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公开(公告)号：WO2016048304A1
公开(公告)日：2016-03-31
申请号：PCT/US2014/057249
申请日：2014-09-24
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： SCHAEFFER-KORBYLO, Lyndsay , WON, Betty , MALONEY, Venda , SZEWCZYK, Gregory
CPC classification number: C12Q1/18 , C12Q2304/22 , C12Q2304/24
Abstract: Provided herein is a method for determining the bioavailability of a metal ion in a composition comprising a source of the metal ion, wherein the metal ion has antimicrobial activity, and wherein the method comprises: a) incubating a sample of the composition with bacterial cells, and b) determining the viability of the bacterial cells after incubation. The method is useful for determining the effect of agents on the bioavailability of metal ions in a composition.
Abstract translation: 本文提供了一种用于测定包含金属离子源的组合物中金属离子的生物利用度的方法，其中金属离子具有抗微生物活性，并且其中所述方法包括：a）将组合物的样品与细菌细胞孵育， 和b）测定孵育后细菌细胞的活力。 该方法可用于确定试剂对组合物中金属离子的生物利用度的影响。
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公开(公告)号：WO2017112667A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067773
申请日：2016-12-20
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： SZEWCZYK, Gregory , MANUS, Lisa , SCHAEFFER-KORBYLO, Lyndsay , POTANIN, Andrei , SUBRAMANYAM, Ravi
CPC classification number: A61K8/27 , A61K8/21 , A61K8/24 , A61K8/44 , A61K8/8176 , A61K8/8182 , A61K2800/58 , A61Q11/00 , A61Q11/02
Abstract: Disclosed herein are oral care compositions comprising a zinc amino acid halide complex, and linear polyvinylpyrrolidone and/or sodium tripolyphosphate, which compositions have improved rheological stability. Methods of making and using the compositions are also provided.
Abstract translation: 本文公开了包含锌氨基酸卤化物配合物和线性聚乙烯吡咯烷酮和/或三聚磷酸钠的口腔护理组合物，所述组合物具有改善的流变稳定性。 还提供了制造和使用该组合物的方法。
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公开(公告)号：WO2014151567A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026013
申请日：2014-03-13
Applicant: COLGATE-PALMOLIVE COMPANY , THE FORSYTH INSTITUTE
Inventor： SCHAEFFER-KORBYLO, Lyndsay , FRIAS-LOPEZ, Jorge
IPC: C07H3/08 , A61K8/49 , A61Q11/00 , C07H5/02 , C07H5/06 , A61K31/70 , A61K31/7004 , A61K31/7008 , A61P31/04
CPC classification number: A61K8/60 , A61K8/69 , A61K2800/591 , A61Q11/00 , C07H3/08 , C07H5/02 , C07H5/06
Abstract: Described herein are oral care compositions comprising a deoxy sugar antimetabolite and methods of inhibiting microbial biofilm formation and/or degrading a microbial biofilm in a subject.
Abstract translation: 本文描述了包含脱氧糖抗代谢物的口腔护理组合物和抑制受试者中微生物生物膜形成和/或降解微生物生物膜的方法。
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公开(公告)号：WO2017014723A1
公开(公告)日：2017-01-26
申请号：PCT/US2015/040927
申请日：2015-07-17
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： KINSCHERF, Kevin , SCHAEFFER-KORBYLO, Lyndsay , SZEWCZYK, Gregory , MYERS, Carl , TRIVEDI, Harsh
CPC classification number: A61Q11/00 , A61K8/27 , A61K8/30 , A61K8/463 , A61K9/08 , A61K33/00 , A61K33/30 , A61K45/06 , A61K47/34 , A61K2300/00
Abstract: An oral care composition comprising a surfactant having formula [R(OC 2 H 4 ) x OSO 3 ] 2 M wherein R is a saturated or unsaturated alkyl group with an alkyl chain length of 8 to 30 carbon atoms; x is from 0 to 10; and M is a divalent metal cation selected from zinc cations, copper cations and stannous cations is provided.
Abstract translation: 一种含有式[R（OC 2 H 4）x OSO 3] 2M表面活性剂的口腔护理组合物，其中R是烷基链长度为8-30个碳原子的饱和或不饱和烷基; x为0〜10; 并且M是选自锌阳离子，铜阳离子和亚锡阳离子的二价金属阳离子。
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公开(公告)号：WO2016100381A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/065879
申请日：2015-12-15
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： JARACZ, Stanislav , TRIVEDI, Harsh M. , SCHAEFFER-KORBYLO, Lyndsay
CPC classification number: A61K8/27 , A61K8/362 , A61K8/365 , A61K2800/92 , A61Q11/00
Abstract: The disclosure provides oral care compositions comprising zinc ions and citrate ions with molar ratios which unexpectedly high zinc bioavailability, together with methods of preparing and using the same.
Abstract translation: 本公开提供包含锌离子和柠檬酸根离子的口腔护理组合物，其摩尔比为意外高的锌生物利用度，以及制备和使用它们的方法。
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Patent Agency Ranking
公开(公告)号：WO2022251626A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/031334
申请日：2022-05-27
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： SCHAEFFER-KORBYLO, Lyndsay , MYERS, Carl , GOVINDARAJU, Gokul , PAUL, Reeba
Abstract: In one aspect, the application relates to novel aqueous oral care compositions useful for combining and delivering potassium salts and a basic amino acid in a high-water composition, for example, to naturally promote nitrate reduction from the oral microbiome, which can result in systemic increases of nitric oxide in blood plasma and can form part of an overall regimen to maintain, reduce, treat or control systemic blood pressure.
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公开(公告)号：WO2022140281A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064402
申请日：2021-12-20
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： SCHAEFFER-KORBYLO, Lyndsay , MYERS, Carl , GOVINDARAJU, Gokul , PAUL, Reeba
Abstract: The application relates to novel aqueous oral care compositions useful for combining and delivering incompatible stannous fluoride or stannous chloride or stannous pyrophosphate, potassium salts, and an amino acid (e.g., a basic amino acid) in a high-water composition, for example, to provide effective caries prevention, protection against dental erosion, and relief from dental hypersensitivity. Additionally, oral care compositions described here useful in order to naturally promote nitrate reduction from the oral microbiome, which can eventually result in systemic increases of nitric oxide in blood plasma, and can form part of an overall regimen to maintain or control blood pressure. Compositions comprise stannous fluoride, stannous chloride or stannous pyrophosphate, nitric acid or a water-soluble nitrate salt such as potassium nitrate, a water-soluble alkali metal polyphosphate such as tetrasodium pyrophosphate or trisodium polyphosphate, a basic amino aid such as arginine and more than 10 wt% water.
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公开(公告)号：WO2013095439A1
公开(公告)日：2013-06-27
申请号：PCT/US2011/066503
申请日：2011-12-21
Applicant: COLGATE-PALMOLIVE COMPANY , SCHAEFFER-KORBYLO, Lyndsay , NESTA, Jason , DU-THUMM, Laurence
Inventor： SCHAEFFER-KORBYLO, Lyndsay , NESTA, Jason , DU-THUMM, Laurence
CPC classification number: A61K8/66 , A61K2800/5922 , A61Q11/00
Abstract: Described herein are oral care compositions comprising an effective amount of an enzyme cocktail, wherein the enzyme cocktail comprises an alkaline protease and a second enzyme selected from cellulase, α-glucanase, and combinations thereof, in an orally acceptable carrier, together with methods of making and using the same.
Abstract translation: 本文描述了包含有效量的酶混合物的口腔护理组合物，其中所述酶混合物包含碱性蛋白酶和选自纤维素酶，α-葡聚糖酶及其组合的第二种酶，在口腔可接受的载体中，以及制备方法 并使用相同的。
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9.发明申请
公开(公告)号：WO2022140368A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064587
申请日：2021-12-21
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： GOVINDARAJU, Gokul , MYERS, Carl , SCHAEFFER-KORBYLO, Lyndsay
Abstract: This application relates to novel aqueous oral care compositions useful for combining and delivering incompatible stannous pyrophosphate and potassium salts in a high-water composition, for example, to provide effective caries prevention, protection against dental erosion, relief from dental hypersensitivity, and to treat or reduce malodor. The compositions comprise stannous pyrophosphate, nitric acid or a water-soluble nitrate salt, a water-soluble alkali metal polyphosphate and more than 10% water, by weight of the composition.
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公开(公告)号：WO2017100116A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/064903
申请日：2016-12-05
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： SCHAEFFER-KORBYLO, Lyndsay , MANUS, Lisa
IPC: A61K8/27 , A61K8/44 , A61Q11/02 , A61K33/00 , A61K31/198
CPC classification number: A61K8/58 , A61K8/27 , A61K8/44 , A61K2800/58 , A61Q11/00 , A61Q11/02 , A61K31/198 , A61K2300/00 , A61K33/30 , A61K33/34
Abstract: Disclosed herein are methods of promoting the aggregation and/or immune clearance of oral bacteria using oral care compositions comprising metal-amino acid complexes.
Abstract translation: 本文公开了使用包含金属 - 氨基酸复合物的口腔护理组合物促进口腔细菌的聚集和/或免疫清除的方法。
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