公开(公告)号：CA2332229A1

公开(公告)日：1999-11-25

申请号：CA2332229

申请日：1999-05-17

Applicant: ABBOTT LAB

Inventor： BOLT RENE A ,  KANGER JOHANNES S ,  WU XIAOMAO ,  YEH SHU-JEN ,  HANNA CHARLES F ,  STALDER ARNOLD F ,  KHALIL OMAR S ,  DEMUL FRITS F M ,  LOWREY MICHAEL G

IPC: G01N21/27 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1491 ,  A61B10/00 ,  G01N21/35 ,  G01N21/47 ,  G01N21/49

Abstract: Devices and methods for non-invasively measuring at least one parameter of a sample, such as the presence or concentration of an analyte, in a body part wherein the temperature is controlled. The present invention measures light that is reflected, scattered, absorbed, or emitted by the sample from an average sampling depth, dav, that is confined within a temperature controlle d region in the tissue. This average sampling depth is preferably less than 2 mm, and more preferably less than 1 mm. Confining the sampling depth into th e tissue is achieved by appropriate selection of the separation between the source and the detector and the illumination wavelengths. In another aspect, the invention involves a method and apparatus for non-invasively measuring a t least one parameter of a body part with temperature stepping. In another aspect, the invention involves a method and apparatus for non-invasively measuring at least one parameter of a body part with temperature modulation. In another aspect, the invention provides an improved method of measuring at least one parameter of a tissue sample comprising the steps of: (a) lowering the temperature of said tissue sample to a temperature that is lower than th e normal physiological temperature of the body; and (b) determining at least o ne optical property of said tissue sample.

公开(公告)号：CA2529886C

公开(公告)日：2013-12-31

申请号：CA2529886

申请日：2004-06-15

Applicant: ABBOTT LAB

Inventor： LOWREY MICHAEL G ,  SAFAR SCOTT ,  DUNN CHADWICK M ,  GALITZ CHARLES M ,  TOTH JULIUS J ,  KUKLA RONALD E ,  HERCHENBACH STEPHEN ,  SHAIN ERIC B

IPC: B01L3/14 ,  B01L3/00 ,  B67D99/00 ,  G01N1/00 ,  G01N35/00 ,  G01N35/10

Abstract: A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.