公开(公告)号：EP0574494A4

公开(公告)日：1994-07-06

申请号：EP92906944

申请日：1992-02-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  SHEPPARD GEORGE S ,  PHILLIPS JAMES G ,  PIREH DAISY ,  STEINMAN DOUGLAS H ,  MAY PAUL D ,  GUINN DENISE E ,  HEYMAN H ROBIN ,  CARRERA GEORGE M JR ,  DAVIDSEN STEVEN K

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14

CPC classification number: C07D409/14 ,  C07D417/14

公开(公告)号：AU1434292A

公开(公告)日：1992-09-15

申请号：AU1434292

申请日：1992-02-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B JR ,  CARRERA GEORGE M JR ,  DAVIDSEN STEVEN K ,  SHEPPARD GEORGE S ,  PHILLIPS JAMES G ,  PIREH DAISY ,  STEINMAN DOUGLAS H ,  MAY PAUL D ,  GUINN DENISE E ,  HEYMAN H ROBIN

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  A61K31/425

Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

公开(公告)号：AU652433B2

公开(公告)日：1994-08-25

申请号：AU1434292

申请日：1992-02-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  SHEPPARD GEORGE S ,  PHILLIPS JAMES G ,  PIREH DAISY ,  STEINMAN DOUGLAS H ,  MAY PAUL D ,  GUINN DENISE E ,  HEYMAN H ROBIN ,  CARRERA GEORGE M JR ,  DAVIDSEN STEVEN K

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14

Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

公开(公告)号：PT100314A

公开(公告)日：1993-06-30

申请号：PT10031492

申请日：1992-03-27

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  MAY PAUL D ,  GUINN DENISE E ,  STEINMAN DOUGLAS H ,  DAVIDSEN STEVEN K

IPC: C07D401/04 ,  C07D409/04 ,  C07D417/04 ,  C07D409/00 ,  A61K31/385 ,  A61K31/44

Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl] urea are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

公开(公告)号：PT94562A

公开(公告)日：1991-02-08

申请号：PT9456290

申请日：1990-06-29

Applicant: ABBOTT LAB

Inventor： CHUNG JOHN Y-L ,  GARVEY DAVID S ,  SHIOSAKI KAZUMI ,  HOLLADAY MARK W ,  NADZAN ALEX M ,  SHUE YOUE-KONG ,  BRODIE MARK S ,  TUFANO MICHAEL D ,  MAY PAUL D

IPC: C07K5/10 ,  A61K37/02

Abstract: The present invention relates to the process for preparation of a compound of formula: A-B-C-D in which A is a functionalized acetyl or R9-C(O)-, in which R9 is a heterotricyclic or a carbotricyclic; B is a functionalized 2-aminopropionyl residue; or A-B taken together are functionalized piperazinadionyl or functionalized 5-amino-3-aza-4-keto-hexanoyl; C is in which R20 is hydrogen or lower alkyl and R21 is carboxy or tetrazolyl; or B-C taken together are a bridged Ala-Asp residue or a bridged Ala-(tetrazolyl)Ala residue; and D is a functionalized ethylamine, functionalized tetra-hydro- isoquinolyl, functionalized piperazinon-1-yl, dehydro-Phe- amide or a dehydro-Phe analogue; or C-D taken together are functionalized succinimidyl, or of a pharmaceutically acceptable salt thereof, characterized by comprising: a) the step-by-step coupling of the adequately protected amino acids or of amino acid analogues represented by A, A-B, B, C, C-D or D, as here defined, followed by removal of the protecting groups; or b) coupling of the adequately protected fragments of dipeptide or greater length, comprising said fragments, the amino acids or amino acid analogues, represented by the formulae A, A-B, B, C, C-D and D, as here defined, followed by removal of the protecting groups. The invention also relates to the process for preparation of pharmaceutical compositions containing those compounds, which are useful in the treatment of disorders of the central nervous system, in substance abuse, in gastrointestinal disorders, endocrine disorders and nutritional disorders, and in the treatment of shock and of respiratory and cardiovascular insufficiencies.

公开(公告)号：IE920365A1

公开(公告)日：1992-08-26

申请号：IE920365

申请日：1992-02-04

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  SHEPPARD GEORGE S ,  PHILLIPS JAMES G ,  PIREH DAISY ,  STEINMAN DOUGLAS H ,  MAY PAUL D ,  GUINN DENISE E ,  HEYMAN H ROBIN ,  JR GEORGE M CARRERA ,  DAVIDSEN STEVEN K

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D409/00 ,  C07D417/00

Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.

公开(公告)号：CA2100682A1

公开(公告)日：1992-08-21

申请号：CA2100682

申请日：1992-02-14

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  SHEPPARD GEORGE S ,  PHILLIPS JAMES G ,  PIREH DAISY ,  STEINMAN DOUGLAS H ,  MAY PAUL D ,  GUINN DENISE E ,  HEYMAN H ROBIN ,  CARRERA GEORGE M JR ,  DAVIDSEN STEVEN K

IPC: A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D417/14 ,  C07D413/14

Abstract: 2100682 9214732 PCTABS00015 Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

公开(公告)号：IE920715A1

公开(公告)日：1992-10-07

申请号：IE920715

申请日：1992-03-05

Applicant: ABBOTT LAB

Inventor： SUMMERS JAMES B ,  STEINMAN DOUGLAS H ,  GUINN DENISE E ,  DAVIDSEN STEVEN K ,  MAY PAUL D

IPC: C07D401/04 ,  C07D409/04 ,  C07D417/04 ,  C07D401/00 ,  C07D409/00 ,  C07D417/00

Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl] urea are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.