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公开(公告)号：WO2008002956A3
公开(公告)日：2008-07-03
申请号：PCT/US2007072185
申请日：2007-06-27
Applicant: ABBOTT LAB , FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
Inventor： FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , EL KOUHEN RACHID , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
IPC: C07D417/04 , A61K31/422 , A61K31/427 , C07D413/04 , C07D417/14
CPC classification number: C07D417/04 , C07D413/04 , C07D417/14
Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are regulated by the nicotinic acetylcholine receptors.
Abstract translation: 本发明涉及选自化合物的式I化合物。 式（I）化合物在治疗由烟碱乙酰胆碱受体调节的病症和病症中。
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公开(公告)号：MX2009013213A
公开(公告)日：2010-03-30
申请号：MX2009013213
申请日：2008-06-04
Applicant: ABBOTT LAB
Inventor： KALVIN DOUGLAS M , WANG LU , GASIECKI ALAN F , GRACIAS VIJAYA J , AKRITOPOULOU-ZANZE IRINI , LI BIQIN , PATEL JYOTI R , SHUAI QI , TURNER SEAN C , DJURIC STEVAN W , BAKKER MARGARETHA , VASUDEVAN ANIL , MICHMERHUIZEN MELISSA J , SARRIS KATHY , HOBSON ADRIAN , TEUSCH NICOLE , MACK HELMUT , WAKEFIELD BRIAN D , JOHNSON ERIC T , KOVAR PETER J , LONG ANDREW J , MOORE NIGEL ST JOHN , GEORGE DAWN , FRANK KRISTINE
IPC: C07D403/04 , C07D413/04 , C07D417/04
Abstract: La presente invención se refiere a compuestos de la fórmula (I) o sales farmacéuticamente aceptables, en donde A, R1, R2, R3 y m, son como se definieron en la descripción. La presente invención se refiere también a métodos para elaborar los compuestos, y composiciones que contienen los compuestos los cuales son útiles para inhibir las cinasas tales como Glicógeno Cintaza cinasa 3 (GSK-3), Rho cinasa (ROCK), Janus Cinasas (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 y nek 2.
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公开(公告)号：CA2659762A1
公开(公告)日：2008-01-03
申请号：CA2659762
申请日：2007-06-27
Applicant: ABBOTT LAB
Inventor： GOPALAKRISHNAN SUJATHA , EL KOUHEN RACHID , SARRIS KATHY A , LI JINHE , MALYSZ JOHN , GUBBINS EARL J , GOPALAKRISHNAN MURALI , WANG YING , MICHMERHUIZEN MELISSA J , LYNCH CHRISTOPHER L , GFESSER GREGORY A , FAGHIH RAMIN
IPC: C07D417/04 , A61K31/422 , A61K31/427 , C07D413/04 , C07D417/14
Abstract: The invention relates to compounds of formula I selected from compounds. The compounds of formula (I) in treating conditions and disorders that are r egulated by the nicotinic acetylcholine receptors.
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公开(公告)号：ZA200908624B
公开(公告)日：2015-08-26
申请号：ZA200908624
申请日：2009-12-04
Applicant: ABBOTT LAB , ABBOTT GMBH & CO KG
Inventor： FRANK KRISTINE , GEORGE DAWN , ST JOHN MOORE NIGEL , VASUDEVAN ANIL , LONG ANDREW J , KOVAR PETER J , JOHNSON ERIC T , TEUSCH NICOLE , BAKKER MARGARETHA , MICHMERHUIZEN MELISSA J , KALVIN DOUGLAS M , SARRIS KATHY , GRACIAS VIJAYA J , GASIECKI ALAN F , WAKEFIELD BRIAN D , AKRITOPOULOU-ZANZE IRINI , HOBSON ADRIAN D , WANG LU , PATEL JYOTI R , SHUAI QI , TURNER SEAN C , DJURIC STEVAN W , MACK HELMUT , LI BIQIN
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公开(公告)号：CY1110361T1
公开(公告)日：2015-04-29
申请号：CY071101364
申请日：2007-10-23
Applicant: ABBOTT LAB
Inventor： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC: C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: ΗπαρούσαεφεύρεσησχετίζεταιμεενώσειςτουτύπουΙ οιοποίεςαναστέλλουντηνδιπεπτιδυλικήπεπτιδάση IV (DPP-IV) καιείναιχρήσιμεςγιατηνπρόληψηή τηναγωγήτουδιαβήτη, ειδικάτουδιαβήτητύπουΙΙ, όπωςεπίσηςτηςυπεργλυκαιμίας, τουΣυνδρόμουΧ, τηςυπερινσουλιναιμίας, τηςπαχυσαρκίας, τηςαθηροσκλήρωσης, καιδιαφόρωνανοσορρυθμιστικώννόσων. Ήφαρμακευτικώςαποδεκτάάλαταή προφάρμακααυτών, όπουτα X, R, R1, R2 και R3 έχουντουςορισμούςπουδίνονταιστηνπεριγραφή.
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Patent Agency Ranking
公开(公告)号：SG182187A1
公开(公告)日：2012-07-30
申请号：SG2012043113
申请日：2008-06-04
Applicant: ABBOTT GMBH & CO KG , ABBOTT LAB
Inventor： AKRITOPOULOU-ZANZE IRINI , WAKEFIELD BRIAN D , MACK HELMUT , TURNER SEAN C , GASIECKI ALAN F , GRACIAS VIJAYA J , SARRIS KATHY , KALVIN DOUGLAS M , MICHMERHUIZEN MELISSA J , SHUAI QI , PATEL JYOTI R , BAKKER MARGARETHA , TEUSCH NICOLE , KOVAR PETER J , DJURIC STEVAN W , LONG ANDREW J , VASUDEVAN ANIL , HOBSON ADRIAN , ST JOHN MOORE NIGEL , WANG LU , GEORGE DAWN , LI BIQIN , FRANK KRISTINE , JOHNSON ERIC T
Abstract: 5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORSAbstractThe present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein A, R1,R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Ala, PAK4, PLK, CK2, KDR, MK2, JNK I, aurora, pim I and nek 2.No suitable figure
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公开(公告)号：DE60315336T2
公开(公告)日：2008-05-08
申请号：DE60315336
申请日：2003-09-15
Applicant: ABBOTT LAB
Inventor： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC: C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.
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公开(公告)号：MX2008016336A
公开(公告)日：2009-01-16
申请号：MX2008016336
申请日：2007-06-27
Applicant: ABBOTT LAB
Inventor： FAGHIH RAMIN , GFESSER GREGORY A , LYNCH CHRISTOPHER L , GOPALAKRISHNAN MURALI , GOPALAKRISHNAN SUJATHA , MALYSZ JOHN , GUBBINS EARL J , KOUHEN RACHID EL , LI JINHE , SARRIS KATHY A , MICHMERHUIZEN MELISSA J , WANG YING
IPC: C07D417/04 , A61K31/422 , A61K31/427 , C07D413/04 , C07D417/14
Abstract: La invención se refiere a una serie de derivados de tiazolina y oxazolina, composiciones de los mismos, y métodos para tratar condiciones y trastornos utilizando dichos compuestos.
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公开(公告)号：DK1560811T3
公开(公告)日：2007-12-10
申请号：DK03774478
申请日：2003-09-15
Applicant: ABBOTT LAB
Inventor： MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SHAM HING L , STEWART KENT D , SZCZEPANKIEWICZ BRUCE G
IPC: C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
Abstract: The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R ,R and R have the definitions given in the description.
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公开(公告)号：PT1560811E
公开(公告)日：2007-11-14
申请号：PT03774478
申请日：2003-09-15
Applicant: ABBOTT LAB
Inventor： STEWART KENT D , SHAM HING L , MADAR DAVID , PEI ZHONGHUA , PIREH DAISY , DJURIC STEVAN W , WIEDEMAN PAUL E , YONG HONG , MICHMERHUIZEN MELISSA J , KOPECKA HANA , LI XIAOFENG , LONGENECKER KENTON , SZCZEPANKIEWICZ BRUCE G
IPC: C07D207/00 , A61P37/02 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
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