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公开(公告)号：WO0047554A3
公开(公告)日：2001-08-09
申请号：PCT/US0003405
申请日：2000-02-11
Applicant: COR THERAPEUTICS INC
Inventor： SONG YONGHONG , ZHU BING-YAN , SCARBOROUGH ROBERT M , CLIZBE LANE , JIA ZHAOZHONG JON , SU TING , TENG WILLY
IPC: C07D295/14 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/341 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/44 , A61K31/4409 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/517 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P31/04 , A61P43/00 , C07C257/18 , C07C311/29 , C07C311/46 , C07C311/51 , C07D213/56 , C07D213/58 , C07D213/70 , C07D213/74 , C07D213/75 , C07D217/22 , C07D231/12 , C07D233/61 , C07D239/42 , C07D239/94 , C07D257/04 , C07D295/16 , C07D307/54 , C07D401/12 , C07D521/00 , A61K31/16 , A61K31/33 , C07D231/56
CPC classification number: C07D231/12 , C07C311/46 , C07C311/51 , C07C2601/10 , C07D217/22 , C07D233/56 , C07D239/94 , C07D249/08 , C07D307/54 , C07D401/12
Abstract: Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted phenyl, naphthyl or bicyclic heterocyclic ring, and the other variables are as defined in the claims, their salts and other derivatives and compositions related thereto having activity against mammalian Factor Xa are disclosed. The coumpounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 其中A是取代或未取代的苯基，萘基或单环杂环的新型式的化合物，D是取代或未取代的苯基或芳族六元杂环，K是取代或未取代的苯基，萘基或双环杂环，以及 其他变量如权利要求中所定义，公开了其与其相关的盐和其它衍生物和组合物具有抗哺乳动物因子Xa的活性。 固体在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：WO0119798A2
公开(公告)日：2001-03-22
申请号：PCT/US0025195
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , JIA ZHAOZHONG JON , HUANG WENRONG , SONG YONGHONG , KANTER JAMES , SCARBOROUGH ROBERT M
IPC: C07D231/14 , A61K31/33 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , A61P7/04 , A61P43/00 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/20 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07D231/00
CPC classification number: C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
Abstract: Compounds of formula A Q D E G J X in which D is a direct link, a substituted or unsubsituted phenyl or naphtyl gourp or a heterocyclic ring system; G is substituted or unsubstituted phenyl or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed, The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Abstract translation: 其中D是直接键，取代或未取代的苯基或萘基金属或杂环系的式A Q D E G J X的化合物; G是取代或未取代的苯基或杂环系; X是取代或未取代的苯基或萘基或杂环系; 并且其它变量如权利要求中所定义，其公开的与其相关的盐和组合物具有抗哺乳动物因子Xa的活性。该化合物在体外或体内可用于预防或治疗凝血障碍。
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公开(公告)号：AU7486600A
公开(公告)日：2001-04-17
申请号：AU7486600
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , JIA ZHAOZHONG JON , HUANG WENRONG , SONG YONGHONG , KANTER JAMES , SCARBOROUGH ROBERT M JR
IPC: C07D231/14 , A61K31/33 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , A61P7/04 , A61P43/00 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/20 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07D231/00
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公开(公告)号：CA2361428A1
公开(公告)日：2000-08-17
申请号：CA2361428
申请日：2000-02-11
Applicant: COR THERAPEUTICS INC
Inventor： TENG WILLY , SU TING , CLIZBE LANE , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M , ZHU BING-YAN , SONG YONGHONG
IPC: C07D295/14 , A61K31/18 , A61K31/192 , A61K31/195 , A61K31/216 , A61K31/341 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4174 , A61K31/44 , A61K31/4409 , A61K31/472 , A61K31/4725 , A61K31/495 , A61K31/505 , A61K31/517 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P31/04 , A61P43/00 , C07C257/18 , C07C311/29 , C07C311/46 , C07C311/51 , C07D213/56 , C07D213/58 , C07D213/70 , C07D213/74 , C07D213/75 , C07D217/22 , C07D231/12 , C07D233/61 , C07D239/42 , C07D239/94 , C07D257/04 , C07D295/16 , C07D307/54 , C07D401/12 , C07D521/00 , A61K31/16 , A61K31/33 , C07D231/56
Abstract: Novel compounds of formula in which A is a substituted or unsubstituted phenyl, naphthyl or monocyclic heterocyclic ring, D is a substituted or unsubstituted phenyl or aromatic six-membered heterocyclic ring, K is a substituted or unsubstituted phenyl, naphthyl or bicyclic heterocyclic ring, and the other variables are as defined in the claims, their salts and other derivatives and compositions related thereto having activity against mammali an Factor Xa are disclosed. The coumpounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：AU781880B2
公开(公告)日：2005-06-16
申请号：AU7486600
申请日：2000-09-15
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , JIA ZHAOZHONG JON , HUANG WENRONG , SONG YONGHONG , KANTER JAMES , SCARBOROUGH ROBERT M
IPC: C07D231/14 , A61K31/33 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , A61P7/04 , A61P43/00 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/20 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07D231/00
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Patent Agency Ranking
公开(公告)号：BR0107282A
公开(公告)日：2004-07-06
申请号：BR0107282
申请日：2001-10-01
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , LI WENHAO , GOLDMAN ERICK A , ZHANG PENGLIE , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M
IPC: C07D241/06 , A61K31/438 , A61K31/495 , A61K31/496 , A61P7/02 , A61P9/00 , A61P9/10 , C07D241/08 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/10 , C07D491/113 , C07D401/12
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公开(公告)号：AU1454602A
公开(公告)日：2002-04-08
申请号：AU1454602
申请日：2001-10-01
Applicant: COR THERAPEUTICS INC
Inventor： ZHANG PENGLIE , LI WENHAO , HUANG WENRONG , WANG LINGYAN , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M JR , ZHU BING-YAN
IPC: A61P7/02 , C07D239/91 , C07D401/04 , C07D401/14 , C07D409/14 , C07D487/04 , A61K31/517 , A61K31/519
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公开(公告)号：AU1128102A
公开(公告)日：2002-04-08
申请号：AU1128102
申请日：2001-10-01
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , HUANG WENRONG , ZHANG PENGLIE , JIA ZHAOZHONG JON , BAO LIANG , WU YANHONG , SCARBOROUGH ROBERT M JR
IPC: A61P7/02 , C07D213/75 , C07D401/12 , C07D401/14 , C07D401/00
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公开(公告)号：AU1128002A
公开(公告)日：2002-04-08
申请号：AU1128002
申请日：2001-10-01
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , SU TING , LI WENHAO , GOLDMAN ERICK A , ZHANG PENGLIE , JIA ZHAOZHONG JON , SCARBOROUGH ROBERT M JR
IPC: C07D241/06 , A61K31/438 , A61K31/495 , A61K31/496 , A61P7/02 , A61P9/00 , A61P9/10 , C07D241/08 , C07D401/10 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/12 , C07D409/14 , C07D491/10 , C07D491/113 , C07D221/00 , C07D317/00 , C07D401/12
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公开(公告)号：NO20021230D0
公开(公告)日：2002-03-12
申请号：NO20021230
申请日：2002-03-12
Applicant: COR THERAPEUTICS INC
Inventor： ZHU BING-YAN , JIA ZHAOZHONG JON , HUANG WENRONG , SONG YONGHONG , KANTER JAMES , SCARBOROUGH ROBERT M
IPC: C07D231/14 , A61K31/33 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P7/02 , A61P7/04 , A61P43/00 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D277/20 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D521/00 , C07D
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