公开(公告)号：DE4411225A1

公开(公告)日：1995-10-05

申请号：DE4411225

申请日：1994-03-31

Applicant: BASF AG

Inventor： BAUMANN ERNST DR ,  VOGELBACHER UWE JOSEF DR ,  RHEINHEIMER JOACHM DR ,  KLINGE DAGMAR DR ,  RIECHERS HARTMUT DR ,  KROEGER BURKHARD DR ,  BIALOJAN SIEGFRIED DR ,  BOLLSCHWEILER CLAUS DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/26 ,  A61K31/00 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  A61P39/02 ,  C07D239/26 ,  C07D239/34 ,  C07D239/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The invention concerns the use of carboxylic acid derivatives of formula I (I) in which R means a formyl group, a CO2H group or a residue which can be hydrolysed to form COOH; X means nitrogen or CR , wherein R means hydrogen or, together with R , forms a 3- to 4-member alkylene or alkenylene chain in each of which a methyl group can be replaced by oxygen; Y means sulphur or oxygen or a single bond; Z means sulphur or oxygen; and the other substituents have the meanings given in the description. These derivatives can be used for preparing medicaments.

公开(公告)号：CZ9701132A3

公开(公告)日：1998-03-18

申请号：CZ113297

申请日：1995-10-07

Applicant: BASF AG

Inventor： RIECHERS HARTMUT DR ,  KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  MULLER STEFAN DR ,  BAUMANN ERNST DR ,  RHEINHEIMER JOACHIM DR ,  VOGELBACHER JOSEF UWE DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  A61K31/495

CPC classification number: C07D495/04 ,  C07D239/34 ,  C07D239/48 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/20 ,  C07D251/26 ,  C07D251/52 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048

公开(公告)号：DE4404249A1

公开(公告)日：1995-08-17

申请号：DE4404249

申请日：1994-02-10

Applicant: BASF AG

Inventor： TREIBER HANS-JOERG DR ,  WERNET WOLFGANG DR ,  EMILIO CLEMENTI DR ,  JACOPO MELDOLESI PROF ,  POMPEO VOLPE PROF

IPC: C07D295/084 ,  C07D295/092 ,  C07B37/02 ,  C07B41/00

Abstract: Substd. cycloalkyl-piperazinyl-ethanol cpds. (I) and their salts are new. R1, R2 = H, halo or OMe; A = 1-3C alkylene or 2-3C alkenylene; Q = bond, O, S or benzyl (opt. substd. by R1); n = 1 or 2.

公开(公告)号：DE4341663A1

公开(公告)日：1995-06-08

申请号：DE4341663

申请日：1993-12-07

Applicant: BASF AG

Inventor： UNGER LILIANE DR ,  RASCHACK MANFRED DR ,  WERNET WOLFGANG DR ,  BOEHM HANS-JOACHIM DR ,  RIECHERS HARTMUT DR

IPC: C07C205/26 ,  C07C205/37 ,  C07D241/44 ,  C07D401/06 ,  C07D403/06 ,  C07D241/52 ,  C07D487/04

Abstract: Bicyclic piperazinone derivs. of formula (I) and their salts are new. Two of A, B, D and E are CH and the other two are CH or N; G = 1-6C alkyl, (CH2)nG', COR1 or SO2R1; n = 0-4; G' = phenyl (opt. mono- or disubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3), heteroaryl (opt. monosubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3) or 3-6C cycloalkyl (opt. substd. by 1-3C alkyl); R1 = H or 1-6C alkyl; M, Q = a direct bond, 1-6C n-alkylene (opt. substd. by 1-6C alkyl or Ar) or CH=CH; Ar = phenyl (opt. mono- or disubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3) or heteroaryl (opt. monosubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3); L, T = COOR3, CONR3R4 or SO2OR3; R3 and R4 = H, 1-6C alkyl, OR5 or SR5; R5 = 1-6C alkyl or Ar; X, Y = H, 1-6C alkyl, 1-6C alkoxy or 1-6C alkylthio, phenyl or benzyl (both opt. mono- or disubstd. by OH, 1-4C alkyl, 1-4C alkoxy, halogen or CF3) or CONR3R4 or SO2NR3R4.

公开(公告)号：CZ113297A3

公开(公告)日：1998-03-18

申请号：CZ113297

申请日：1995-10-07

Applicant: BASF AG

Inventor： RIECHERS HARTMUT DR ,  KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  MULLER STEFAN DR ,  BAUMANN ERNST DR ,  RHEINHEIMER JOACHIM DR ,  VOGELBACHER JOSEF UWE DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  A61K31/495

Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.

公开(公告)号：DE4341666A1

公开(公告)日：1995-06-08

申请号：DE4341666

申请日：1993-12-07

Applicant: BASF AG

Inventor： ALBRECHT HANS-PETER DR ,  BOEHM HANS-JOACHIM DR ,  RASCHACK MANFRED DR ,  UNGER LILIANE DR ,  WERNET WOLFGANG DR

IPC: C07C62/06 ,  C07C62/18 ,  C07C62/38 ,  C07C69/757 ,  C07C205/56 ,  C07C229/46 ,  C07C229/50 ,  C07C235/34 ,  C07D209/18 ,  C07C69/753 ,  C07C205/11 ,  C07C245/24 ,  C07D213/74

公开(公告)号：DE19533023A1

公开(公告)日：1996-04-18

申请号：DE19533023

申请日：1995-09-07

Applicant: BASF AG

Inventor： RIECHERS HARTMUT DR ,  KLINGE DAGMAR DR ,  AMBERG WILHELM DR ,  KLING ANDREAS DR ,  MUELLER STEFAN DR ,  BAUMANN ERNST DR ,  RHEINHEIMER JOACHIM DR ,  VOGELBACHER UWE JOSEF DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: C07D251/30 ,  A61K31/505 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  A61P25/04 ,  C07D239/00 ,  C07D239/26 ,  C07D239/28 ,  C07D239/34 ,  C07D239/38 ,  C07D239/60 ,  C07D239/70 ,  C07D239/96 ,  C07D251/12 ,  C07D251/52 ,  C07D257/02 ,  C07D309/00 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12 ,  C07D487/04 ,  C07D491/04 ,  C07D491/044 ,  C07D491/048 ,  C07D495/04 ,  C07D409/12 ,  C07D413/12 ,  A61K31/41

Abstract: Carboxylic acid derivatives have the formula (I), in which R to R , X, Y, and Z have the meanings given in the description. Also disclosed is their preparation. These new compounds are useful for controlling diseases.

公开(公告)号：DE4341665A1

公开(公告)日：1995-06-08

申请号：DE4341665

申请日：1993-12-07

Applicant: BASF AG

Inventor： KLINGE DAGMAR DR ,  WERNET WOLFGANG DR ,  UNGER LILIANE DR ,  RASCHACK MANFRED DR

IPC: A61K31/505 ,  A61K31/55 ,  A61P9/00 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00 ,  C07D239/96 ,  C07D243/14 ,  C07D243/28 ,  C07D403/04 ,  C07D403/06 ,  C07D487/04 ,  C07D243/30

Abstract: PCT No. PCT/EP94/03980 Sec. 371 Date Jun. 6, 1996 Sec. 102(e) Date Jun. 6, 1996 PCT Filed Nov. 30, 1994 PCT Pub. No. WO95/15963 PCT Pub. Date Jun. 15, 1995The description relates to bicyclene derivatives of formula (I) in which A, B, D, E, G, K, L, R1, R2, Z1 and Z2 have the meanings given in the description, and their production. These compounds are suitable for treating diseases. (I)