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1.发明申请
公开(公告)号：WO2020131650A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/066437
申请日：2019-12-16
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： MANUS, Lisa , STRANICK, Michael , WU, Donghui
Abstract: Provided herein are methods of treating one or more symptoms of a gastric disorder in the oral cavity of a subject in need thereof, wherein the method comprises applying to the subjects teeth an oral care composition comprising a basic amino acid in free or salt form, wherein the basic amino acid is arginine (e.g., free form arginine); zinc oxide and zinc citrate; and an orally acceptable carrier.
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公开(公告)号：WO2017112667A1
公开(公告)日：2017-06-29
申请号：PCT/US2016/067773
申请日：2016-12-20
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： SZEWCZYK, Gregory , MANUS, Lisa , SCHAEFFER-KORBYLO, Lyndsay , POTANIN, Andrei , SUBRAMANYAM, Ravi
CPC classification number: A61K8/27 , A61K8/21 , A61K8/24 , A61K8/44 , A61K8/8176 , A61K8/8182 , A61K2800/58 , A61Q11/00 , A61Q11/02
Abstract: Disclosed herein are oral care compositions comprising a zinc amino acid halide complex, and linear polyvinylpyrrolidone and/or sodium tripolyphosphate, which compositions have improved rheological stability. Methods of making and using the compositions are also provided.
Abstract translation: 本文公开了包含锌氨基酸卤化物配合物和线性聚乙烯吡咯烷酮和/或三聚磷酸钠的口腔护理组合物，所述组合物具有改善的流变稳定性。 还提供了制造和使用该组合物的方法。
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3.发明申请
公开(公告)号：WO2020131616A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/066225
申请日：2019-12-13
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： MANUS, Lisa , STRANICK, Michael , WU, Donghui
Abstract: Provided herein are methods of treating one or more symptoms of a gastric disorder in the oral cavity of a subject in need thereof, wherein the method comprises applying to the subjects teeth an oral care composition comprising a basic amino acid in free or salt form, wherein the basic amino acid is arginine (e.g., free form arginine); zinc oxide and zinc citrate; and an orally acceptable carrier.
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公开(公告)号：WO2017219339A1
公开(公告)日：2017-12-28
申请号：PCT/CN2016/086994
申请日：2016-06-24
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , WON, Betty , MANUS, Lisa , STRANICK, Michael A. , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre Michelle , POTANIN, Andrei , HUANG, Xiaoyi
Abstract: An oral care composition comprises (a) arginine or lysine; (b) zinc citrate and zinc oxide; (c) fluoride source; and (d) a silica abrasive which exhibits an acid pH when measured as an aqueous slurry. The composition is used in the manufacture of a product for application to the oral cavity of a subject in need thereof to improve oral health.
Abstract translation: 口腔护理组合物包含（a）精氨酸或赖氨酸; （b）柠檬酸锌和氧化锌; （c）氟化物源; 和（d）当以含水浆液测量时呈现酸性pH的二氧化硅研磨剂。 该组合物用于制造用于需要其的受试者的口腔以改善口腔健康的产品。
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公开(公告)号：WO2017223496A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039080
申请日：2017-06-23
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： HUANG, Xiaoyi , JOSIAS, Wilbens , PRENCIPE, Michael , STRANICK, Michael, A. , WON, Betty , MAURAO, Marcella , RUSSO, Amy , MANUS, Lisa , STETTLER, Hansruedi , PATEL, Vyoma , MORGAN, Andre, Michelle , POTANIN, Andrei , TAN, Chengkang , YAN, Peng
Abstract: Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and from about 0.75 wt.% to about 2 wt.% of a chelating system; along with methods of making and using same.
Abstract translation: 本文描述了包含碱性氨基酸的口腔护理组合物; 锌离子源的组合; 和约0.75重量％至约2重量％的螯合体系; 以及制作和使用它们的方法。
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Patent Agency Ranking
公开(公告)号：WO2017223493A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039074
申请日：2017-06-23
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： PONTANIN, Andrei , POTH, Tilo , AHUJA, Amit , BLANVALET, Claude , WON, Betty , MANUS, Lisa , STRANICK, Michael, A. , HUANG, Xiaoyi , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre, Michelle
Abstract: Described herein are oral care compositions comprising a basic amino acid; a combination of zinc ion sources; and a thickening system comprising a nonionic cellulose ether having a viscosity, measured at 2% in water at 25 °C, of 4500 to 7500 cps; and a polysaccharide gum; along with methods of making and using same.
Abstract translation: 本文描述了包含碱性氨基酸的口腔护理组合物; 锌离子源的组合; 和包含非离子纤维素醚的增稠体系，所述非离子纤维素醚的粘度在25℃在水中2％时测量为4500-7500cps; 和多糖胶; 以及制作和使用它们的方法。
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公开(公告)号：WO2015195117A1
公开(公告)日：2015-12-23
申请号：PCT/US2014/042947
申请日：2014-06-18
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： FITZGERALD, Michael , CONVERY, Joseph , MANUS, Lisa , TRIVEDI, Harsh
IPC: C07F3/00
CPC classification number: C07F3/06 , C07B2200/13 , C07F3/003
Abstract: The disclosure provides an improved synthesis for a zinc-lysine complex having the formula [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + Cl - , in which a zinc compound selected from ZnO and ZnCl 2 , is reacted with a lysine compound selected from lysine and lysine•HCl, in aqueous acid. The disclosure also provides oral care and personal care compositions comprising the complex prepared by the synthesis, and methods of using these complexes and compositions.
Abstract translation: 本公开提供了具有式[Zn（C 6 H 14 N 2 O 2）2 Cl] + Cl-的锌 - 赖氨酸复合物的改进合成，其中选自ZnO和ZnCl 2的锌化合物与选自赖氨酸和赖氨酸的赖氨酸化合物反应•HCl ，在酸性水溶液中。 本公开还提供了包含通过合成制备的络合物的口腔护理和个人护理组合物，以及使用这些复合物和组合物的方法。
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公开(公告)号：WO2022184115A1
公开(公告)日：2022-09-09
申请号：PCT/CN2022/078926
申请日：2022-03-03
Applicant: COLGATE-PALMOLIVE COMPANY , XU, Shaopeng
Inventor： MANUS, Lisa , LEE, Jonghun , STEELE, Joseph , DENG, Yuzhi
Abstract: This invention relates to oral care compositions comprising zinc oxide and zinc citrate, and hyaluronic acid or an alkali metal hyaluronate polymer having a molecular weight greater than 100,000 Da (e.g., from 300kDa –700kDa), as well as to methods of using and of making these compositions.
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公开(公告)号：WO2022098730A1
公开(公告)日：2022-05-12
申请号：PCT/US2021/057861
申请日：2021-11-03
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： MANUS, Lisa , STEELE, Joseph , PICQUET, Guillaume , PADULA, Christine , CHEN, Dandan , WON, Betty , POTANIN, Andrei
Abstract: The present invention relates to oral hydrogel compositions, more particularly to thermosensitive gel compositions, which undergo a sol-gel transition in the oral cavity, and which optionally comprise therapeutic actives for sustained release.
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公开(公告)号：WO2017223497A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/039084
申请日：2017-06-23
Applicant: COLGATE-PALMOLIVE COMPANY
Inventor： POTH, Tilo , POTANIN, Andrei , BLANVALET, Claude , WON, Betty , MANUS, Lisa , STRANICK, Michael A. , HUANG, Xiaoyi , PRENCIPE, Michael , RUSSO, Amy , STETTLER, Hansruedi , YAN, Peng , TAN, Chengkang , PATEL, Vyoma , MORGAN, Andre Michelle
Abstract: Described herein are oral care compositions comprising an amino acid; a combination of zinc ion sources; and a thickening system comprising a nonionic cellulose ether having a molecular weight of from about 300,000 to about 350,000; and a polysaccharide gum; along with methods of making and using same.
Abstract translation: 本文描述了包含氨基酸的口腔护理组合物; 锌离子源的组合; 和增稠体系，其包含分子量为约300,000至约350,000的非离子纤维素醚; 和多糖胶; 以及制作和使用它们的方法。
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