公开(公告)号：DE69613347D1

公开(公告)日：2001-07-19

申请号：DE69613347

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA Z ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  LEBOLD A ,  LEE L ,  PRATT K ,  SIPPY B ,  TIETJE R ,  YAMAMOTO M

IPC: A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  C07D487/02 ,  C07D495/02 ,  C07D487/00

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：DE69609051D1

公开(公告)日：2000-08-03

申请号：DE69609051

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA Z ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  LEBOLD A ,  LEE L ,  ELMORE W ,  SIPPY B ,  TIETJE R ,  WENDT D ,  YAMAMOTO M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：DE69613347T2

公开(公告)日：2002-04-18

申请号：DE69613347

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA Z ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  LEBOLD A ,  LEE L ,  PRATT K ,  SIPPY B ,  TIETJE R ,  YAMAMOTO M

IPC: A61K31/505 ,  A61K31/519 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D473/04 ,  C07D475/02 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D495/04 ,  C07D498/04 ,  C07D487/02 ,  C07D495/02 ,  C07D487/00

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a bicyclic heterocyclic ring system. The compounds are alpha -1 adrenergic antagonists and are useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.

公开(公告)号：DE69609051T2

公开(公告)日：2001-03-22

申请号：DE69609051

申请日：1996-01-11

Applicant: ABBOTT LAB

Inventor： MEYER D ,  ALTENBACH J ,  BASHA Z ,  CARROLL A ,  DRIZIN IRENE ,  KERWIN F ,  LEBOLD A ,  LEE L ,  ELMORE W ,  SIPPY B ,  TIETJE R ,  WENDT D ,  YAMAMOTO M

IPC: A61K31/437 ,  A61K31/519 ,  A61P13/00 ,  A61P13/08 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D491/04 ,  C07D491/048 ,  C07D491/14 ,  C07D491/147 ,  C07D495/04 ,  C07D495/14 ,  C07D487/16 ,  A61K31/395

Abstract: The present invention relates to a compound of the formula and the pharmaceutically acceptable salts thereof wherein W is a tricyclic heterocyclic ring system; which is an alpha -1 adrenergic antagonist and is useful in the treatment of BPH; also disclosed are alpha -1 antagonist compositions and a method for antagonizing alpha -1 receptors and treating BPH.