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公开(公告)号：US20240210321A1
公开(公告)日：2024-06-27
申请号：US18567981
申请日：2022-06-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey , Gary Root , Aditya Shirvalkar
IPC: G01N21/64
CPC classification number: G01N21/6486 , G01N21/645 , G01N2021/6417 , G01N2201/1296
Abstract: A method and system of analyzing an ex-vivo tissue sample is provided. The method includes interrogating the tissue sample a plurality of times, each interrogation using at least one excitation light centered on a wavelength distinct from the others, at least one excitation light produces AF emissions from one or more biomolecules associated with the tissue sample, and another is produces diffuse reflectance signals from the tissue sample; b) using a photodetector to detect the AF emissions or diffuse reflectance signals from the tissue sample, producing photodetector signals representative thereof; c) processing the photodetector signals attributable to the AF emissions using a first trained classifier to determine first data sets indicative of biomolecules; d) processing the photodetector signals attributable to the diffuse reflectance signals using a second trained classifier to determine one or more second data sets; and e) determining a type of the tissue sample.
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公开(公告)号：US20220283093A1
公开(公告)日：2022-09-08
申请号：US17688792
申请日：2022-03-07
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Alan Kersey
Abstract: A method and system for classifying a tissue specimen is provided. The method includes: a) interrogating a tissue specimen with a first interrogation light; b) detecting first light from the tissue specimen resulting from the interrogation, wherein the first light includes a first scattered light component and a first fluorescence light component, and producing first signals; c) interrogating the tissue specimen with a second interrogation light at a second excitation wavelength, wherein the first and second excitation wavelengths are within about 2 nm of each other; d) detecting second light from the tissue specimen resulting from the interrogation, wherein the second light includes a second scattered light component and a second fluorescence light component, and producing second signals; e) determining a difference between the first and second lights; f) determining a fluorescence spectrum produced by the interrogation of the tissue specimen; and g) classifying the tissue specimen.
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公开(公告)号：US20220196557A1
公开(公告)日：2022-06-23
申请号：US17601631
申请日：2020-04-06
Applicant: CYTOVERIS INC.
Inventor： Guoan Zheng , Alan Kersey , Rishikesh Pandey , David Fournier
Abstract: An apparatus and method for analyzing a tissue sample to provide depth-selective information includes at least one light source, collection light optics, and a light detector. The light source is configured to produce a light beam having one or more wavelengths of light that cause a tissue sample to produce Raman light signals upon interrogation of the tissue sample. The light beam is oriented to impinge on an exposed surface of the tissue sample at a point of incidence (POI), and oriented so that the light beam enters the tissue sample at an oblique angle relative to the exposed surface of the tissue sample. The collection light optics are configured to collect the Raman light signals emanating from the tissue sample at one or more predetermined lateral distances from the point of incidence. The light detector is configured to receive the Raman light signals from the collection light optics.
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公开(公告)号：US11193827B2
公开(公告)日：2021-12-07
申请号：US16868352
申请日：2020-05-06
Applicant: CytoVeris Inc.
Inventor： Alan Kersey
Abstract: A method and apparatus for determining a level of background fluorescent light produced during photometric interrogation of a sample is provided. The method includes applying an excitation light to a sample using a laser at a plurality linewidths different from one another, the excitation light at each of the plurality of different linewidths applied at an excitation wavelength operable to cause emission of light from the sample, the light emitted from the sample including Raman scattered light and background fluorescent light; detecting light emitted from the tissue sample at each of the plurality of linewidths using a detector and producing light signals representative of the detected light; and determining a level of the background fluorescent using the light signals representative of the detected light for each of the plurality of different linewidths.
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5.发明公开公开(公告)号：US20230346983A1
公开(公告)日：2023-11-02
申请号：US17796536
申请日：2021-02-01
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey , Patrick Curry
CPC classification number: A61K49/001 , A61B5/0075 , A61B5/0091 , A61K41/0052
Abstract: A method and system for determining the presence of a mass of cancerous cells in vivo within a tissue body is provided. The method includes: a) performing an examination of the tissue body using a diagnostic method operable to determine the presence of a suspect tissue mass, and determining a location of the same; b) administering a solution containing “RR-CTEs”, the RR-CTEs configured to target and bind with cancerous cells; c) interrogating the tissue body with a beam of light, wherein the RR-CTEs are configured to produce Raman scattered light upon impingement; d) collecting the Raman scattered light; e) processing the collected Raman scattered light to determine a presence or an absence of the a Raman signature; and f) comparing the determined location of the suspect tissue mass with the determined location of the mass of cancerous cells to determine the presence of the mass of cancerous cells.
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Patent Agency Ranking
6.发明公开公开(公告)号：US20230266170A1
公开(公告)日：2023-08-24
申请号：US18017812
申请日：2021-07-26
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , David Fournier , Rishikesh Pandey , Gary Root
CPC classification number: G01J3/44 , G01J3/12 , G01J3/0208 , G01J3/08 , G01J3/10 , G01J3/0218 , G01J2003/102 , G01J2003/1213 , G01N21/65
Abstract: A system and method for analyzing a sample using Raman spectral light includes a light source, a light detector, a narrow band pass filter and an analyzer. Within the system, excitation light is directed to interrogate the sample. The narrow band pass filter is positioned to receive Raman scattered light produced as a result of the interrogation. The light detector is positioned to receive the Raman scattered light that has passed through the at least one narrow band pass filter. The analyzer contains stored instructions that when executed cause the processor to a) control the light source; and b) process signals produced by the light detector to analyze the sample material, the signals representative of the intensity of the Raman scattered light received by the at least one light detector corresponding to one or more wavenumbers in a high wavenumber region of a Raman signal.
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公开(公告)号：US20230162410A1
公开(公告)日：2023-05-25
申请号：US17992613
申请日：2022-11-22
Applicant: CytoVeris Inc.
Inventor： Rishikesh Pandey , Guoan Zheng , Alan Kersey
CPC classification number: G06T11/001 , G01N21/6486 , G06T3/40 , G06T7/30 , G06T2207/10064 , G06T2207/10152 , G06T2207/20016 , G06T2207/30024 , G06T2210/41
Abstract: A system for and method of producing a virtually stained histological tissue sample is provided that includes: a) acquiring a plurality of autofluorescence (AF) images of an unstained tissue sample, each AF image of the plurality of images produced by interrogating the tissue sample at an AF excitation wavelength configured to produce AF emissions at an AF emission wavelength, wherein the AF excitation wavelength and the AF emission wavelength used to produce each AF image of the plurality of AF images is different from the AF excitation wavelength and the AF emission wavelength used to produce the other AF images of the plurality of AF images; b) virtually staining the tissue sample using the plurality of AF images using artificial intelligence to represent a coloration of at least one histological stain; and c) producing a virtually stained histological tissue sample from the virtual staining.
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8.发明申请公开(公告)号：US20220079450A1
公开(公告)日：2022-03-17
申请号：US17478513
申请日：2021-09-17
Applicant: CytoVeris Inc.
Inventor： David Fournier , Rishikesh Pandey , Michael A. Sapack , Patrick M. Curry , Alan Kersey
IPC: A61B5/00
Abstract: A system and method for determining the presence of cancerous tissue within a tissue cavity is provided. The system includes one or more excitation light sources, a photodetector, a probe, and a system controller. The probe includes an optically transparent probe body configured to fit within the tissue cavity. The system controller is in communication with the excitation light sources, the photodetector, and a memory storing instructions. The instructions when executed cause the system controller to a) control the excitation light sources to produce excitation light beams within the probe body, the excitation light beams operable to produce a response of the tissue to the interrogation and control the photodetector to detect the response and produce signals representative thereof; and b) produce information indicative of a presence of the cancerous tissue using the signals representative of the response.
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公开(公告)号：US20220057263A1
公开(公告)日：2022-02-24
申请号：US17408976
申请日：2021-08-23
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey , David Fournier , Gary Root
Abstract: A system for processing Raman scattering light from a sample is provided. The system includes a source, a digital mirror device (DMD), a detector, and an analyzer. The DMD is configured to reflect Raman scattering light and includes micromirrors selectively controllable between ON and OFF states. The detector is configured to detect Raman scattering light and to produce signals representative of the Raman scattering light. The analyzer is in communication with the light source, the DMD, the detector, and a memory storing instructions, which instructions when executed cause the processor to: a) control the light source to produce a beam of light for interrogating the sample; b) control the DMD to place in an ON or OFF state based on one or more known spectral shapes stored in the memory; and c) process the Raman scattering light reflected by the micromirrors in the ON state.
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公开(公告)号：US20250082205A1
公开(公告)日：2025-03-13
申请号：US18882678
申请日：2024-09-11
Applicant: CytoVeris Inc.
Inventor： Alan Kersey , Rishikesh Pandey
IPC: A61B5/00
Abstract: A method and system for analyzing a tissue, the method includes: administering a fluorescent agent to the tissue; producing a first excitation light configured to produce an autofluorescence emission from a biomolecule present within the tissue, and a diffuse reflectance signal from the tissue; producing a second excitation light configured to produce a fluorescence emission from the fluorescent agent administered to the tissue; using a photodetector to detect the autofluorescence emissions, the diffuse reflectance signals and produce first signals representative of the autofluorescence emission and the diffuse reflectance; using the photodetector to detect the fluorescence emissions and produce second signals representative of the fluorescence emission; producing a first image using the first signals; producing a second image using the second signals; and analyzing the tissue using the first image and the second image to identify the presence of diseased tissue within the tissue.
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