公开(公告)号：JP2010151849A

公开(公告)日：2010-07-08

申请号：JP2010086633

申请日：2010-04-05

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： LOWREY MICHAEL ,  SAFAR SCOTT ,  DUNN CHADWICK M ,  GALITZ CHARLES M ,  TOTH JULIUS J ,  KUKLA RONALD E ,  HERCHENBACH STEPHEN ,  SHAIN ERIC B

IPC: G01N35/10 ,  B01L3/00 ,  B01L3/14 ,  B67D99/00 ,  G01N1/00 ,  G01N35/00 ,  G01N35/02

CPC classification number: G01N35/1004 ,  B01L3/50255 ,  B01L3/5082 ,  B01L99/00 ,  B01L2200/0668 ,  B01L2400/049 ,  B01L2400/0655 ,  B01L2400/0688 ,  G01N35/0098 ,  G01N35/1065 ,  Y10T137/0391 ,  Y10T137/0396 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To provide a reaction vessel with a bottom drain opening supporting a selected unpressured head of fluid by the surface tension of the fluid. SOLUTION: A device processing zone includes a support for spaced rows of reaction vessels, passages communicating with their drain openings of supported vessels, and a pressure source for selectively draining fluid through the drain openings. Generally, horizontal bar magnets are supported for selected vertical movement between the vessel rows. A dispensing head has X discharge openings selectively positionable over X selected reaction vessels. A metering pump mechanism selectively meters X selected quantities of fluid from a bulk supply (where X is at least four), and selectively pumps the metered selected quantities through the drain openings to the selected reaction vessels. Methods of drawing fluid from the vessels using the pressure source, and moving the magnets to form a pellet of analyte are also included. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：为反应容器提供底部排放开口，其通过流体的表面张力支撑选定的未压缩流体的头部。 解决方案：设备处理区域包括支撑间隔开的反应容器列，与其支撑容器的排放开口连通的通道，以及用于选择性地通过排放开口排出流体的压力源。 通常，水平条形磁体被支撑用于在容器列之间选择的垂直运动。 分配头具有可选择性地定位在X选择的反应容器上的X个排出口。 计量泵机构选择性地从大量供应（其中X至少为四个）计量X个选定量的流体，并且通过排放开口选择性地将计量的所选量泵送到选定的反应容器。 还包括使用压力源从容器中抽取流体并移动磁体以形成分析物颗粒的方法。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JPH10260189A

公开(公告)日：1998-09-29

申请号：JP25559697

申请日：1997-09-19

Applicant: ABBOTT LAB

Inventor： ARNQUIST DAVID C ,  BARNES GRADY III ,  BUTTON RICHARD D ,  DUNN CHADWICK M ,  EAST RICHARD C JR ,  FRITCHIE PATRICK P ,  GALITZ CHARLES M ,  GARDNER GREGORY E ,  GRANDONE CASS J ,  GRAY ROBERT C ,  HOLEN JAMES T ,  LUOMA ROBERT P II ,  MCCOY JIMMY D ,  MITCHELL JAMES E ,  ADRIAN J MURRY ,  MURRAY DAVID W ,  RAMSEY JACK F ,  SLESZYNSKI NEAL T ,  TOTH JULIUS J

IPC: G01N35/02 ,  G01N35/00 ,  G01N35/04

Abstract: PROBLEM TO BE SOLVED: To provide a method to produce a structure for the execution of the determination of items of concern in a sample. SOLUTION: By one method, the effective length of movement of a container 15 holding a sample at a process lane 28 which selectively and automatically performs process steps on a sample in the container 15 is determined. The process lane 28 is produced so as to correspond to at least one of predetermined throughput and predetermined physical size. Elements are arranged along the process lane 28 so that the container 15 moves the effective length during the execution of the determination of items of concern.

公开(公告)号：JPH10142232A

公开(公告)日：1998-05-29

申请号：JP25559497

申请日：1997-09-19

Applicant: ABBOTT LAB

Inventor： ARNQUIST DAVID C ,  BARNES GRADY III ,  BUTTON RICHARD D ,  DUNN CHADWICK M ,  EAST RICHARD C JR ,  FRITCHIE PATRICK P ,  GALITZ CHARLES M ,  GARDNER GREGORY E ,  GRANDONE CASS J ,  GRAY ROBERT C ,  HOLEN JAMES T ,  LUOMA ROBERT P II ,  MCCORY JIMMY D ,  MITCHELL JAMES E ,  MURRAY ADRIAN J ,  MURRAY DAVID W ,  RAMSEY JACK F ,  SLESZYNSKI NEAL T ,  TOTH JULIUS J

IPC: G01N33/543 ,  G01N35/04

Abstract: PROBLEM TO BE SOLVED: To constitute a structure for executing a process of determining concerned items in a sample by connecting a prime mover to a process path to move a container, holding the sample, along the process path. SOLUTION: A prime mover 24 is connected to a process path 10 to move a container, holding a sample, along the process path 10, that is, a plurality of teeth are provided at the outer diameter surface of a disc 16 and meshed with a gear driven by the prime mover 24 fitted to a base 14 by a bracket 26. The prime mover 24 and the whole process path 10 are driven being connected to a control device such as a computer for executing appropriate routine or the like. The disc 16 moves corresponding to the motion of the gear driven by the prime mover 24. The base 14 guides the container along the process path 10 in correspondence with the motion of the disc 16. When the disc 16 moves, the container moves from one processing station to another processing station, and concerned items in the sample are determined.

公开(公告)号：JP2009229470A

公开(公告)日：2009-10-08

申请号：JP2009160190

申请日：2009-07-06

Applicant: Abbott Lab ,  アボット・ラボラトリーズAbbott Laboratories

Inventor： SAFAR SCOTT G ,  GALITZ CHARLES M ,  HERCHENBACH STEPHEN L ,  DUNN CHADWICK M ,  MCDOWELL LARRY L

IPC: C12N15/09 ,  G01N35/02 ,  B01L3/14 ,  B01L9/06 ,  B03C1/00 ,  B03C1/02 ,  C12M1/00 ,  C12M1/26 ,  G01N35/00 ,  G01N35/10

CPC classification number: B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: PROBLEM TO BE SOLVED: To provide a structure and method for handling magnetic particles in bioassay. SOLUTION: A magnetic handling structure 1a includes a retractable magnet 4 and a probe 3 for the manipulation of magnetic particles in a biological sample, and a method is provided for handling the magnetic particles in the biological sample. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供在生物测定中处理磁性颗粒的结构和方法。 解决方案：磁性处理结构1a包括可伸缩磁体4和用于操纵生物样品中的磁性颗粒的探针3，并且提供了用于处理生物样品中的磁性颗粒的方法。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JPH11194133A

公开(公告)日：1999-07-21

申请号：JP28665298

申请日：1998-10-08

Applicant: ABBOTT LAB

Inventor： ARNQUIST DAVID C ,  BARNES GRADY III ,  BUTTON RICHARD D ,  DUNN CHADWICK M ,  EAST RICHARD C JR ,  FRITCHIE PATRICK P ,  GALITZ CHARLES M ,  GRANDONE CASS J ,  GARDNER GREGORY E ,  GRAY ROBERT C ,  HOLEN JAMES T ,  LUOMA ROBERT P II ,  MCCOY JIMMY D ,  MITCHELL JAMES E ,  MURRAY ADRIAN JOHN ,  MURRAY DAVID W ,  RAMSEY JACK F ,  SLESZYNSKI NEAL T ,  TOTH JULIUS J

IPC: G01N33/483 ,  G01N33/49 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

Abstract: PROBLEM TO BE SOLVED: To provide a method in which an interested item in a sample is decided. SOLUTION: A method provides a process route provided with a process lane 28 in which a process-step execution lane 62 used to execute a process step and a process-step prevention lane 64 used to prevent the process step are contained. A container which holds a sample is moved along the process route. The sample is introduced into the container. A reagent is introduced into the container. The sample and the reagent are mixed inside the container. The container is arranged selectively in one selected out of the process-step execution lane 62 and the process-step prevention lane 64. An interested item in the sample is decided on the basis of the reaction of the sample with the reagent.

公开(公告)号：JPH10282113A

公开(公告)日：1998-10-23

申请号：JP10300698

申请日：1998-04-14

Applicant: ABBOTT LAB

Inventor： ARNQUIST DAVID C ,  BARNES GRADY III ,  BUTTON RICHARD D ,  DUNN CHADWICK M ,  EAST RICHARD C JR ,  FRITCHIE PATRICK P ,  GALITZ CHARLES M ,  GARDNER GREGORY E ,  GRANDONE CASS J ,  GRAY ROBERT C ,  HOLEN JAMES T ,  LUOMA ROBERT P II ,  MCCOY JIMMY D ,  MITCHELL JAMES E ,  ADRIAN J MURRY ,  MURRAY DAVID W ,  RAMSEY JACK F ,  SLESZYNSKI NEAL T ,  TOTH JULIUS J

IPC: G01N33/483 ,  G01N33/49 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

Abstract: PROBLEM TO BE SOLVED: To provide a method for forming a structure for deciding an item of concern contained in a sample. SOLUTION: In a process lane 28 in which process steps are selectively and automatically performed on a sample contained in a container 15, the effective moving length of the container 15 containing the sample is decided. The lane 28 is formed so that the lane 28 may become suitable to at least either one of a predetermined throughput and a predetermined physical dimension. At the time of deciding an item of concern, elements are arranged along the lane 28 so that the container 15 may move by the effective length.

公开(公告)号：JPH10142231A

公开(公告)日：1998-05-29

申请号：JP25559297

申请日：1997-09-19

Applicant: ABBOTT LAB

Inventor： ARNQUIST DAVID C ,  BARNES GRADY III ,  BUTTON RICHARD D ,  DUNN CHADWICK M ,  EAST RICHARD C JR ,  FRITCHIE PATRICK P ,  GALITZ CHARLES M ,  GRANDONE CASS J ,  GARDNER GREGORY E ,  GRAY ROBERT C ,  HOLEN JAMES T ,  LUOMA ROBERT P II ,  MCCORY JIMMY D ,  MITCHELL JAMES E ,  MURRAY ADRIAN JOHN ,  MURRAY DAVID W ,  RAMSEY JACK F ,  SLESZYNSKI NEAL T ,  TOTH JULIUS J

IPC: G01N33/483 ,  G01N33/49 ,  G01N33/543 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

Abstract: PROBLEM TO BE SOLVED: To execute a process of determining concerned items in a sample by arranging a container selectively at either one of a process step execution lane and a process step avoiding lane. SOLUTION: A process lane 28 includes a process step execution lane 62 executing steps of a process, and a process step avoiding lane 64 avoiding the steps of the process. A container holding a sample moves along the process lane 28, and the reagent is put and mixed. The container is selectively arranged at the selected one of the process step execution lane 62 and process step avoiding lane 64, and concerned items in the sample are determined. Structure of selectively and automatically executing the steps of the process of determining the concerned items is arranged along the process lane 28 and includes bypass areas 58A, 58B, 58C.

公开(公告)号：JPH10142229A

公开(公告)日：1998-05-29

申请号：JP25559597

申请日：1997-09-19

Applicant: ABBOTT LAB

Inventor： ARNQUIST DAVID C ,  BARNES GRADY III ,  BUTTON RICHARD D ,  DUNN CHADWICK M ,  EAST RICHARD C JR ,  FRITCHIE PATRICK P ,  GALITZ CHARLES M ,  GARDNER GREGORY E ,  GRANDONE CASS J ,  GRAY ROBERT C ,  HOLEN JAMES T ,  LUOMA ROBERT P II ,  MCCORY JIMMY D ,  MITCHELL JAMES E ,  MURRAY ADRIAN J ,  MURRAY DAVID W ,  RAMSEY JACK F ,  SLESZYNSKI NEAL T ,  TOTH JULIUS J

IPC: G01N33/483 ,  G01N33/49 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04

Abstract: PROBLEM TO BE SOLVED: To determine concerned items in a sample by moving a container along a process lane, and executing a process step selectively and automatically to the sample in the container. SOLUTION: A process step is executed selectively and automatically to a sample in a container while moving the container along a process path 10 (process lane), that is, a plurality of slots 18 are arranged at a disc 16 of the process path 10, and the slots 18 move the container along the process path 10. When the container moves from a charging lane to the process lane, the container moves along the process lane by the motion of the disc 16 in order to determine concerned items in the sample. The process of determining the concerned items in the sample includes separation of solid/liquid phase, suction and cleaning of contents in the container, and the like. The process path 10 has such constitution as to be able to execute all the processes of determining the concerned items.

公开(公告)号：EP1499415A4

公开(公告)日：2009-10-28

申请号：EP03719947

申请日：2003-04-25

Applicant: ABBOTT LAB

Inventor： SAFAR SCOTT G ,  GALITZ CHARLES M ,  HERCHENBACH STEPHEN L ,  DUNN CHADWICK M ,  MCDOWELL LARRY L

IPC: C12N15/09 ,  B01L3/14 ,  B01L9/06 ,  B03C1/00 ,  B03C1/02 ,  C12M1/00 ,  C12M1/26 ,  G01N35/00 ,  B01D35/06 ,  G01N33/553 ,  G01N35/02 ,  G01N35/10

CPC classification number: B01L3/5085 ,  B01D35/06 ,  B01L3/5082 ,  B01L9/06 ,  B01L2300/0848 ,  B03C1/02 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098 ,  G01N2035/00564 ,  G01N2035/103 ,  Y10S436/809 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.

Abstract translation: 磁性处理结构（1a）包括用于操纵生物样品中的磁性颗粒的可伸缩磁体（4）和探针（3）和处理生物样品中的磁性颗粒的方法。

公开(公告)号：CA2483445C

公开(公告)日：2011-04-19

申请号：CA2483445

申请日：2003-04-25

Applicant: ABBOTT LAB

Inventor： SAFAR SCOTT G ,  GALITZ CHARLES M ,  HERCHENBACH STEPHEN L ,  DUNN CHADWICK M ,  MCDOWELL LARRY L

IPC: B01D35/06 ,  C12N15/09 ,  B01L3/14 ,  B01L9/06 ,  B03C1/00 ,  B03C1/02 ,  C12M1/00 ,  C12M1/26 ,  G01N33/553 ,  G01N35/00 ,  G01N35/02

Abstract: Magnetic handling structure (1a) comprising a retractable magnet (4) and a probe (3) for the manipulation of magnetic particles in biological samples and methods of handling magnetic particles in biological samples.