公开(公告)号：JP2002204700A

公开(公告)日：2002-07-23

申请号：JP2001393020

申请日：2001-12-26

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN R

IPC: B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  C12N7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569

Abstract: PROBLEM TO BE SOLVED: To provide a method for validating the deactivation treatment of infectious virus in blood components. SOLUTION: This method for validating a virus deactivating process is characterized by comprising the steps of treating virally contaminated blood components by the virus deactivating process, adding virus host cells to the thus treated blood components, filtering the resultant blood components for removing the virus host cells, and testing the virus host cells for viral contamination.

公开(公告)号：WO9427698A3

公开(公告)日：1996-10-10

申请号：PCT/US9305735

申请日：1993-06-15

Applicant: BAXTER INT

Inventor： LAKE WILLIAM C ,  GIESLER RICHARD ,  VAN EPPS DENNIS ,  CHAPMAN JOHN R ,  MARTINSON JEFFREY A ,  ELLIS DALE R ,  AONO FREDERICK ,  BISCHOF DANIEL F

IPC: G01N33/48 ,  A61K35/14 ,  A61K35/24 ,  A61M1/36 ,  B03B5/28 ,  C12M1/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  B01D

CPC classification number: G01N33/56972 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  C12Q1/24 ,  G01N33/5005 ,  G01N33/569

Abstract: A method combining the techniques of immunoaffinity separation and continuous flow centrifugal separation is provided for selective separation of a nucleated heterogeneous cell population from a heterogeneous cell mixture. The heterogeneous cell mixture is intimately contacted to promote binding thereto by particles having attached a substance that actively binds to a specific desired type of cell out of the cell mixture. The particles are selected so that the sedimentation velocity of the particle/cell conjugate differs sufficiently from those of other cells in the cell mixture to allow its separation by means of a continuous flow cell separator. The method rapidly processes large volumes of cell mixture with the high accuracy expected of immunoaffinity separation and can be used to separate, for example, various types of leukocytes from whole blood, bone marrow concentrate, or a peripheral blood stem cell concentrate; or precursors of lymphokine activated killer cells, tumor infiltrating lymphocyte cells, or activated killer monocytes from lymphocyte or monocyte cell concentrates or from a tissue cell preparation.

公开(公告)号：EP0885018A4

公开(公告)日：2001-02-07

申请号：EP97911794

申请日：1997-10-23

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN R ,  STARK PETER R H ,  REED MICHAEL A ,  LARSON DALE N ,  CUFFARO DANIEL F

IPC: A61L2/08 ,  A01N1/02 ,  A61K35/16 ,  A61L2/00 ,  A61M1/36 ,  C12N7/04 ,  H01J37/20

CPC classification number: A61M1/3681 ,  A61L2/0011 ,  A61M1/3683

公开(公告)号：EP0587832A4

公开(公告)日：1998-07-29

申请号：EP93905006

申请日：1993-02-09

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN R

IPC: B01D17/02 ,  B01D21/24 ,  B01D21/26 ,  C12N7/00 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569

CPC classification number: G01N33/56972 ,  B01D17/0217 ,  B01D21/0012 ,  B01D21/2405 ,  B01D21/2444 ,  B01D21/245 ,  B01D21/26 ,  B01D2221/10 ,  C12Q1/6806 ,  C12Q1/70 ,  G01N33/491 ,  G01N33/5091 ,  G01N33/5094

Abstract: The present invention provides a method for testing a blood unit for viral contamination without rendering the blood unit unusable for therapeutic applications. The method comprises the steps of: removing and collecting from a blood unit a majority of the leukocytes present therein with a leukocyte filter; and using the leukocytes collected in and on the filter to test the blood unit for viral contamination. The present invention also provides a method for validating viral inactivation processes.

公开(公告)号：EP0653062A4

公开(公告)日：1997-12-03

申请号：EP93915369

申请日：1993-06-15

Applicant: BAXTER INT

Inventor： LAKE WILLIAM C ,  GIESLER RICHARD ,  VAN EPPS DENNIS ,  CHAPMAN JOHN R ,  MARTINSON JEFFREY A ,  ELLIS DALE R ,  AONO FREDERICK ,  BISCHOF DANIEL F

IPC: G01N33/48 ,  A61K35/14 ,  A61K35/24 ,  A61M1/36 ,  B03B5/28 ,  C12M1/00 ,  C12N5/00 ,  C12N5/06 ,  C12Q1/02 ,  C12Q1/24 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569

CPC classification number: G01N33/56972 ,  A61M1/3618 ,  A61M1/362 ,  A61M1/3696 ,  C12Q1/24 ,  G01N33/5005 ,  G01N33/569

公开(公告)号：EP1079868A4

公开(公告)日：2003-03-19

申请号：EP99925587

申请日：1999-05-10

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN R ,  STARK PETER R H ,  SWALLOW MICHAEL V ,  LARSON DALE N

IPC: A61L2/08 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61M1/36 ,  C12N7/04 ,  H01J37/20 ,  A61L2/10 ,  A61L2/16 ,  A61L2/26

CPC classification number: A61M1/3681 ,  A61L2/0011 ,  A61M1/3683

公开(公告)号：CA2331404C

公开(公告)日：2008-11-18

申请号：CA2331404

申请日：1999-05-10

Applicant: BAXTER INT

Inventor： STARK PETER R H ,  CHAPMAN JOHN R ,  LARSON DALE N ,  SWALLOW MICHAEL V

IPC: A61L2/08 ,  A61L2/10 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61M1/36 ,  C12N7/04 ,  H01J37/20

Abstract: Apparatus (10) and methods for treating a biological fluid with light and for inactivating contaminants in biological fluid. The biological fluid is contacted with a light source providing a high intensity light to the biological fluid. The biological fluid may include a quantity of a photochemical agent that when activated by light is operable to cause inactivation of at least some of the contaminants. The apparatus (10) includes a housing (12) having a cover (14), a midportion (16), and a bottom portion (18).

公开(公告)号：ES2275343T3

公开(公告)日：2007-06-01

申请号：ES99925587

申请日：1999-05-10

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN R ,  STARK PETER R H ,  SWALLOW MICHAEL V ,  LARSON DALE N

IPC: A61L2/08 ,  A61L2/10 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61L2/16 ,  A61L2/26 ,  A61M1/36 ,  C12N7/04 ,  H01J37/20

Abstract: Aparato (70) para inactivar contaminantes de un fluido biológico, que comprende: - una primera fuente luminosa de alta intensidad (96) para proporcionar luz con una intensidad de al menos 80 mW/cm2 en un rango de longitudes de onda de entre 550 y 700 nm; - una segunda fuente luminosa de alta intensidad (96) para proporcionar luz con una intensidad de al menos 80 mW/cm2 en un rango de longitudes de onda de entre 550 y 700 nm; y - una zona de tratamiento de fluidos (100) situada entre dichas fuentes luminosas primera y segunda, estando cada una de las mencionadas fuentes luminosas separada de dicha zona de tratamiento de fluidos por una ventana (120) que transmite sustancialmente la luz en dicho rango de longitudes de onda aunque no transmite sustancialmente luz no deseada seleccionada.

公开(公告)号：AT214620T

公开(公告)日：2002-04-15

申请号：AT95943095

申请日：1995-12-08

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN R ,  LO YING-CHENG ,  KUBEY WINNIE ,  HOLMES CLIFFORD J ,  BELL DAVID

IPC: A61L2/16 ,  A01N25/10 ,  A01N25/34 ,  A01N59/00 ,  A01N59/12 ,  A61L2/00 ,  A61L29/00 ,  A61L29/16 ,  A61L31/00 ,  A61L31/16 ,  B01D67/00 ,  C08J7/06 ,  C08K3/00 ,  C08K3/10 ,  C08K3/16 ,  C08L23/00 ,  C08L25/04 ,  C08L67/00 ,  C08L67/02 ,  C08L69/00 ,  C08L101/00

Abstract: An antimicrobial material incorporated with a molecular halogen is provided. The antimicrobial material includes a plastic material and a molecular halogen entrapped within the plastic material. A directional release material is also provided in the present application. The directional release material allows for the control of the rate and site of halogen release. Still further, method of impregnating a plastic material is also provided.

公开(公告)号：NO20005800A

公开(公告)日：2001-01-11

申请号：NO20005800

申请日：2000-11-16

Applicant: BAXTER INT

Inventor： CHAPMAN JOHN R ,  STARK PETER R H ,  SWALLOW MICHAEL V ,  LARSON DALE N

IPC: A61L2/08 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61L2/00 ,  A61M1/36 ,  C12N7/04 ,  H01J37/20 ,  A61L2/10 ,  A61L2/16

CPC classification number: A61M1/3681 ,  A61L2/0011 ,  A61M1/3683