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公开(公告)号：WO0119798A2
公开(公告)日：2001-03-22
申请号：PCT/US0025195
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , JIA ZHAOZHONG JON , HUANG WENRONG , SONG YONGHONG , KANTER JAMES , SCARBOROUGH ROBERT M
IPC: C07D231/14 , A61K31/33 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , A61P7/04 , A61P43/00 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/20 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07D231/00
CPC classification number: C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Compounds of formula A Q D E G J X in which D is a direct link, a substituted or unsubsituted phenyl or naphtyl gourp or a heterocyclic ring system; G is substituted or unsubstituted phenyl or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed, The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 其中D是直接键，取代或未取代的苯基或萘基金属或杂环系的式A Q D E G J X的化合物; G是取代或未取代的苯基或杂环系; X是取代或未取代的苯基或萘基或杂环系; 并且其它变量如权利要求中所定义，其公开的与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。该化合物在体外或体内可用于预防或治疗凝血障碍。
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2.发明申请PROCESS FOR THE PRODUCTION OF 4-QUINAZOLINYLPIPERAZIN-1-CARBOXYLIC ACID PHENYLAMIDES 审中-公开生产4-五氮杂环丁烷-1-羧酸苯甲酸的方法
公开(公告)号：WO0236587A3
公开(公告)日：2002-08-22
申请号：PCT/US0145400
申请日：2001-11-01
Applicant: COR THERAPEUTICS INC , KANTER JAMES , PANDEY ANJALI , ROBINSON JAMES , SCARBOROUGH ROBERT M
Inventor： KANTER JAMES , PANDEY ANJALI , ROBINSON JAMES , SCARBOROUGH ROBERT M
IPC: C07D239/86 , A61K31/517 , A61K31/5377 , A61P9/10 , A61P13/12 , A61P29/00 , A61P35/00 , A61P43/00 , C07B61/00 , C07D239/94
CPC classification number: C07D239/94
Abstract: The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and slats or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.
Abstract translation: 本发明提供含氮杂环化合物及其药学上可接受的盐及其制备方法。 这些化合物对抑制这种激酶活性的激酶的磷酸化具有抑制活性。 本发明还提供了可用于该方法的中间体化合物，以及由该方法生产的最终产物及其板条或前药。 本发明进一步提供了通过抑制激酶的磷酸化来抑制哺乳动物激酶和治疗疾病状态的方法，包括向有需要的患者施用有效量的本发明化合物。
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3.发明申请
公开(公告)号：WO0192250A3
公开(公告)日：2002-04-25
申请号：PCT/US0117667
申请日：2001-06-01
Applicant: KANTER JAMES , MULLINS JOHN J G , PANDEY ANJALI , SCARBOROUGH ROBERT , COR THERAPEUTICS INC
Inventor： KANTER JAMES , MULLINS JOHN J G , PANDEY ANJALI , SCARBOROUGH ROBERT
IPC: C07D311/22 , C07D311/58
CPC classification number: C07D311/58 , C07D311/22
Abstract: Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors are disclosed. Further disclosed are processes for producing salts such as acid addition salts for such enantiomerically enriched compositions.
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4.发明申请METHODS FOR PRODUCING CHIRAL CHROMONES, CHROMANES, AMINO SUBSTITUTED CHROMANES AND INTERMEDIATES THEREFOR 审中-公开方法生产CHIRAL CHROMONES，CHROMANES，AMINO取代的CHROMANES及其中间体
公开(公告)号：WO0194335A8
公开(公告)日：2003-11-06
申请号：PCT/US0117980
申请日：2001-06-01
Applicant: LILLY CO ELI , COR THERAPEUTICS INC , BRIGGS BARBARA , HANSEN MARVIN , KANTER JAMES , MULLINS JOHN J G , RUHTER GERD , UDODONG UKO , VERRAL DANIEL II , ZMIJEWSKI MILTON JR
Inventor： BRIGGS BARBARA , HANSEN MARVIN , KANTER JAMES , MULLINS JOHN J G , RUHTER GERD , UDODONG UKO , VERRAL DANIEL II , ZMIJEWSKI MILTON JR
IPC: A61K31/353 , A61P7/02 , C07D311/22 , C07D311/24 , C07D311/58 , C07D311/74 , C07D311/70
CPC classification number: C07D311/74 , A61K31/353 , C07D311/22 , C07D311/24 , C07D311/58
Abstract: Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.
Abstract translation: 公开了生产富集至少一种（2R或2S）对映异构体，优选苯并二氢吡喃-2-基羧酸化合物和色满-2-基羧酸酯的色淀组合物的方法步骤和新方法，其是制备血小板聚集抑制剂的中间体， /或本身是有效的血小板聚集抑制剂。 进一步公开的是用于拆分手性中间体或最终产物以提供所需对映异构体的酶法。
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公开(公告)号：WO0194330A8
公开(公告)日：2003-11-06
申请号：PCT/US0117688
申请日：2001-06-01
Applicant: COR THERAPEUTICS INC , KANTER JAMES , MULLINS JOHN J G , SCARBOROUGH ROBERT , WALKER DERRICK , HENSE THOMAS
Inventor： KANTER JAMES , MULLINS JOHN J G , SCARBOROUGH ROBERT , WALKER DERRICK , HENSE THOMAS
IPC: A61P7/00 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/70 , A61K31/35
CPC classification number: C07D311/22 , C07D311/20 , C07D311/58
Abstract: Disclosed are processes for producing chromane compounds, preferably chroman-2-yl acetic acid compounds and 6-amino-chroman-2-yl acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
Abstract translation: 本发明公开了生产色氨酸化合物，优选苯并二氢吡喃-2-基乙酸化合物和6-氨基 - 苯并二氢吡喃-2-基乙酸酯的方法，其为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂。
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Patent Agency Ranking
公开(公告)号：WO0194330A3
公开(公告)日：2002-08-29
申请号：PCT/US0117688
申请日：2001-06-01
Applicant: COR THERAPEUTICS INC , KANTER JAMES , MULLINS JOHN J G , SCARBOROUGH ROBERT , WALKER DERRICK , HENSE THOMAS
Inventor： KANTER JAMES , MULLINS JOHN J G , SCARBOROUGH ROBERT , WALKER DERRICK , HENSE THOMAS
IPC: A61P7/00 , C07D311/20 , C07D311/22 , C07D311/58 , C07D311/70 , A61K31/35
CPC classification number: C07D311/22 , C07D311/20 , C07D311/58
Abstract: Disclosed are processes for producing chromane compounds, preferably chroman-2-yl acetic acid compounds and 6-amino-chroman-2-yl acetic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors.
Abstract translation: 本发明公开了生产色氨酸化合物，优选苯并二氢吡喃-2-基乙酸化合物和6-氨基 - 苯并二氢吡喃-2-基乙酸酯的方法，其为制备血小板聚集抑制剂的中间体和/或本身是有效的血小板聚集抑制剂。
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7.发明申请METHODS FOR PRODUCING CHIRAL CHROMONES, CHROMANES, AMINO SUBSTITUTED CHROMANES AND INTERMEDIATES THEREFOR 审中-公开方法生产CHIRAL CHROMONES，CHROMANES，AMINO取代的CHROMANES及其中间体
公开(公告)号：WO0194335A3
公开(公告)日：2002-08-08
申请号：PCT/US0117980
申请日：2001-06-01
Applicant: LILLY CO ELI , COR THERAPEUTICS INC , BRIGGS BARBARA , HANSEN MARVIN , KANTER JAMES , MULLINS JOHN J G , RUHTER GERD , UDODONG UKO , VERRAL DANIEL II , ZMIJEWSKI MILTON JR
Inventor： BRIGGS BARBARA , HANSEN MARVIN , KANTER JAMES , MULLINS JOHN J G , RUHTER GERD , UDODONG UKO , VERRAL DANIEL II , ZMIJEWSKI MILTON JR
IPC: A61K31/353 , A61P7/02 , C07D311/22 , C07D311/24 , C07D311/58 , C07D311/74 , C07D311/70
CPC classification number: C07D311/74 , A61K31/353 , C07D311/22 , C07D311/24 , C07D311/58
Abstract: Disclosed are process steps and novel processes for producing chromane compositions enriched in at least one (2R or 2S) enantiomer, preferably chroman-2-yl carboxylic acid compounds and chroman-2-yl carboxylic acid esters which are intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are enzymatic processes for resolving chiral intermediates or final products to provide desired enantiomers.
Abstract translation: 公开了生产富集至少一种（2R或2S）对映异构体，优选苯并二氢吡喃-2-基羧酸化合物和色满-2-基羧酸酯的色淀组合物的方法步骤和新方法，其是制备血小板聚集抑制剂的中间体， /或本身是有效的血小板聚集抑制剂。 进一步公开的是用于拆分手性中间体或最终产物以提供所需对映异构体的酶法。
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8.发明申请CHIRAL AND ACHIRAL SYNTHESIS OF 2-ACYL SUBSTITUTED CHROMANES AND THEIR DERIVATIVES 审中-公开2-ACYL取代的色素及其衍生物的合成和丙烯酸合成
公开(公告)号：WO0192249A3
公开(公告)日：2002-04-11
申请号：PCT/US0118016
申请日：2001-06-01
Applicant: COR THERAPEUTICS INC , KANTER JAMES , MARLOWE CHARLES , MULLINS JOHN J G , PANDEY ANJALI , SCARBOROUGH ROBERT , BUTKE GREG , JACOBSEN BARRY , WALKER DERRICK
Inventor： KANTER JAMES , MARLOWE CHARLES , MULLINS JOHN J G , PANDEY ANJALI , SCARBOROUGH ROBERT , BUTKE GREG , JACOBSEN BARRY , WALKER DERRICK
IPC: C07D311/20 , C07D311/22 , C07D311/58 , A61K31/35
CPC classification number: C07D311/58 , C07D311/20 , C07D311/22
Abstract: Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermediates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.
Abstract translation: 公开了制备（2S）或（2R）-4-氧代 - 苯并二氢吡喃-2-基酰基化合物和色满-2-基酰基化合物，其酯或酰胺及其衍生物的方法。 这样的方法可以涉及手性合成或非手性合成，优选与解析程序偶联。 这些化合物，特别是（2S）或（2R）乙酸酯是生产血小板聚集抑制剂和/或本身是有效的血小板聚集抑制剂的有用中间体。 进一步公开的是制备单一（2R）或（2S）对映异构体中间体的这种基本上纯的或增强的组合物的衍生物的方法或从所需的对映异构体制备最终产物或盐的方法。
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公开(公告)号：WO0142198A3
公开(公告)日：2001-12-13
申请号：PCT/US0042819
申请日：2000-12-13
Applicant: COR THERAPEUTICS INC
Inventor： KANTER JAMES , MULLINS JOHN JASON GENTRY , SCARBOROUGH ROBERT
IPC: C07C253/30 , C07C51/265 , C07C201/12 , C07C209/36 , C07C253/00 , C07C255/57 , C07C257/18 , C07C253/08
CPC classification number: C07C253/00 , C07C255/57
Abstract: Novel process steps and novel processes for producing unsubstituted and substituted meta- and para- cyano benzoic acid compounds, as well as salts and derivatives thereof, and intermediates therefor which are useful as intermediates for producing platelet aggregation inhibitors. Further disclosed are processes for producing bicyclic and heterocyclic cyano substituted compounds also having a carboxyl group attached to the same ring structure.
Abstract translation: 用于制备未取代和取代的间位和对 - 氰基苯甲酸化合物的新方法步骤和新方法，以及其盐及其衍生物及其中间体，其可用作制备血小板聚集抑制剂的中间体。 进一步公开的是还具有连接到相同环结构的羧基的双环和杂环氰基取代的化合物的方法。
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公开(公告)号：AU7486600A
公开(公告)日：2001-04-17
申请号：AU7486600
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , JIA ZHAOZHONG JON , HUANG WENRONG , SONG YONGHONG , KANTER JAMES , SCARBOROUGH ROBERT M JR
IPC: C07D231/14 , A61K31/33 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , A61P7/04 , A61P43/00 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/20 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07D231/00
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