公开(公告)号：WO03090679A2

公开(公告)日：2003-11-06

申请号：PCT/US0312590

申请日：2003-04-24

Applicant: ABBOTT LAB

Inventor： CLARK RICHARD ,  DJURIC STEVAN ,  MA ZHENKUN ,  WANG SANYI

IPC: C07H17/00 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/08 ,  A61K

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 具有式（I）和式（II）的抗菌化合物及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含有该化合物的组合物，以及预防或治疗细菌感染的方法 公开了使用该化合物。

公开(公告)号：AT398627T

公开(公告)日：2008-07-15

申请号：AT00930370

申请日：2000-05-04

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  OR YAT ,  PHAN LY ,  ZHANG SUOMING ,  CLARK RICHARD

IPC: C07H17/08 ,  A61K31/70 ,  A61K31/7048 ,  A61P31/04

Abstract: A compound having the formula selected from the group consisting ofa compound of formula Ia compound of formula IIa compound of formula IIIas well as and pharmaceutically acceptable salts, esters, solvates, metabolites, and prodrugs thereof, are useful in treating bacterial infections. Also provided are pharmaceutically acceptible compositions, methods of treating bacterial infections, and processes for the preparation of the compounds.

公开(公告)号：CA2518443A1

公开(公告)日：2004-09-30

申请号：CA2518443

申请日：2003-03-12

Applicant: ABBOTT LAB

Inventor： HANSEN TODD MATTHEW ,  TUFANO MICHAEL ,  CLARK RICHARD ,  WAGNER ROLF ,  HINMAN MIRA ,  LARSON DANIEL P ,  WEITZBERG MOSHE ,  KALVIN DOUGLAS ,  SANDERS WILLIAM ,  BOSSE TODD D ,  ROSENBERG TERESA ,  DANDLIKER PETER ,  MOTTER CHRISTOPHER ,  MA ZHENKUN ,  ANDERSON DAVID ,  PALAZZO FABIO ,  DAVID CAROLINE ,  COOPER CURT ,  BEUTEL BRUCE ,  GU YU-GUI ,  REHM TAMARA ,  LYNCH LINDA ,  YONG HONG ,  ZHANG TIANYUAN

IPC: A61P31/04 ,  C07D471/04 ,  A61K31/435

Abstract: Antibacterials having formula (I), and salts, prodrugs, and salts of prodrug s thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：CA2483281A1

公开(公告)日：2003-11-06

申请号：CA2483281

申请日：2003-04-24

Applicant: ABBOTT LAB

Inventor： WANG SANYI ,  MA ZHENKUN ,  DJURIC STEVAN ,  CLARK RICHARD

IPC: C07H17/00 ,  A61K31/7052 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: Antibacterial compounds having formula (I) and formula (II), and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

公开(公告)号：BG64707B1

公开(公告)日：2005-12-30

申请号：BG10443400

申请日：2000-05-15

Applicant: ABBOTT LAB

Inventor： PHAN LY ,  OR YAT SUN ,  CHU DANIEL ,  PLATTNER JACOB ,  CHEN YAN ,  CLARK RICHARD

IPC: A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  A61K31/70

Abstract: The invention relates to novel 2-halo-6-O-substituted ketolide derivatives with the formula to their pharmaceutically acceptable salts having antibacterial activity, to pharmaceutical compositions comprising a therapeutically effective amount of a compound according to the invention in combination with a pharmaceutically acceptable carrier, as well as to the utilization of the compounds or their pharmaceutically acceptable salt for the preparation of a medicament for treating bacterial infections in mammals. The invention also relates to the preparation of the compounds.

公开(公告)号：CA2476223A1

公开(公告)日：2003-08-21

申请号：CA2476223

申请日：2003-02-11

Applicant: ABBOTT LAB

Inventor： MA ZHENKUN ,  CLARK RICHARD ,  WANG SANYI ,  DJURIC STEVAN

IPC: A61K31/7056 ,  A61P31/04 ,  A61P43/00 ,  C07H17/08 ,  A61K31/7048

Abstract: Antibacterial compounds having formula (I), and salts, prodrugs, and salts o f prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.