中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

38 records (took 0.022 seconds)

    DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
    7.
    发明专利
    DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 未知

    公开(公告)号：NZ588554A

    公开(公告)日：2013-03-28

    申请号：NZ58855409

    申请日：2009-04-28

    Applicant: ABBOTT LAB

    Inventor： GHAYUR TARIQ ,  MORGAN-LAPPE SUSAN E ,  REILLY EDWARD B ,  KINGSBURY GILLIAN A ,  PHILLIPS ANDREW ,  WANG JIEYI ,  BELL RANDY L ,  NORVELL SUZANNE M ,  LI YINGCHUN ,  LIU JUNJIAN ,  YING HUA

    IPC: A61K39/00

    Abstract: Disclosed is a binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; X1 is a linker with the proviso that it is not CH1; X2 is an Fc region; n is 0 or 1. Furthermore, the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site and are as defined in the specification. The disclosed binding protein is capable of binding to VEGF with an EC50 of at most about 28.25 nM, as measured by direct bind ELISA, and/or the binding protein is capable of binding to DLL4 with an EC50 of at most about 2.12nM, as measured by direct bind ELISA.

Patent Agency Ranking