公开(公告)号：RU2153504C2

公开(公告)日：2000-07-27

申请号：RU96123123

申请日：1995-04-26

Applicant: BASF AG

Inventor： VIL GEL M AMBERG ,  KHARAL D BERNARD ,  EHRNST BUSHMANN ,  ANDREAS KHAUPT ,  LOTAR JANICHKE ,  BERND JANSSEN ,  UL RIKH KARL ,  ANDREAS KLING ,  SHTEFAN MJULLER ,  BERND DEH POTTSOLLI ,  KURT RITTER ,  MARKO TIES ,  TOMAS TSIRKE

IPC: A61K38/08 ,  A61P35/00 ,  C07K1/08 ,  C07K5/10 ,  C07K5/103 ,  A61K38/00 ,  C07K7/06 ,  C07K14/52

Abstract: medicine. SUBSTANCE: described is pentapeptide hydrochloride of formula I: Me2Val-Val-MeVai-Pro-Pro-NHBzl.HCl (I) wherein Me is methyl and Bzl is benzyl. Compound has antitumor activity. Also described are methods of preparation thereof. EFFECT: improved properties of the title compound. 6 cl, 2 ex

公开(公告)号：RU2175328C2

公开(公告)日：2001-10-27

申请号：RU99104925

申请日：1997-07-29

Applicant: BASF AG

Inventor： DORIT BAUKE ,  UDO LANGE ,  KHEL MUT MAK ,  VERNER ZAJTS ,  TOMAS TSIRKE ,  KHANS VOL FGANG KHEFFKEN ,  VIL FRID KHORNBERGER

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065

公开(公告)号：RU2014317C1

公开(公告)日：1994-06-15

申请号：SU4830460

申请日：1990-07-17

Applicant: BASF AG

Inventor： RAJNER KOBER ,  RAJNER SEELE ,  KHAJNTS ISAK ,  EKKARD KHIKMANN ,  NORBERT GETTS ,  TOMAS TSIRKE

IPC: C07C17/35 ,  C07C17/357 ,  C07C25/24 ,  C07C43/225 ,  C07C43/29 ,  C07D233/56 ,  C07D233/58 ,  C07D249/08 ,  C07D303/08 ,  C07D521/00 ,  C07C17/24

Abstract: A method for stereoselective preparation of Z -1,2-diarylallylchlorides of the general formula where R1 and R2 independently one of another are hydrogen, halogen, alkyl, halogenalkyl, alkoxy, halogenalkoxy or unsubstituted or substituted aromatic residue, n and m =1,2 or 3. chlorohydrins of the general formula where R1 and R2 having above mentioned value are dehydrated in the inert ether or ester of carboxylic acid and as solvent in the presence of anhydride of carboxylic acid or respective ketene and organic or inorganic acid or oleum at temperatures to 50 °C.

公开(公告)号：RU2125997C1

公开(公告)日：1999-02-10

申请号：RU94011635

申请日：1991-11-26

Applicant: BASF AG

Inventor： RAJNER KOBER ,  RAJNER SEELE ,  KHAJNTS ISAK ,  EHKKARD KHIKMANN ,  NORBERT GETTS ,  TOMAS TSIRKE

IPC: C07C17/35 ,  C07C17/357 ,  C07C25/24 ,  C07C43/225 ,  C07C43/29 ,  C07D233/56 ,  C07D233/58 ,  C07D249/08 ,  C07D303/08 ,  C07D521/00

Abstract: FIELD: agriculture. SUBSTANCE: present invention describes chloromethyldiaryloxiranes I: R R wherein and are independently hydrogen, halogen, n and m are 1,2 or 3, which are useful as intermediate products for synthesis of azolylmethyloxiranes having fungicidal activity. Compounds of formula I are prepared by epoxidation of corresponding diarylallyl chlorides III. Compounds of formula I make it possible to obtain final products with higher yield and less number of stages. EFFECT: improved properties of the title compounds. 2 cl, 1 dwg, 11 ex, 2 tbl

公开(公告)号：RU2096401C1

公开(公告)日：1997-11-20

申请号：SU5011959

申请日：1992-06-29

Applicant: BASF AG

Inventor： RAJNER KOBER ,  RAJNER SEELE ,  KHAJNTS ISAK ,  EKKARD KHIKMANN ,  NORBERT GETTS ,  TOMAS TSIRKE

IPC: C07B53/00 ,  C07C17/00 ,  C07C17/35 ,  C07C17/357 ,  C07C22/04 ,  C07C25/24 ,  C07C41/18 ,  C07C41/48 ,  C07C43/225 ,  C07C43/29 ,  C07D233/56 ,  C07D233/58 ,  C07D249/08 ,  C07D301/16 ,  C07D303/08 ,  C07D405/06 ,  C07D521/00

Abstract: Preparation of Z-1,2-diarylallyl chlorides of the general formula I in which the radicals R and R independently of one another are hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy or a substituted aromatic radical, and n and m represent 1, 2 or 3, by dehydrating chlorohydrins of the formula II in which the radicals have the abovementioned meanings, at temperatures of up to 50 DEG C in the presence of a carboxylic anhydride and of an organic or inorganic acid, in an inert ether or carboxylate as the solvent, the reaction of these products to give azolylmethyloxiranes, and novel intermediates.