公开(公告)号：WO2004032908A9

公开(公告)日：2004-05-27

申请号：PCT/US0331220

申请日：2003-10-02

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  DINGES JUERGEN ,  SAUER DARYL R ,  HENKIN JACK

IPC: A61K31/455 ,  C07D213/82 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  A61K31/00

CPC classification number: C07D213/82 ,  A61K31/455 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04

Abstract: Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.

Abstract translation: 具有下式的化合物是血管生成抑制剂。 还公开了含有该化合物的组合物，制备该化合物的方法以及使用该化合物的治疗方法。

公开(公告)号：WO2007149907A3

公开(公告)日：2008-02-07

申请号：PCT/US2007071649

申请日：2007-06-20

Applicant: ABBOTT LAB ,  PENNING THOMAS D ,  THOMAS SHEELA A ,  HAJDUK PHILIP J ,  SAUER DARYL R ,  SARRIS KATHY ,  GIRANDA VINCENT L

Inventor： PENNING THOMAS D ,  THOMAS SHEELA A ,  HAJDUK PHILIP J ,  SAUER DARYL R ,  SARRIS KATHY ,  GIRANDA VINCENT L

IPC: C07D487/04 ,  A61K31/519

CPC classification number: C07D487/04

Abstract: The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.

Abstract translation: 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。

公开(公告)号：WO2004032908A3

公开(公告)日：2004-08-12

申请号：PCT/US0331220

申请日：2003-10-02

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  DINGES JUERGEN ,  SAUER DARYL R ,  HENKIN JACK

IPC: A61K31/455 ,  C07D213/82 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04

CPC classification number: C07D213/82 ,  A61K31/455 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04

Abstract: Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.

Abstract translation: 具有下式的化合物是血管发生抑制剂。 还公开了含有化合物的组合物，制备化合物的方法和使用该化合物的治疗方法。

公开(公告)号：WO9950275A3

公开(公告)日：2001-02-22

申请号：PCT/US9904658

申请日：1999-03-11

Applicant: ABBOTT LAB

Inventor： SAUER DARYL R ,  HAVIV FORTUNA ,  RANDOLPH JOHN ,  MORT NICHOLAS A ,  DALTON CHRISTOPHER R ,  BRUNCKO MILAN ,  KAMINSKI MICHELE A ,  CRAWFORD BRADLEY W ,  FREY LISA MARIE ,  GREER JONATHON

IPC: A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61P5/24 ,  A61P13/08 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07H17/08 ,  A61K31/70

CPC classification number: C07H17/08

Abstract: Disclosed are 3'-N-desmethyl-3'-N-susbstituted-6-O-methyl-11-deoxy-11, 12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.

Abstract translation: 公开了作为促黄体激素释放激素（LHRH）的拮抗剂的3'-N-去甲基-3'-N-疑似取代的-6-O-甲基-11-脱氧-11,12-环状氨基甲酸酯红霉素A衍生物。 还公开了包含该化合物的药物组合物，使用该化合物的方法及其制备方法。

公开(公告)号：EP0683792A4

公开(公告)日：1998-11-18

申请号：EP94905391

申请日：1993-12-14

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  GREER JONATHAN ,  SWENSON ROLF E ,  SAUER DARYL R

IPC: A61K38/04 ,  A61K38/00 ,  A61P15/00 ,  C07K7/06 ,  C07K7/23 ,  C07K7/00 ,  A61K38/08 ,  A61K38/24 ,  C07K14/00

CPC classification number: C07K7/23 ,  A61K38/00

公开(公告)号：ZA200908017B

公开(公告)日：2015-08-26

申请号：ZA200908017

申请日：2009-11-13

Applicant: ABBOTT LAB ,  ABBOTT GMBH & CO KG

Inventor： AMBERG WILHELM ,  BRAJE WILFRED ,  MEZLER MARIO ,  BAKKER MARGARETHA HENRICA MARIA ,  SAUER DARYL R ,  GENESTE HERVE

公开(公告)号：AU2003223548A1

公开(公告)日：2003-10-27

申请号：AU2003223548

申请日：2003-04-03

Applicant: ABBOTT LAB

Inventor： SAUER DARYL R ,  KOLACZKOWSKI LAWRENCE ,  VASUDEVAN ANIL ,  PARK DAVID C ,  HAVIV FORTUNA ,  BRADLEY MICHAEL F ,  HENKIN JACK ,  DINGES JURGEN

IPC: C07D241/24 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/455 ,  A61K31/4747 ,  A61K31/496 ,  A61K31/497 ,  A61K31/506 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/551 ,  A61P1/00 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P15/00 ,  A61P17/00 ,  A61P27/02 ,  A61P35/00 ,  C07D213/81 ,  C07D213/82 ,  C07D239/28 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D491/10 ,  C07D491/113

Abstract: Compounds having the formula are angiogenesis inhibitors. Also disclosed are compositions containing the compounds, methods of making the compounds, and methods of treatment using the compounds.

公开(公告)号：ES2164096T3

公开(公告)日：2002-02-16

申请号：ES94905391

申请日：1993-12-14

Applicant: ABBOTT LAB

Inventor： HAVIV FORTUNA ,  GREER JONATHAN ,  SWENSON ROLF E ,  SAUER DARYL R

IPC: A61K38/00 ,  A61P15/00 ,  C07K7/06 ,  C07K7/23 ,  A61K38/04 ,  A61K38/09 ,  A61K38/24

Abstract: A class of potent LHRH decapeptide antagonists possess N-alkylated aminoacyl residues where the side-chain portion of the residue is a 4-(substimtedamino)phenylalanyl, 4-(substituted-amino)cyclohexylalanyl, or OMEGA -(substitutedamino)alkyl group, and additionally the aminoacyl residues at position 5 are N-alkylated on the nitrogen atom of the peptide backbone.

公开(公告)号：BG104844A

公开(公告)日：2001-07-31

申请号：BG10484400

申请日：2000-10-11

Applicant: ABBOTT LAB

Inventor： SAUER DARYL R ,  HAVIV FORTUNA ,  RANDOLPH JOHN ,  MORT NICHOLAS A ,  DALTON CHRISTOPHER R ,  BRUNCKO MILAN ,  KAMINSKI MICHELE A ,  CRAWFORD BRADLEY W ,  FREY LISA M ,  GREER JONATHON

IPC: A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61P5/24 ,  A61P13/08 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07H17/08 ,  C07H1/00

Abstract: Disclosed are 3'-N-desmethyl-3'-N-substituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same. 15 claims

公开(公告)号：SK13972000A3

公开(公告)日：2001-07-10

申请号：SK13972000

申请日：1999-03-11

Applicant: ABBOTT LAB

Inventor： SAUER DARYL R ,  HAVIV FORTUNA ,  RANDOLPH JOHN ,  MORT NICHOLAS A ,  DALTON CHRISTOPHER R ,  BRUNCKO MILAN ,  KAMINSKI MICHELE A ,  CRAWFORD BRADLEY W ,  FREY LISA MARIE ,  GREER JONATHAN

IPC: A61K31/7042 ,  A61K31/7048 ,  A61K31/7056 ,  A61P5/24 ,  A61P13/08 ,  A61P15/00 ,  A61P35/00 ,  A61P43/00 ,  C07H17/08 ,  A61K31/70 ,  C07H1/00

Abstract: Disclosed are 3'-N-desmethyl-3'-N-substituted-6-O-methyl-11-deoxy-11,12-cyclic carbamate erythromycin A derivatives which are antagonists of lutenizing hormone-releasing hormone (LHRH). Also disclosed are pharmaceutical compositions comprising the compounds, to methods of using the compounds and to the process of making the same.