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公开(公告)号：WO0166534A3
公开(公告)日：2003-10-16
申请号：PCT/US0106885
申请日：2001-03-05
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , BLACK LAWRENCE A , DWIGHT WESLEY J , FAGHIH RAMIN , GENTLES ROBERT G , LIU HUAQING , PHELAN KATHLEEN M , VASUDEVAN ANIL , ZHANG HENRY Q
IPC: A61P37/08 , C07D205/04 , C07D205/08 , C07D207/08 , C07D207/16 , C07D213/56 , C07D233/54 , C07D239/10 , C07D243/08 , C07D271/06 , C07D277/30 , C07D295/205 , C07D307/68 , C07D333/24 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D487/08 , A61K31/495
CPC classification number: C07D207/08 , C07D205/04 , C07D205/08 , C07D207/16 , C07D213/56 , C07D233/64 , C07D239/10 , C07D243/08 , C07D271/06 , C07D277/30 , C07D295/205 , C07D307/68 , C07D333/24 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D487/08
Abstract: Compounds of formula (I), compounds of formula (II), compounds of formula (III), and compounds of formula (IV), or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Processes to make the compounds and methods of treatment using the compounds are also disclosed.
Abstract translation: 式（I）化合物，式（II）化合物，式（III）化合物和式（IV）化合物或其药学上可接受的盐可用作H3受体拮抗剂。 还公开了制备化合物的方法和使用该化合物的处理方法。
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公开(公告)号：MXPA02012851A
公开(公告)日：2003-09-05
申请号：MXPA02012851
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： DWIGHT WESLEY J
IPC: C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
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公开(公告)号：AU7338401A
公开(公告)日：2002-01-30
申请号：AU7338401
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , FAGHIH RAMIN , DWIGHT WESLEY J , VASUDEVAN ANIL , CONNER SCOTT E
IPC: C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
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公开(公告)号：CA2415396A1
公开(公告)日：2002-01-24
申请号：CA2415396
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： DWIGHT WESLEY J , BENNANI YOUSSEF L , FAGHIH RAMIN , CONNER SCOTT E , VASUDEVAN ANIL
IPC: C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
Abstract: Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclose d are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
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公开(公告)号：BR0108088A
公开(公告)日：2004-04-06
申请号：BR0108088
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , FAGHIH RAMIN , DWIGHT WESLEY J , VASUDEVAN ANIL , CONNER SCOTT E
IPC: C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
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Patent Agency Ranking
公开(公告)号：PE20020191A1
公开(公告)日：2002-03-12
申请号：PE2001000701
申请日：2001-07-12
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , FAGHIG RAMIN , VASUEDVAN ANIL , DWIGHT WESLEY J , CONNER SCOTT E
IPC: C07D295/08 , A61K20060101 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14 , A61K
Abstract: SE REFIERE A PIRROLIDINAS 1,3-DISUSTITUIDAS Y 1,3,3-TRISUSTITUIDAS DE FORMULA I DONDE Z ES UN ENLACE, CH2; R1 ES OR2, NR3R4; GRUPO a; R2 ES H, ALCOXICARBONILO, ALQUILO, ALQUILCARBONILO, ENTRE OTROS; R3 Y R4 SON H, ALQUENILO, ALQUENILCARBONILO, ALQUILSULFONILO, ENTRE OTROS; R5, R6, R7 Y R9 SON H, ALQUILO; R7 Y R1 JUNTOS SON =O; R8 ES ALQUILCARBONILO, ARILO, ARILCARBONILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 1-{3-[(4'-CIANO[1,1'-BIFENIL]-4-IL)OXI]PROPIL}-3-PIRROLIDINILCARBAMATO DE TERBUTILO; N,N-DIMETIL-N-[(3S)-1-(3-{[4'-(1-PIRROLIDINILCARBONIL)[1,1'-BIFENIL]-4-IL]OXI}PROPIL)PIRROLIDINIL]AMINA, ENTRE OTROS; EL COMPUESTO I ES UN MODULADOR DEL RECEPTOR DE HISTAMINA-3 Y PUEDE SER UTIL PARA EL TRATAMIENTO DE INFARTO AGUDO DE MIOCARDIO, ASMA, CARCINOMA CUTANEO, DEPRESION, INFLAMACION, ENFERMEDAD DE ALZHEIMER, EPILEPSIA. NARCOLEPSIA
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公开(公告)号：PE01912002A1
公开(公告)日：2002-03-12
申请号：PE0007012001
申请日：2001-07-12
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , FAGHIG RAMIN , VASUEDVAN ANIL , DWIGHT WESLEY J , CONNER SCOTT E
IPC: C07D295/08 , A61K20060101 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14 , A61K
CPC classification number: C07D401/12 , C07D207/12 , C07D207/14 , C07D207/16 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
Abstract: SE REFIERE A PIRROLIDINAS 1,3-DISUSTITUIDAS Y 1,3,3-TRISUSTITUIDAS DE FORMULA I DONDE Z ES UN ENLACE, CH2; R1 ES OR2, NR3R4; GRUPO a; R2 ES H, ALCOXICARBONILO, ALQUILO, ALQUILCARBONILO, ENTRE OTROS; R3 Y R4 SON H, ALQUENILO, ALQUENILCARBONILO, ALQUILSULFONILO, ENTRE OTROS; R5, R6, R7 Y R9 SON H, ALQUILO; R7 Y R1 JUNTOS SON =O; R8 ES ALQUILCARBONILO, ARILO, ARILCARBONILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 1-{3-[(4'-CIANO[1,1'-BIFENIL]-4-IL)OXI]PROPIL}-3-PIRROLIDINILCARBAMATO DE TERBUTILO; N,N-DIMETIL-N-[(3S)-1-(3-{[4'-(1-PIRROLIDINILCARBONIL)[1,1'-BIFENIL]-4-IL]OXI}PROPIL)PIRROLIDINIL]AMINA, ENTRE OTROS; EL COMPUESTO I ES UN MODULADOR DEL RECEPTOR DE HISTAMINA-3 Y PUEDE SER UTIL PARA EL TRATAMIENTO DE INFARTO AGUDO DE MIOCARDIO, ASMA, CARCINOMA CUTANEO, DEPRESION, INFLAMACION, ENFERMEDAD DE ALZHEIMER, EPILEPSIA. NARCOLEPSIA
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公开(公告)号：CA2351187A1
公开(公告)日：2000-05-25
申请号：CA2351187
申请日：1999-11-09
Applicant: ABBOTT LAB
Inventor： CRAWFORD BRADLEY W , HAVIV FORTUNA , SWENSON ROLF E , BRUNCKO MILAN , KAMINSKI MICHELE A , DWIGHT WESLEY J , FREY LISA M , DEMATTEI JOHN , GREER JONATHAN
IPC: C07D217/06 , A61K31/472 , A61K31/4725 , A61K31/4741 , A61K31/55 , A61P5/00 , A61P13/08 , A61P15/00 , A61P35/00 , C07D217/04 , C07D217/14 , C07D217/16 , C07D217/18 , C07D217/20 , C07D217/22 , C07D217/26 , C07D223/16 , C07D401/04 , C07D401/06 , C07D401/08 , C07D401/12 , C07D491/04 , C07D491/056 , C07D221/00 , C07D317/00 , C07D319/00 , C07D401/10
Abstract: Tetrahydroisoquinoline derivatives of formula (I): or a pharmaceutically acceptable salt, ester, or prodrug thereof, having activity as an LHRH antagonist, as well as pharmaceutical compositions containing the same, and methods for their use and preparation.
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公开(公告)号：CA2415396C
公开(公告)日：2011-03-08
申请号：CA2415396
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , FAGHIH RAMIN , DWIGHT WESLEY J , VASUDEVAN ANIL , CONNER SCOTT E
IPC: C07D207/12 , C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
Abstract: Compounds of formula (I) are useful in treating diseases or conditions prevented by or ameliorated with histamine-3 receptor ligands. Also disclosed are histamine-3 receptor ligand compositions and methods of antagonizing or agonizing histamine-3 receptors.
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公开(公告)号：DE60130460T2
公开(公告)日：2008-06-05
申请号：DE60130460
申请日：2001-07-11
Applicant: ABBOTT LAB
Inventor： BENNANI YOUSSEF L , FAGHIH RAMIN , DWIGHT WESLEY J , VASUDEVAN ANIL , CONNER SCOTT E
IPC: C07D207/12 , C07D295/08 , A61K31/40 , A61K31/4025 , A61K31/4178 , A61K31/427 , A61K31/443 , A61K31/4439 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P35/00 , A61P43/00 , C07D207/06 , C07D207/14 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12 , C07D417/14
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