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公开(公告)号：WO0142185A3
公开(公告)日：2002-05-02
申请号：PCT/EP0011817
申请日：2000-11-27
Applicant: BASF AG , GOETZ ROLAND , GOETZ NORBERT , KEIL MICHAEL , WOLF BERND , STEINMETZ ADRIAN , STAMM ARMIN , HENKELMANN JOCHEM
Inventor： GOETZ ROLAND , GOETZ NORBERT , KEIL MICHAEL , WOLF BERND , STEINMETZ ADRIAN , STAMM ARMIN , HENKELMANN JOCHEM
Abstract: The invention relates to a method for producing o-chloromethyl benzoic acid chlorides of formula (I), in which R to R can be the same or different and represent hydrogen C1-C4 alkyl, halogen or trifluoromethyl, by reacting benzo-condensed lactones of formula (II), in which R to R have the above-mentioned meaning, with thionyl chloride. The inventive method is characterized in that the reaction is carried out in the presence of catalytic quantities of a Lewis acid and in the presence of catalytic quantities of a phosphine derivative.
Abstract translation: 本发明涉及一种用于制备式（I），其中R <1> -R <4>相同或不同，并代表氢，C1-C4烷基，卤素或三氟甲基，由反应的邻 - 氯甲基苯甲酰氯 苯并稠合的式（II）的内酯，其中R <1> -R <4>具有上述含义，与亚硫酰氯，其特征在于，一个执行在路易斯酸催化量和催化量的膦的存在下进行反应。
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公开(公告)号：WO0031041A3
公开(公告)日：2000-11-09
申请号：PCT/EP9908515
申请日：1999-11-06
Applicant: BASF AG , MAYWALD VOLKER , STEINMETZ ADRIAN , RACK MICHAEL , GOETZ NORBERT , GOETZ ROLAND , HENKELMANN JOCHEM , BECKER HEIKE , AISCAR BAYETO JUAN JOSE
Inventor： MAYWALD VOLKER , STEINMETZ ADRIAN , RACK MICHAEL , GOETZ NORBERT , GOETZ ROLAND , HENKELMANN JOCHEM , BECKER HEIKE , AISCAR BAYETO JUAN JOSE
IPC: C07B61/00 , C07D231/20
CPC classification number: C07D231/20
Abstract: The invention relates to a method for the production of 1-substituted 5-hydroxypyrazoles of formula (I) wherein R is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C6-cycloalkyl or C1-C4-alkoxy, whereby these groups can be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or a cyclic ring system with 3-14 ring atoms, by reacting a) an alkylvinylether of general formula (III) wherein R is C1-C6-alkyl or C3-C6-cycloalkyl, with phosgene (IVa), "diphosgene" (IVb) or "triphosgene" (IVc) to form acid chlorides of formula (V), b) transforming said acid chlorides by eliminating hydrogen chloride into the corresponding 3-alkoxyacrylic acid chloride of formula (VI) and c) reacting said acid chloride with hydrazines of formula (VII) wherein R has the above cited meaning, to form 5-hydroxypyrazoles of formula (I).
Abstract translation: 本发明涉及一种制备1-取代的式（I）的5-羟基吡唑，其中R <1> C1-C6-烷基，C2-C6链烯基，C2-C6炔基，C3-C6环烷基，或 C1-C4烷氧基，其中这些基团被卤素，C1-C4烷氧基，苯氧基，C1-C6烷氧羰基，C1-C6烷硫基羰基或具有3-14个环原子的环系中，可以通过a）取代 通式烷基乙烯基醚（III）其中R <2> C 1 -C 6 - 烷基或C 3 -C 6 - 环烷基与光气（IVa）中，“双光气”（IVb）的或“三光气”（IVc）的下式的酰氯 （V），b）使由消除氯化氢转化成相应的式3-alkoxyacryloyl（VI）这和c）VII）其中R <1>具有上述这表明（与式肼至5的含义 式（I）的-Hydroxypyrazolen。
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公开(公告)号：WO0142182A3
公开(公告)日：2001-12-06
申请号：PCT/EP0011810
申请日：2000-11-27
Applicant: BASF AG , GOETZ ROLAND , GOETZ NORBERT , KEIL MICHAEL , WOLF BERND , STEINMETZ ADRIAN , STAMM ARMIN , HENKELMANN JOCHEM
Inventor： GOETZ ROLAND , GOETZ NORBERT , KEIL MICHAEL , WOLF BERND , STEINMETZ ADRIAN , STAMM ARMIN , HENKELMANN JOCHEM
Abstract: The invention relates to a method for producing o-chloromethyl benzoic acid chlorides of formula (I), in which R to R can be the same or different and represent hydrogen C1-C4 alkyl, halogen or trifluoromethyl, by reacting benzo-condensed lactones of formula (II), in which R to R have the above-mentioned meaning, with thionyl chloride. The inventive method is characterized in that the reaction is carried out in the presence of catalytic quantities of a boric acid, boric acid anhydride, borate, boronic acid or boronic acid ester and in the presence of catalytic quantities of a quaternary ammonia salt.
Abstract translation: 本发明涉及一种用于制备式（I）的邻 - 氯甲基苯甲酰氯，于R的处理<4>可以<1>是相同的或R不同，并代表氢，C1-C4烷基，卤素或三氟甲基，通过使 苯并稠合的式内酯（II），至R <4>具有R <1>如上所定义，与亚硫酰氯，其特征在于gekennzeichet，在催化量的硼酸，的存在下进行反应硼酸酐，硼酸盐，硼酸或Boronsäureester一个和 催化量的季铵盐。
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公开(公告)号：WO0031042A3
公开(公告)日：2000-10-26
申请号：PCT/EP9908516
申请日：1999-11-06
Applicant: BASF AG , MAYWALD VOLKER , STEINMETZ ADRIAN , RACK MICHAEL , GOETZ NORBERT , GOETZ ROLAND , HENKELMANN JOCHEM , BECKER HEIKE , AISCAR BAYETO JUAN JOSE
Inventor： MAYWALD VOLKER , STEINMETZ ADRIAN , RACK MICHAEL , GOETZ NORBERT , GOETZ ROLAND , HENKELMANN JOCHEM , BECKER HEIKE , AISCAR BAYETO JUAN JOSE
IPC: C07D231/20
CPC classification number: C07D231/20
Abstract: The invention relates to a method for producing 1-substituted 5- and/or 3-hydroxypyrazoles of formulas (I) and (II), wherein R represents C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C6-cycloalkyl or C1-C4-alkoxy, whereby these groups can be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or a cyclic ring system with 3-14 ring atoms, by reacting a 3-alkoxyacrylic acid alkyl ester of formula (III), wherein R , R independently mean C1-C6-alkyl or C3-C6-cycloalky, with a hydrazine of formula (IV), wherein R has the above cited meaning, a) at a pH value of 6-11 to form 5-hydroxypyrazoles of formula (I), or b) at a pH value of 11-14 to form 3-hydroxypyrazoles of formula (II).
Abstract translation: 本发明涉及一种制备1-取代的5和/或所述式（I）和（II），其中R <1> C1-C6-烷基，C2-C6链烯基，C2-C6的3-羟基吡 炔基，C3-C6环烷基或C1-C4烷氧基，其中这些基团被卤素，C1-C4烷氧基，苯氧基，C1-C6烷氧羰基，C1-C6烷硫基羰基或具有3-14个环原子的环系 可以由式（III）的烷基3- alkoxyacrylates被取代，其中R <2>，R <3>独立地是C1-C6烷基或C3-C6环烷基与式的肼（Ⅳ） 其中R <1>具有上面给出的含义，a）在pH值下式I）的6-11（约5-羟基吡唑反应而，或b）在pH为11-14，得到3- hydroxypyrazoles 的式（II）。
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公开(公告)号：SK286367B6
公开(公告)日：2008-08-05
申请号：SK6792001
申请日：1999-11-06
Applicant: BASF AG
Inventor： MAYWALD VOLKER , STEINMETZ ADRIAN , RACK MICHAEL , GOTZ NORBERT , GOTZ ROLAND , HENKELMANN JOCHEM , BECKER HEIKE , AISCAR BAYETO JUAN JOSE
IPC: C07D231/00 , C07D231/20
Abstract: It is described a method for producing 1-substituted 5- and/or 3-hydroxypyrazoles of formulas (I) and (II), wherein R1 represents C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkinyl, C3-C6-cycloalkyl or C1-C4-alkoxy, whereby these groups can be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or a cyclic ring system with 3-14 ring atoms, by reacting a 3-alkoxyacrylic acid alkyl ester of formula (III), wherein R2, R3 independently mean C1-C6-alkyl or C3-C6-cycloalky, with a hydrazine of formula (IV), wherein R1 has the above cited meaning, a) at a pH value of 6-11 to form 5-hydroxypyrazoles of formula (I), or b) at a pH value of 11-14 to form 3-hydroxypyrazoles of formula (II).
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Patent Agency Ranking
公开(公告)号：ES2215780T3
公开(公告)日：2004-10-16
申请号：ES00987303
申请日：2000-11-27
Applicant: BASF AG
Inventor： GITZ ROLAND , GITZ NORBERT , KEIL MICHAEL , WOLF BERND , STEINMETZ ADRIAN , STAMM ARMIN
Abstract: A process for preparing o-chloromethylbenzoyl chlorides of the formula I,in which R to R can be identical or different and are hydrogen, C1-C4-alkyl, halogen or trifluoromethyl, by reacting benzo-fused lactones of the formula II,in which R to R are as defined above, with thionyl chloride, which comprises carrying out the reaction in the presence of catalytic amounts of boric acid, boric anhydride, borate, boronic acid or boronic acid esters and catalytic amounts of a quaternary ammonium salt is described.
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公开(公告)号：PL357592A1
公开(公告)日：2004-07-26
申请号：PL35759200
申请日：2000-11-27
Applicant: BASF AG
Inventor： GOETZ ROLAND , GOETZ NORBERT , KEIL MICHAEL , WOLF BERND , STEINMETZ ADRIAN , STAMM ARMIN , HENKELMANN JOCHEM
Abstract: The invention relates to a method for producing o-chloromethyl benzoic acid chlorides of formula (I), in which R 1 to R 4 can be the same or different and represent hydrogen C 1 -C 4 alkyl, halogen or trifluoromethyl, by reaction benzo condensed lactones of formula (II), in which R 1 to R 4 have the above-mentioned meaning, with thionyl chloride. The inventive method is characterized in that the reaction is carried out in the presence of catalytic quantities of a Lewis acid and in the presence of catalytic quantities of a phosphine derivative.
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公开(公告)号：DE50006775D1
公开(公告)日：2004-07-15
申请号：DE50006775
申请日：2000-11-27
Applicant: BASF AG
Inventor： GOETZ ROLAND , GOETZ NORBERT , KEIL MICHAEL , WOLF BERND , STEINMETZ ADRIAN , STAMM ARMIN , HENKELMANN JOCHEM
Abstract: The invention relates to a method for producing o-chloromethyl benzoic acid chlorides of formula (I), in which R 1 to R 4 can be the same or different and represent hydrogen C 1 -C 4 alkyl, halogen or trifluoromethyl, by reaction benzo condensed lactones of formula (II), in which R 1 to R 4 have the above-mentioned meaning, with thionyl chloride. The inventive method is characterized in that the reaction is carried out in the presence of catalytic quantities of a Lewis acid and in the presence of catalytic quantities of a phosphine derivative.
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公开(公告)号：DK1131299T3
公开(公告)日：2004-02-02
申请号：DK99972625
申请日：1999-11-06
Applicant: BASF AG
Inventor： MAYWALD VOLKER , STEINMETZ ADRIAN , RACK MICHAEL , GOETZ NORBERT , GOETZ ROLAND , HENKELMANN JOCHEM , AISCAR BAYETO JUAN JOSE , BECKER HEIKE
IPC: C07D231/20
Abstract: The invention relates to a process for preparing 1-substituted 5- and/or 3-hydroxypyrazoles of the formulae I and IIin which R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl or C1-C4-alkoxy, where these groups may be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or by a cyclic ring system having 3-14 ring atoms, which comprises reactingan alkyl 3-alkoxyacrylate of the formula IIIin which R2, R3 independently of one another are C1-C6-alkyl or C3-C6-cycloalkyl with a hydrazine of the formula IVin which R1 is as defined abovea) at a pH of 6-11 to give 5-hydroxypyrazoles of the formula I orb) at a pH of 11-14 to give 3-hydroxypyrazoles of the formula II.
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公开(公告)号：BR9915492A
公开(公告)日：2001-08-07
申请号：BR9915492
申请日：1999-11-06
Applicant: BASF AG
Inventor： MAYWALD VOLKER , STEINMETZ ADRIAN , RACK MICHAEL , TZ NORBERT G , TZ ROLAND G , HENKELMANN JOCHEM , BECKER HEIKE , BAYETO JUAN JOSE AISCAR
IPC: C07D231/20
Abstract: The invention relates to a process for preparing 1-substituted 5- and/or 3-hydroxypyrazoles of the formulae I and IIin which R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl or C1-C4-alkoxy, where these groups may be substituted by halogen, C1-C4-alkoxy, phenoxy, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl or by a cyclic ring system having 3-14 ring atoms, which comprises reactingan alkyl 3-alkoxyacrylate of the formula IIIin which R2, R3 independently of one another are C1-C6-alkyl or C3-C6-cycloalkyl with a hydrazine of the formula IVin which R1 is as defined abovea) at a pH of 6-11 to give 5-hydroxypyrazoles of the formula I orb) at a pH of 11-14 to give 3-hydroxypyrazoles of the formula II.
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