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公开(公告)号：DE69613347T2
公开(公告)日：2002-04-18
申请号：DE69613347
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： MEYER D , ALTENBACH J , BASHA Z , CARROLL A , DRIZIN IRENE , KERWIN F , LEBOLD A , LEE L , PRATT K , SIPPY B , TIETJE R , YAMAMOTO M
IPC: A61K31/505 , A61K31/519 , A61P13/02 , A61P15/00 , A61P25/02 , C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D491/056 , C07D495/04 , C07D498/04 , C07D487/02 , C07D495/02 , C07D487/00
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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公开(公告)号：DE60122496D1
公开(公告)日：2006-10-05
申请号：DE60122496
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： CARROLL A , AGRIOS KONSTANTINOS A , ALTENBACH J , DRIZIN IRENE , KORT J
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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公开(公告)号：DE60103615T2
公开(公告)日：2005-06-09
申请号：DE60103615
申请日：2001-03-02
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , ALTENBACH J , CARROLL A
IPC: C07D491/147 , A61K31/437 , A61P1/00 , A61P7/12 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/08 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P43/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/04 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14 , A61K31/4353 , A61P13/00 , C07D491/04
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公开(公告)号：DE69613347D1
公开(公告)日：2001-07-19
申请号：DE69613347
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： MEYER D , ALTENBACH J , BASHA Z , CARROLL A , DRIZIN IRENE , KERWIN F , LEBOLD A , LEE L , PRATT K , SIPPY B , TIETJE R , YAMAMOTO M
IPC: A61K31/505 , A61K31/519 , A61P13/02 , A61P15/00 , A61P25/02 , C07D401/06 , C07D403/06 , C07D471/04 , C07D473/04 , C07D475/02 , C07D487/04 , C07D491/04 , C07D491/056 , C07D495/04 , C07D498/04 , C07D487/02 , C07D495/02 , C07D487/00
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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公开(公告)号：DE60122496T2
公开(公告)日：2007-05-24
申请号：DE60122496
申请日：2001-05-03
Applicant: ABBOTT LAB
Inventor： CARROLL A , AGRIOS KONSTANTINOS A , ALTENBACH J , DRIZIN IRENE , KORT J
IPC: C07D335/02 , C07D471/14 , A61K20060101 , A61K31/436 , A61K31/4365 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4741 , A61K31/4743 , A61K31/4745 , A61K31/55 , A61P20060101 , A61P1/00 , A61P9/12 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/02 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P29/02 , C07C45/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D20060101 , C07D211/86 , C07D219/00 , C07D309/30 , C07D309/32 , C07D471/04 , C07D491/00 , C07D491/04 , C07D491/052 , C07D491/14 , C07D491/147 , C07D491/153 , C07D495/04 , C07D495/14 , C07D513/00
Abstract: The present invention provides novel compounds of formula I which may be useful in hyperpolarizing cell membranes, opening potassium channels, relaxing smooth muscle cells, and inhibiting bladder contractions.
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Patent Agency Ranking
公开(公告)号：DE60103615D1
公开(公告)日：2004-07-08
申请号：DE60103615
申请日：2001-03-02
Applicant: ABBOTT LAB
Inventor： DRIZIN IRENE , ALTENBACH J , CARROLL A
IPC: C07D491/147 , A61K31/437 , A61P1/00 , A61P7/12 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/08 , A61P13/10 , A61P15/00 , A61P15/06 , A61P15/08 , A61P15/10 , A61P17/14 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/28 , A61P43/00 , C07C45/29 , C07C45/41 , C07C45/63 , C07C205/44 , C07D471/04 , C07D491/14 , C07D495/14 , C07D498/04 , C07D498/14 , A61K31/4353 , A61P13/00 , C07D491/04
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公开(公告)号：DE69609051D1
公开(公告)日：2000-08-03
申请号：DE69609051
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： MEYER D , ALTENBACH J , BASHA Z , CARROLL A , DRIZIN IRENE , KERWIN F , LEBOLD A , LEE L , ELMORE W , SIPPY B , TIETJE R , WENDT D , YAMAMOTO M
IPC: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , C07D487/16 , A61K31/395
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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公开(公告)号：DE69707497T2
公开(公告)日：2002-07-11
申请号：DE69707497
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER D , ALTENBACH J , BASHA FATIMA , CARROLL A , DRIZIN IRENE , KERWIN F , WENDT D , HAIGHT R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：DE69707497D1
公开(公告)日：2001-11-22
申请号：DE69707497
申请日：1997-12-04
Applicant: ABBOTT LAB
Inventor： MEYER D , ALTENBACH J , BASHA FATIMA , CARROLL A , DRIZIN IRENE , KERWIN F , WENDT D , HAIGHT R , ZHANG WEIJIANG
IPC: A61K31/517 , A61K31/519 , A61P13/08 , A61P13/10 , A61P15/04 , A61P43/00 , C07D207/26 , C07D311/58 , C07D491/04 , C07D491/052 , C07D495/04 , C07D519/00 , A61K31/415
Abstract: The present invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 adrenoreceptors and treating BPH.
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公开(公告)号：DE69609051T2
公开(公告)日：2001-03-22
申请号：DE69609051
申请日：1996-01-11
Applicant: ABBOTT LAB
Inventor： MEYER D , ALTENBACH J , BASHA Z , CARROLL A , DRIZIN IRENE , KERWIN F , LEBOLD A , LEE L , ELMORE W , SIPPY B , TIETJE R , WENDT D , YAMAMOTO M
IPC: A61K31/437 , A61K31/519 , A61P13/00 , A61P13/08 , A61P43/00 , C07D403/06 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/04 , C07D491/048 , C07D491/14 , C07D491/147 , C07D495/04 , C07D495/14 , C07D487/16 , A61K31/395
Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.
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