W ,  BRAJE WILFRIED ,  WANG YING ,  BREWER JASON T ,  AKRITOPOULOUZANZE IRINI ,  POHLKI FRAUKE ,  RELO ANA-LUCIA

IPC: C07D498/04 ,  A61K31/4985 ,  A61K31/551 ,  A61K31/553 ,  A61P25/00 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D491/04

Abstract: La presente solicitud se refiere a derivados de 1,2,3,4,4a,5,6,7-octahidropirazino[1,2-a][1,4]benzodiazepina, 1,2,3,4,4a,5,6,7-octahidropirazino[1,2-a][1,5]benzodiazepina, 2,3,4,4a,5,6,7,11b-octahidro-1H-pirido[3,4-d][2]benzazepina, 1,2,3,4,4a,5,6,7-octahidropirazino[1,2-aJ[1]benzazepina, 1,2,3,4,4a,5-hexahidro-7H-pirazino[1,2-a][4,1]benzoxazepina, y 2,3,4,4a,5,6-hexahidro-1H-pirazino[2,1-d][1,5]benzoxazepina, y 5,6,7,7a,8,9,10,11-octahidropirazino[1,2-d]pirido[3,2-b][1,4]diaz epina de la fórmula (I) en la cual R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, y Y3 son como se definen en la descripción. La presente solicitud también se refiere a composiciones que comprenden dichos compuestos, y a métodos para tratar condiciones patológicas utilizando dichos compuestos y composiciones, y a métodos para identificar dichos compuestos.

公开(公告)号：CA2659762A1

公开(公告)日：2008-01-03

申请号：CA2659762

申请日：2007-06-27

Applicant: ABBOTT LAB

Inventor： GOPALAKRISHNAN SUJATHA ,  EL KOUHEN RACHID ,  SARRIS KATHY A ,  LI JINHE ,  MALYSZ JOHN ,  GUBBINS EARL J ,  GOPALAKRISHNAN MURALI ,  WANG YING ,  MICHMERHUIZEN MELISSA J ,  LYNCH CHRISTOPHER L ,  GFESSER GREGORY A ,  FAGHIH RAMIN

IPC: C07D417/04 ,  A61K31/422 ,  A61K31/427 ,  C07D413/04 ,  C07D417/14

Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are r egulated by the nicotinic acetylcholine receptors.