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公开(公告)号：JP2010151849A
公开(公告)日：2010-07-08
申请号：JP2010086633
申请日：2010-04-05
Applicant: Abbott Lab , アボット・ラボラトリーズAbbott Laboratories
Inventor： LOWREY MICHAEL , SAFAR SCOTT , DUNN CHADWICK M , GALITZ CHARLES M , TOTH JULIUS J , KUKLA RONALD E , HERCHENBACH STEPHEN , SHAIN ERIC B
CPC classification number: G01N35/1004 , B01L3/50255 , B01L3/5082 , B01L99/00 , B01L2200/0668 , B01L2400/049 , B01L2400/0655 , B01L2400/0688 , G01N35/0098 , G01N35/1065 , Y10T137/0391 , Y10T137/0396 , Y10T436/25375 , Y10T436/2575
Abstract: PROBLEM TO BE SOLVED: To provide a reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. SOLUTION: A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally, horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X selected quantities of fluid from a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included. COPYRIGHT: (C)2010,JPO&INPIT
Abstract translation: 要解决的问题：为反应容器提供底部排放开口，其通过流体的表面张力支撑选定的未压缩流体的头部。 解决方案：设备处理区域包括支撑间隔开的反应容器列，与其支撑容器的排放开口连通的通道，以及用于选择性地通过排放开口排出流体的压力源。 通常，水平条形磁体被支撑用于在容器列之间选择的垂直运动。 分配头具有可选择性地定位在X选择的反应容器上的X个排出口。 计量泵机构选择性地从大量供应（其中X至少为四个）计量X个选定量的流体，并且通过排放开口选择性地将计量的所选量泵送到选定的反应容器。 还包括使用压力源从容器中抽取流体并移动磁体以形成分析物颗粒的方法。 版权所有（C）2010，JPO＆INPIT
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2.发明申请
公开(公告)号：WO0155708A3
公开(公告)日：2002-05-02
申请号：PCT/US0102895
申请日：2001-01-29
Applicant: ABBOTT LAB
Inventor： GUNDLING GERARD J , KUKLA RONALD E , SAFAR SCOTT G
IPC: G01N35/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/48 , G01N35/02 , G01N35/04 , G01N35/10
CPC classification number: G01N35/02 , B01L7/52 , G01N35/0098 , G01N35/0099 , G01N35/021 , G01N35/025 , G01N35/1065 , G01N35/109 , G01N2035/00366 , G01N2035/00524 , G01N2035/0408 , G01N2035/0443 , G01N2035/0444 , G01N2035/103
Abstract: Embodiments described herein provide methods of processing a sample containing at least one biological element. In one method, a first conductor and a second conductor are introduced into or located adjacent the sample. A voltage is applied between the first conductor and the second conductor. The voltage is adjusted to reduce an ability of the at least one biological element to be amplified or detected in a PCT reaction process, such that the biological element is removed from a binding member, and/or to unzip the at least one biological element.
Abstract translation: 本文所述的实施方案提供了处理含有至少一种生物元素的样品的方法。 在一种方法中，将第一导体和第二导体引入或位于样品附近。 在第一导体和第二导体之间施加电压。 调节电压以降低在PCT反应过程中放大或检测至少一种生物元件的能力，使得生物元件从结合构件中移出和/或解压缩至少一种生物元件。
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公开(公告)号：CA2346951C
公开(公告)日：2008-12-23
申请号：CA2346951
申请日：1999-10-12
Applicant: ABBOTT LAB
Inventor： GRAY ROBERT C , BACH MARK C , PEPE CURTIS J , DAHLKE DANIEL G , BAY DANIEL , HERCHENBACH STEVE , HALAKA FOLIM , ZUCK GARY , GALITZ CHARLES M , PIERCE MARK , SAFAR SCOTT G , CARTER MICHAEL K , TOTH JULIUS , CLEMENS JOHN M , KUKLA RONALD E
Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accesssible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container are brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.
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公开(公告)号：CA2394411A1
公开(公告)日：2001-08-02
申请号：CA2394411
申请日：2001-01-29
Applicant: ABBOTT LAB
Inventor： SAFAR SCOTT G , GUNDLING GERARD J , KUKLA RONALD E
IPC: G01N35/00 , B01L7/00 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/48 , G01N35/02 , G01N35/04 , G01N35/10
Abstract: Embodiments described herein provide methods of processing a sample containi ng at least one biological element. In one method, a first conductor and a seco nd conductor are introduced into or located adjacent the sample. A voltage is applied between the first conductor and the second conductor. The voltage is adjusted to reduce an ability of the at least one biological element to be amplified or detected in a PCT reaction process, such that the biological element is removed from a binding member, and/or to unzip the at least one biological element.
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公开(公告)号：CA2529886C
公开(公告)日：2013-12-31
申请号：CA2529886
申请日：2004-06-15
Applicant: ABBOTT LAB
Inventor： LOWREY MICHAEL G , SAFAR SCOTT , DUNN CHADWICK M , GALITZ CHARLES M , TOTH JULIUS J , KUKLA RONALD E , HERCHENBACH STEPHEN , SHAIN ERIC B
Abstract: A reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X a selected quantity of fluid a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included.
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Patent Agency Ranking
公开(公告)号：AT348660T
公开(公告)日：2007-01-15
申请号：AT99951904
申请日：1999-10-12
Applicant: ABBOTT LAB
Inventor： BACH MARK C , BAY DANIEL , CARTER MICHAEL K , CLEMENS JOHN M , DAHLKE DANIEL G , GALITZ CHARLES M , GRAY ROBERT C , HALAKA FOLIM , HERCHENBACH STEVE , KUKLA RONALD E , PEPE CURTIS J , PIERCE MARK , SAFAR SCOTT G , TOTH JULIUS , ZUCK GARY
Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accessible to the single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixed in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second process path on the single structure. Contents of the second container is brought to a first temperature different from a temperature of the first process path in the second process path. The item of interest in the second container is detected in the second process path.
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公开(公告)号：ES2468290T3
公开(公告)日：2014-06-16
申请号：ES09152512
申请日：2004-06-15
Applicant: ABBOTT LAB
Inventor： LOWREY MICHAEL , SAFAR SCOTT , DUNN CHADWICK M , GALITZ CHARLES M , TOTH JULIUS J , KUKLA RONALD E , HERCHENBACH STEPHEN , SHAIN ERIC B
Abstract: Una zona de procesado para un dispositivo de manipulación de muestras, comprendiendo dicha zona de procesado: un soporte (30) adaptado para soportar una pluralidad de recipientes de reacción (26) en una orientación generalmente vertical, en las filas generalmente paralelas primera, segunda, tercera y cuarta; donde cada fila tiene un espaciado definido desde al menos una fila adyacente, comprendiendo dichos espaciados definidos entre filas una primera ranura longitudinal generalmente vertical (48) entre la primera y la segunda fila y una segunda ranura longitudinal generalmente vertical (50) entre la tercera y la cuarta fila; dos barras magnéticas o electroimanes (64, 62) que tienen un eje longitudinal con una orientación generalmente horizontal; un medio para soportar las dos barras magnéticas o electroimanes mencionados (64, 62), estando la primera barra magnética o electroimán (64) soportado para un movimiento vertical seleccionado en la primera ranura (48), y estando la segunda barra magnética o electroimán (62) soportado para un movimiento vertical seleccionado en la segunda ranura (50).
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公开(公告)号：DE602004027284D1
公开(公告)日：2010-07-01
申请号：DE602004027284
申请日：2004-06-15
Applicant: ABBOTT LAB
Inventor： LOWREY MICHAEL , SAFAR SCOTT , DUNN CHADWICK M , GALITZ CHARLES M , TOTH JULIUS J , KUKLA RONALD E , HERCHENBACH STEPHEN , SHAIN ERIC B
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公开(公告)号：CA2346951A1
公开(公告)日：2000-04-20
申请号：CA2346951
申请日：1999-10-12
Applicant: ABBOTT LAB
Inventor： DAHLKE DANIEL G , HALAKA FOLIM , TOTH JULIUS , SAFAR SCOTT G , KUKLA RONALD E , CLEMENS JOHN M , ZUCK GARY , BACH MARK C , GALITZ CHARLES M , CARTER MICHAEL K , BAY DANIEL , PIERCE MARK , PEPE CURTIS J , GRAY ROBERT C , HERCHENBACH STEVE
Abstract: A method of performing a determination of an item of interest in a sample using a single structure is disclosed. A sample is provided accesssible to t he single structure. A first container for processing the sample is placed in a first process path on the single structure. The sample is transferred to the first container in the first process path. A reagent is added to the first container in the first process path. Contents of the first container is mixe d in the first process path. The item of interest in the sample is separated from the contents of the first container in the first process path. The separated item of interest in the sample is transferred from the first container in the first process path to a second container in a second proces s path on the single structure. Contents of the second container are brought t o a first temperature different from a temperature of the first process path i n the second process path. The item of interest in the second container is detected in the second process path.
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公开(公告)号：CA2394411C
公开(公告)日：2014-07-08
申请号：CA2394411
申请日：2001-01-29
Applicant: ABBOTT LAB
Inventor： GUNDLING GERARD J , KUKLA RONALD E , SAFAR SCOTT G
IPC: C12Q1/68 , G01N35/00 , B01L7/00 , C12M1/00 , C12N15/09 , G01N33/48 , G01N35/02 , G01N35/04 , G01N35/10
Abstract: Embodiments described herein provide methods of processing a sample containing at least one biological element. In one method, a first conductor and a second conductor are introduced into or located adjacent the sample. A voltage is applied between the first conductor and the second conductor. The voltage is adjusted to reduce an ability of the at least one biological element to be amplified or detected in a PCT reaction process, such that the biological element is removed from a binding member, and/or to unzip the at least one biological element.
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