公开(公告)号：AU498925B2

公开(公告)日：1979-03-29

申请号：AU1655776

申请日：1976-08-04

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14 ,  A61K31/495 ,  C07D5/06

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：SE7412163L

公开(公告)日：1975-03-27

申请号：SE7412163

申请日：1974-09-26

Applicant: ABBOTT LAB

Inventor： DUNNIGAN D A ,  GEISZLER A O ,  HOLLAND J B

IPC: C07C217/74 ,  A61K31/13 ,  A61K31/135 ,  C07C67/00 ,  C07C213/00 ,  C07C93/24

Abstract: Covers a compound selected from the group consisting of a member of the formula: wherein R1 is a radial selected from the group consisting of higher branched or straight chain alkyl and cycloalkyl radicals wherein said R1 radical contains at least six carbon atoms, R2 is a radical selected from the group consisting of hydrogen, loweralkyl and loweralkanol radicals, wherein said R2 radical contains 1 - 3 carbon atoms, and R3 is methoxy; and nontoxic pharmaceutically acceptable acid addition salts thereof. Also covers the use of said compound as a local anesthetic and pharmaceutical compositions comprising said above compounds as the active ingredient.

公开(公告)号：SE422685B

公开(公告)日：1982-03-22

申请号：SE7611379

申请日：1976-10-13

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：AU502420B2

公开(公告)日：1979-07-26

申请号：AU1759176

申请日：1976-09-09

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/14 ,  A61K31/495 ,  A61K31/505 ,  A61K31/55 ,  A61P9/12 ,  C07D239/84 ,  C07D239/95 ,  C07D243/00 ,  C07D243/08 ,  C07D307/14 ,  C07D405/06 ,  C07D407/14

Abstract: Described are the compounds 2[4(tetrahydro-2-furoyl)-hexahydro-1,4-diazepinyl-1]-4-amino-6,7-dimet hoxy quinazoline and pharmaceutically acceptable acid addition salts thereof. The compounds are useful as antihypertensive agents.

公开(公告)号：SE7812825L

公开(公告)日：1979-06-22

申请号：SE7812825

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： DUNNIGAN D A ,  MARTIN J R ,  TADANIER J S ,  FREIBERG L A

IPC: C07H15/224 ,  C07H15/22

公开(公告)号：SE431208B

公开(公告)日：1984-01-23

申请号：SE8008533

申请日：1980-12-04

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.

公开(公告)号：SE7812825A

公开(公告)日：1979-06-22

申请号：SE7812825

申请日：1978-12-13

Applicant: ABBOTT LAB

Inventor： DUNNIGAN D A ,  MARTIN J R ,  TADANIER J S ,  FREIBERG L A

IPC: C07H15/224 ,  C07H15/22

CPC classification number: C07H15/224

公开(公告)号：SE7611379L

公开(公告)日：1977-04-15

申请号：SE7611379

申请日：1976-10-13

Applicant: ABBOTT LAB

Inventor： WINN M ,  KYNCL J ,  DUNNIGAN D A ,  JONES P H

IPC: C07D405/12 ,  A61K31/505 ,  A61P9/12 ,  A61P25/04 ,  C07D309/08 ,  C07D405/14

Abstract: Described are antihypertensive agents selected from the class consisting of 2[4(tetrahydro-2-furoyl)-piperazino]-4-amino-6,7-dimethoxyquinazoline and 2-[4(tetrahydropyran-2-carbonyl)-piperazinyl]-4-amino-6,7-dimethoxyqui nazoline, and pharmaceutically acceptable acid addition salts thereof. The compounds are highly water soluble and can be administered in time release form as well as parenterally, including intravenously.