公开(公告)号：DE2918778A1

公开(公告)日：1980-11-20

申请号：DE2918778

申请日：1979-05-10

Applicant: BASF AG

Inventor： STEINER GERD DIPL CHEM DR ,  FRANKE ALBRECHT DIPL CHEM DR ,  LENKE HANS-DIETER PROF DR ,  TESCHENDORF HANS JUERGEN DR ,  WORSTMANN WOLFGANG DR ,  KREISKOTT HORST DR

IPC: A61K31/55 ,  A61P25/18 ,  C07D223/20 ,  C07D401/06 ,  C07D403/04 ,  C07D498/04 ,  C07D401/04 ,  A61K31/395

Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.

公开(公告)号：DE2818999A1

公开(公告)日：1979-11-15

申请号：DE2818999

申请日：1978-04-29

Applicant: BASF AG

Inventor： THIEME PETER DR ,  FRICKEL FRITZ-FRIEDER DR ,  THEOBALD HANS DR ,  FRANKE ALBRECHT DR ,  LENKE HANS-DIETER PROF DR ,  GRIES JOSEF DR

IPC: A61K31/41 ,  A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08

Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

公开(公告)号：DE3134775A1

公开(公告)日：1983-03-10

申请号：DE3134775

申请日：1981-09-02

Applicant: BASF AG

Inventor： STEINER GERD DIPL CHEM DR ,  HOFMANN HANS-PETER DR ,  KREISKOTT HORST DR ,  TESCHENDORF HANS-JUERGEN DR ,  LENKE HANS-DIETER PROF DR

IPC: C07D295/155 ,  C07D241/04 ,  A61K31/495

Abstract: The invention relates to 5-cyanomethylenedibenzo[a,d]cycloheptenes which are substituted in the 10 position, to processes for their preparation, to therapeutic agents containing these compounds, and to their use as sedatives, hypnotic agents, tranquillisers and neuroleptic agents.

公开(公告)号：DE3009034A1

公开(公告)日：1981-09-24

申请号：DE3009034

申请日：1980-03-08

Applicant: BASF AG

Inventor： STEINER GERD DIPL CHEM DR ,  HOFMANN HANS PETER DR ,  KREISKOTT HORST DR ,  TESCHENDORF HANS JUERGEN DR ,  LENKE HANS-DIETER PROF DR

IPC: C07D295/14 ,  A61K31/275 ,  A61K31/395 ,  A61K31/50 ,  A61K31/55 ,  A61P25/20 ,  C07C67/00 ,  C07C253/00 ,  C07C255/37 ,  C07C255/42 ,  C07D243/08 ,  C07D295/08 ,  C07D295/155 ,  C07D295/04 ,  C07C121/48 ,  A61K31/00

Abstract: 10-Substituted 5-cyanomethylene-dibenzo[a,d]-cycloheptenes, their pure cis- and trans-isomers, their N-oxides and their pharmaceutically tolerated addition salts with acids, processes for their preparation, therapeutic agents containing these compounds and their use as drugs, especially as sedatives, hypnotics or tranquilizers.

公开(公告)号：DE2850078A1

公开(公告)日：1980-05-29

申请号：DE2850078

申请日：1978-11-18

Applicant: BASF AG

Inventor： FRANKE ALBRECHT DIPL CHEM DR ,  LENKE HANS-DIETER PROF DR ,  GRIES JOSEF DR ,  LEHMANN HANS DIETER DR

IPC: A61K31/55 ,  C07D223/16 ,  C07D405/12 ,  C07D223/10