公开(公告)号：WO2008005368A2

公开(公告)日：2008-01-10

申请号：PCT/US2007015192

申请日：2007-06-29

Applicant: ABBOTT LAB ,  BETSCHMANN PATRICK ,  CARROLL WILLIAM A ,  ERICSSON ANNA M ,  FIX-STENZEL SHANNON R ,  FRIEDMAN MICHAEL ,  HIRST GAVIN C ,  JOSEPHSOHN NATHAN S ,  LI BIQIN ,  PEREZ-MEDRANO ARTURO ,  MORYTKO MICHAEL J ,  RAFFERTY PAUL ,  CHEN HAIPENG

Inventor： BETSCHMANN PATRICK ,  CARROLL WILLIAM A ,  ERICSSON ANNA M ,  FIX-STENZEL SHANNON R ,  FRIEDMAN MICHAEL ,  HIRST GAVIN C ,  JOSEPHSOHN NATHAN S ,  LI BIQIN ,  PEREZ-MEDRANO ARTURO ,  MORYTKO MICHAEL J ,  RAFFERTY PAUL ,  CHEN HAIPENG

IPC: A61K31/496

CPC classification number: C07D241/04 ,  C07D241/36 ,  C07D295/215 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I), wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract translation: 式（I）的新型化合物或其药学上可接受的盐，其代谢物，其异构体，其对映异构体或其前体药物，其中取代基如本文所定义，其可用作治疗剂。

公开(公告)号：DK1648905T3

公开(公告)日：2009-03-30

申请号：DK04779180

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：CA2560691A1

公开(公告)日：2005-10-13

申请号：CA2560691

申请日：2005-03-24

Applicant: MAKOTO AOYAMA ,  ABBOTT LAB

Inventor： WADA CAROL K ,  STEINMAN DOUGLAS H ,  RAFFERTY PAUL ,  MAKOTO AOYAMA ,  XIA ZHIREN ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  DINGES JUERGEN ,  HOLMS JAMES H ,  ZHANG HENRY Q ,  AKRITOPOULOU-ZANZE IRINI ,  DIXON RICHARD W ,  DJURIC STEVAN W ,  ERICSSON ANNA M ,  FISCHER KIMBA ,  GRACIAS VIJAYA J ,  ARNOLD LEE D ,  GASIECKI ALAN F

IPC: C07D409/04 ,  A61K31/416 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61P35/00 ,  A61P37/00 ,  C07D231/54 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07D495/04

Abstract: Compounds of the present invention are useful for inhibiting protein tyrosin e kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：PT1648905E

公开(公告)日：2009-04-08

申请号：PT04779180

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： DAVIDSEN STEVEN K ,  CURTIN MICHAEL L ,  MICHAELIDES MICHAEL R ,  BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4353 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/00 ,  C07D491/04 ,  C07D495/00 ,  C07D498/00 ,  C07D498/04

公开(公告)号：CA2532982C

公开(公告)日：2013-11-26

申请号：CA2532982

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula: (I), are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：SI1648905T1

公开(公告)日：2009-06-30

申请号：SI200431056

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/00 ,  A61K31/00 ,  A61P35/00 ,  C07D491/00 ,  C07D491/04 ,  C07D495/04 ,  C07D498/00

公开(公告)号：CA2532982A1

公开(公告)日：2005-02-03

申请号：CA2532982

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  HEYMAN HOWARD R ,  MUCKEY MELANIE A ,  HIRST GAVIN C ,  RAFFERTY PAUL ,  BETSCHMANN PATRICK ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  WADA CAROL K ,  FREY ROBIN R

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula: (I), are useful for inhibiting protein tyrosin e kinases. The present invention also discloses methods of making the compound s, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：DE602004018780D1

公开(公告)日：2009-02-12

申请号：DE602004018780

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW F ,  CALDERWOOD DAVID J ,  CURTIN MICHAEL L ,  DAVIDSEN STEVEN K ,  DAVIS HEATHER M ,  FREY ROBIN R ,  HEYMAN HOWARD R ,  HIRST GAVIN C ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL R ,  MUCKEY MELANIE A ,  RAFFERTY PAUL ,  WADA CAROL K

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：AT419253T

公开(公告)日：2009-01-15

申请号：AT04779180

申请日：2004-07-26

Applicant: ABBOTT LAB

Inventor： BETSCHMANN PATRICK ,  BURCHAT ANDREW ,  CALDERWOOD DAVID ,  CURTIN MICHAEL ,  DAVIDSEN STEVEN ,  DAVIS HEATHER ,  FREY ROBIN ,  HEYMAN HOWARD ,  HIRST GAVIN ,  HRNCIAR PETER ,  MICHAELIDES MICHAEL ,  MUCKEY MELANIE ,  RAFFERTY PAUL ,  WADA CAROL

IPC: C07D495/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00 ,  C07D491/04 ,  C07D498/04

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：MXPA06010904A

公开(公告)日：2007-06-11

申请号：MXPA06010904

申请日：2005-03-24

Applicant: ABBOTT LAB

Inventor： MICHAELIDES MICHAEL R ,  HOLMS JAMES H ,  STEINMAN DOUGLAS H ,  MUCKEY MELANIE A ,  WADA CAROL K ,  ARNOLD LEE D ,  DINGES JURGEN ,  DIXON RICHARD W ,  DJURIC STEVAN W ,  ERICSSON ANNA M ,  FISCHER KIMBA ,  GASIECKI ALAN F ,  GRACIAS VIJAYA J ,  RAFFERTY PAUL ,  XIA ZHIREN ,  AKRITOPOULOU-ZANZE IRINI ,  ZHANG HENRY Q ,  TAKESHITA MAKOTO

IPC: C07D409/04 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61P35/00 ,  A61P37/00 ,  C07D231/54 ,  C07D409/14 ,  C07D413/14 ,  C07D491/04 ,  C07D495/04

Abstract: Se utilizan los compuestos de la presente invencion para inhibir proteinas de tirosin-cinasas. Tambien se describen los metodos para hacer los compuestos, composiciones que los contienen y metodos de tratamiento utilizando los compuestos.