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公开(公告)号：WO2017000837A1
公开(公告)日：2017-01-05
申请号：PCT/CN2016/086995
申请日：2016-06-24
Applicant: COLGATE-PALMOLIVE COMPANY , HUANG, Xiaoyi
Inventor： HUANG, Xiaoyi , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , PATEL, Vyoma , WON, Betty , YAN, Peng , MORGAN, Andre Michelle
CPC classification number: A61K8/44 , A61K8/21 , A61K8/25 , A61K8/27 , A61K8/345 , A61K8/362 , A61K8/365 , A61K2800/28 , A61K2800/92 , A61Q11/00
Abstract: An oral care composition comprises arginine or lysine, zinc citrate and zinc oxide, a fluoride source, and glycerin, as well as to methods of using and of making the composition.
Abstract translation: 口腔护理组合物包含精氨酸或赖氨酸，柠檬酸锌和氧化锌，氟化物源和甘油，以及使用和制备组合物的方法。
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公开(公告)号：WO2016048304A1
公开(公告)日：2016-03-31
申请号：PCT/US2014/057249
申请日：2014-09-24
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： SCHAEFFER-KORBYLO, Lyndsay , WON, Betty , MALONEY, Venda , SZEWCZYK, Gregory
CPC classification number: C12Q1/18 , C12Q2304/22 , C12Q2304/24
Abstract: Provided herein is a method for determining the bioavailability of a metal ion in a composition comprising a source of the metal ion, wherein the metal ion has antimicrobial activity, and wherein the method comprises: a) incubating a sample of the composition with bacterial cells, and b) determining the viability of the bacterial cells after incubation. The method is useful for determining the effect of agents on the bioavailability of metal ions in a composition.
Abstract translation: 本文提供了一种用于测定包含金属离子源的组合物中金属离子的生物利用度的方法，其中金属离子具有抗微生物活性，并且其中所述方法包括：a）将组合物的样品与细菌细胞孵育， 和b）测定孵育后细菌细胞的活力。 该方法可用于确定试剂对组合物中金属离子的生物利用度的影响。
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3.发明申请
公开(公告)号：WO2015095627A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071335
申请日：2014-12-19
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： PRENCIPE, Michael , XU, Yun , HUANG, Xiao Yi , FISHER, Steven , WON, Betty
CPC classification number: A61K8/27 , A61K2800/5922 , A61Q11/00
Abstract: Described herein are oral care compositions comprising a combination of zinc oxide and zinc citrate, and methods of preparing and using the same.
Abstract translation: 本文描述了包含氧化锌和柠檬酸锌的组合的口腔护理组合物及其制备和使用方法。
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公开(公告)号：WO2010138547A3
公开(公告)日：2010-12-02
申请号：PCT/US2010/036143
申请日：2010-05-26
Applicant: COLGATE-PALMOLIVE COMPANY , MARTINETTI, Melissa , BOYD, Thomas , BROWN, James R. , WON, Betty , PILCH, Shira , MASTERS, James Gerard , PIMENTA, Paloma
Inventor： MARTINETTI, Melissa , BOYD, Thomas , BROWN, James R. , WON, Betty , PILCH, Shira , MASTERS, James Gerard , PIMENTA, Paloma
IPC: A61K8/27
Abstract: Described herein are polymer matrix films, compositions comprising the polymer matrix films, and methods of preparing and using the same.
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公开(公告)号：WO2022251438A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/031051
申请日：2022-05-26
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： NAKAJIMA, Murilo, Nogueira , TANG, Saide , WON, Betty , UTIMA, Enzo , XU, Guofeng , PIMENTA, Paloma , MELLO, Sarita , MUIR, Melissa
Abstract: This application provides, among other things, oral care compositions where the addition of a stabilizing amount of a nonionic gelling and thickening agent, (e.g., hydroxyethyl cellulose (HEC)), to formulations comprising a bisbiguanidine (e.g., chlorhexidine (CHX)) agent allows for proper structure and consistency to the formulation and to allow it to be used as a gel or a toothpaste to facility delivery of chlorhexidine, among other actives, to the teeth or gums.
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Patent Agency Ranking
公开(公告)号：WO2017219339A1
公开(公告)日：2017-12-28
申请号：PCT/CN2016/086994
申请日：2016-06-24
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , WON, Betty , MANUS, Lisa , STRANICK, Michael A. , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre Michelle , POTANIN, Andrei , HUANG, Xiaoyi
Abstract: An oral care composition comprises (a) arginine or lysine; (b) zinc citrate and zinc oxide; (c) fluoride source; and (d) a silica abrasive which exhibits an acid pH when measured as an aqueous slurry. The composition is used in the manufacture of a product for application to the oral cavity of a subject in need thereof to improve oral health.
Abstract translation: 口腔护理组合物包含（a）精氨酸或赖氨酸; （b）柠檬酸锌和氧化锌; （c）氟化物源; 和（d）当以含水浆液测量时呈现酸性pH的二氧化硅研磨剂。 该组合物用于制造用于需要其的受试者的口腔以改善口腔健康的产品。
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7.发明申请
公开(公告)号：WO2012078134A1
公开(公告)日：2012-06-14
申请号：PCT/US2010/059156
申请日：2010-12-07
Applicant: COLGATE-PALMOLIVE COMPANY , WON, Betty , PIMENTA, Paloma , PILCH, Shira , MASTERS, James , HASSAN, Mahmoud , GU, Ben
Inventor： WON, Betty , PIMENTA, Paloma , PILCH, Shira , MASTERS, James , HASSAN, Mahmoud , GU, Ben
Abstract: Described herein are films comprising a zinc-containing compound and a film-stabilizing ingredient, for use in oral and personal care compositions.
Abstract translation: 本文描述了用于口腔和个人护理组合物的包含含锌化合物和膜稳定成分的薄膜。
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公开(公告)号：WO2022188083A1
公开(公告)日：2022-09-15
申请号：PCT/CN2021/080127
申请日：2021-03-11
Applicant: COLGATE-PALMOLIVE COMPANY , XU, Shaopeng
Inventor： YANG, Ying , XU, Guofeng , TRIVEDI, Harsh Mahendra , MASTERS, James , CHEN, Dandan , WON, Betty
Abstract: Methods of increasing sIgA levels in an individual's oral cavity are disclosed. The methods comprise applying effective amounts of zinc oxide, zinc citrate, and arginine. Methods of increasing the concentration of sIgA in the individual's mucosa pellicle in the oral cavity are disclosed. Methods of increasing phagocytotic activity of phagocytotic cells in the individual's oral cavity are also disclosed. In addition, methods of increasing levels of β-Defensin 1 in the individual's oral cavity are disclosed.
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公开(公告)号：WO2022098730A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/057861
申请日：2021-11-03
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： MANUS, Lisa , STEELE, Joseph , PICQUET, Guillaume , PADULA, Christine , CHEN, Dandan , WON, Betty , POTANIN, Andrei
Abstract: The present invention relates to oral hydrogel compositions, more particularly to thermosensitive gel compositions, which undergo a sol-gel transition in the oral cavity, and which optionally comprise therapeutic actives for sustained release.
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公开(公告)号：WO2017223497A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039084
申请日：2017-06-23
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： POTH, Tilo , POTANIN, Andrei , BLANVALET, Claude , WON, Betty , MANUS, Lisa , STRANICK, Michael A. , HUANG, Xiaoyi , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre Michelle
Abstract: Described herein are oral care compositions comprising an amino acid; a combination of zinc ion sources; and a thickening system comprising a nonionic cellulose ether having a molecular weight of from about 300,000 to about 350,000; and a polysaccharide gum; along with methods of making and using same.
Abstract translation: 本文描述了包含氨基酸的口腔护理组合物; 锌离子源的组合; 和增稠体系，其包含分子量为约300,000至约350,000的非离子纤维素醚; 和多糖胶; 以及制作和使用它们的方法。
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