公开(公告)号：WO2004100868A2

公开(公告)日：2004-11-25

申请号：PCT/US2004012456

申请日：2004-04-23

Applicant: ABBOTT LAB ,  WAEGELL WENDY ,  HIRST GAVIN

Inventor： WAEGELL WENDY ,  HIRST GAVIN

IPC: A61K20060101 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K38/13 ,  A61K38/40 ,  A61K39/395 ,  A61P37/06 ,  A61K

CPC classification number: A61K45/06

Abstract: This invention relates to a method of treating transplant rejection comprising administering to a patient a pharmaceutical composition comprising an lck inhibitor and a calcineurin inhibitor or an immunosuppressant.

Abstract translation: 本发明涉及一种治疗移植排斥的方法，包括向患者施用包含耐低温抑制剂和钙调磷酸酶抑制剂或免疫抑制剂的药物组合物。

公开(公告)号：AT419253T

公开(公告)日：2009-01-15

申请号：AT04779180

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW ,  CALDERWOOD DAVID ,  CURTIN MICHAEL ,  DAVIDSEN STEVEN ,  DAVIS HEATHER ,  FREY ROBIN ,  HEYMAN HOWARD ,  HIRST GAVIN ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL ,  MUCKEY MELANIE ,  RAFFERTY PAUL ,  WADA CAROL

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.