公开(公告)号：ES2000283A6

公开(公告)日：1988-02-01

申请号：ES8600712

申请日：1986-07-30

Applicant: DEGUSSA

Inventor： ENGEL JURGEN ,  KUTSCHER BRNHARD ,  OEPEN GERHARD ,  NIEBCH GEORG ,  METZENAUER PETER

IPC: A61K31/135 ,  A61K31/24 ,  C07C20060101 ,  C07C97/10

Abstract: SE DESCRIBE UN PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS ACTIVOS SOBRE EL CORAZON DE FORMULA ****FORMULA-DIBUJO**** EN DONDE R1 ES HIDROGENO, UN GRUPO HIDROXI O UN GRUPO ALCANOILOXI C2-C13, R2 ES UN GRUPO HIDROXI O UN GRUPO ALCANOILOXI C2-C13, Y R3 ES HIDROGENO, UN GRUPO HIDROXI, UN GRUPO ALCANOILOXI C2-C13 O UN GRUPO BENCILOXI, Y SUS SALES POR ADICION DE ACIDOS.

公开(公告)号：MX154885A

公开(公告)日：1987-12-28

申请号：MX749982

申请日：1982-06-10

Applicant: DEGUSSA

Inventor： ENGEL JURGEN ,  OEPEN GERHARD

IPC: A61K31/135 ,  C07C91/14

公开(公告)号：AU564272B2

公开(公告)日：1987-08-06

申请号：AU3352784

申请日：1984-09-26

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  ENGEL JURGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: C07C45/63 ,  C07C45/71 ,  C07C217/62 ,  A61K31/135 ,  C07C91/34 ,  C07C93/14

公开(公告)号：AU561450B2

公开(公告)日：1987-05-07

申请号：AU2058283

申请日：1983-10-26

Applicant: DEGUSSA

Inventor： BEBENBURG WALTER VON ,  HEESE JOACHIM ,  ENGEL JURGEN ,  THIELE KURT

IPC: C07D213/74 ,  A61K31/44 ,  A61P25/08 ,  C07D213/75

Abstract: Compounds of the formula I where R is a C1-C4 alkyl group, a C1-C4 alkoxy group, a phenoxy group or a phenyl-C1-C2-alkoxy group, R1 is hydrogen or a C1-C4-alkyl group and R5 is hydrogen or a C1-C4-alkyl group and the groups R2, R3, and R4 are the same or different and are hydrogen, halogen atoms, C1-C4 alkyl groups, C1-C4-alkylcarbonyl group, the aminosulfonyl group, the trifluoromethyl group and their acid addition salts are effective as antiepileptics.

公开(公告)号：AU3699684A

公开(公告)日：1985-07-04

申请号：AU3699684

申请日：1984-12-20

Applicant: DEGUSSA

Inventor： SCHEFFLER GERHARD ,  NICKEL BERND ,  THIEMER KLAUS ,  ENGEL JURGEN ,  JAKOVLEV VLADIMIR

IPC: C07D401/12 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/46 ,  A61K31/55 ,  A61P25/04 ,  A61P29/00 ,  C07D211/54 ,  C07D213/643 ,  C07D213/70 ,  C07D213/71 ,  C07D213/89 ,  C07D243/00 ,  C07D317/00 ,  C07D405/12 ,  C07D405/14 ,  C07D451/02 ,  C07D451/06 ,  C07D453/02

Abstract: There are disclosed pyridine-2-ethers and pyridine-2-thioethers having a nitrogen-containing cycloaliphatic ring corresponding to the formula I the pyridine-N-oxides and/or amine oxides thereof and the pharmaceutically acceptable salts thereof. The compounds show analgesic activity.

公开(公告)号：AU2605784A

公开(公告)日：1984-09-27

申请号：AU2605784

申请日：1984-03-23

Applicant: DEGUSSA

Inventor： OEPEN GERHARD ,  ENGEL JURGEN ,  JAKOVLEV VLADIMIR ,  THIEMER KLAUS

IPC: C07D295/18 ,  A61K31/495 ,  A61K31/496 ,  A61P25/04 ,  A61P29/00 ,  C07D213/72 ,  C07D213/74 ,  C07D239/42 ,  C07D241/20 ,  C07D295/185

Abstract: There are prepared new pharmacologically active compounds of the formula: I In formula I R1 is a phenyl radical, pyridyl radical, a pyrimidyl group, or pyrazinyl radical, or a phenyl radical, pyridiyl radical, pyrimidyl radical, or pyrazinyl radical substituted by the radicals R3 and R4 which are the same or different and are hydrogen, fluorine, chlorine, bromine, trifluoromethyl, hydroxyl, C1-C6-alkyl groups C1-C6-alkoxy groups, C3-C6-alkenyloxy groups, C3-C6-cycloalkyloxy groups, phenyl-C1-C4-alkoxy groups, C1-C6-alkylmercapto groups, the nitro group, the amino group, C1-C6-dialkylamino groups, C2-C6-alkanoyl groups, C2-C6-alkanoylamino groups, or C2-C6-alkanoyloxy groups and R2 is the adamantyl group, the 3,3-dimethyl-bicyclo[2.2.1]hept-2-yl radical, a saturated C3-C16-cycloalkenyl radical and alk is a straight or branched C1-C6 alkyl chain.

公开(公告)号：AU4709479A

公开(公告)日：1979-11-22

申请号：AU4709479

申请日：1979-05-16

Applicant: DEGUSSA

Inventor： ENGEL JURGEN ,  KLEEMANN AXEL ,  POSSELT KLAUS ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/135 ,  A61K20060101 ,  A61K31/13 ,  A61K31/137 ,  A61K31/43 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P29/00 ,  C07C20060101 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C213/08 ,  C07C215/30 ,  C07C215/60 ,  C07C221/00 ,  C07C225/06 ,  C07C225/10 ,  C07C225/14 ,  C07C97/10

Abstract: There are prepared compounds of the formula: wherein X is the group >C=O or >CH(OH), Y is the group R2 is hydrogen or C1 to C6 alkyl, R3 is hydrogen or a hydroxy group and R1 is the adamantyl group or a saturated or single unsaturated C3 to C16 cycloalkyl group where the C3 to C16 cycloalkyl group can be substituted by a C1-C4 alkyl group or a halogen atom and their salts. The compounds are useful in dilating the peripheral blood vessels and in lowering blood pressure.

公开(公告)号：CS249503B2

公开(公告)日：1987-03-12

申请号：CS214178

申请日：1978-04-03

Applicant: DEGUSSA

Inventor： KLEEMANN AXEL ,  JAKOVLEV VLADIMIR ,  THIEMER KLAUS ,  ENGEL JURGEN

IPC: C07D295/08 ,  A61K31/495 ,  A61K31/496 ,  A61P25/18 ,  A61P25/20 ,  C07D213/74 ,  C07D213/80 ,  C07D295/033 ,  C07D295/088 ,  C07D295/092 ,  C07D295/135 ,  C07D303/24 ,  C07D307/68 ,  C07D333/38

公开(公告)号：AU6070186A

公开(公告)日：1987-02-05

申请号：AU6070186

申请日：1986-07-30

Applicant: DEGUSSA

Inventor： ENGEL JURGEN ,  KUTSCHER BERNHARD ,  OEPEN GERHARD ,  NIEBCH GEORG ,  METZENAUER PETER

IPC: A61K31/135 ,  A61K31/24 ,  C07C20060101 ,  C07C97/065

公开(公告)号：MC1651A1

公开(公告)日：1986-04-07

申请号：MC1765

申请日：1985-05-03

Applicant: DEGUSSA

Inventor： HETTCHE HELMUT ,  EMIG PETER ,  ENGEL JURGEN

IPC: A61K31/19 ,  A61K31/191 ,  A61K31/44 ,  A61P25/04 ,  A61P29/00 ,  C07C51/00 ,  C07C59/105 ,  C07C67/00 ,  C07D213/75 ,  C07D ,  A61K

Abstract: There is disclosed 2-amino-3-ethoxycarbonylamino-6-(p-fluoro-benzylamino)-pyridine gluconate, process for its production and pharmaceutical preparations which contain this material.