公开(公告)号：US3896119A

公开(公告)日：1975-07-22

申请号：US29279872

申请日：1972-09-27

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ

IPC: C07D473/08 ,  C07D87/34

CPC classification number: Y10S514/826

Abstract: Compound are prepared having the formula:

where R1 is hydrogen or methyl, R2 and R3 are hydrogen, methyl, hydroxy, or hydroxymethyl, R7 is hydrogen or methyl and R4 is alkyl of 1 to 6 carbon atoms, phenylalkyl of 7 to 12 carbon atoms or -NR5R6 where R5 and R6 individually are hydrogen or alkyl of 1 to 6 carbon atoms or R5 and R6 together with the nitrogen atom form a 5 to 7 membered ring which can have an additional oxygen, nitrogen or sulfur atom and also can contain 0 to 2 alkyl substituents with 1 to 4 carbon atoms or salts thereof. The compounds have outstanding broncholytic activity.

公开(公告)号：AU564272B2

公开(公告)日：1987-08-06

申请号：AU3352784

申请日：1984-09-26

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  ENGEL JURGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: C07C45/63 ,  C07C45/71 ,  C07C217/62 ,  A61K31/135 ,  C07C91/34 ,  C07C93/14

公开(公告)号：CA1116173A

公开(公告)日：1982-01-12

申请号：CA335022

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/155 ,  A61K31/403 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C129/12 ,  C07D209/20

Abstract: Compounds corresponding to the formula (I) are disclosed, wherein Alk represents a C2-C5-alkylene group which may be substituted by a hydroxy group and Ar represents unsubstituted phenyl, naphthyl or indolyl radical or a phenyl, naphthyl or indolyl radical substituted one or more times by a Cl-C6-alkyl group, a C2-C6-alkenyl group, a Cl-C6-alkoxy group, a C2-C6-alkenoxy group, or a halogen atom and pharmaceutically acceptable acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyi guanidines block the .beta.-receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：NO792874L

公开(公告)日：1980-03-07

申请号：NO792874

申请日：1979-09-05

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  KLEEMANN AXEL ,  STROMAN FRITZ ,  THIEMER KLAUS

IPC: A61K31/403 ,  A61K31/155 ,  A61K31/405 ,  A61P25/02 ,  A61P27/02 ,  C07C67/00 ,  C07C239/00 ,  C07C279/04 ,  C07C279/12 ,  C07D209/08 ,  C07D209/43 ,  C07D209/86 ,  C07D209/88 ,  C07C

Abstract: Compounds corresponding to the formula I are disclosed, wherein Alk represents a C2-C5-alkylene groups optionally substituted by a hydroxy group and Ar represent an optionally substituted phenyl, naphthyl, tetrahydronaphthyl, indanyl or indenyl radical or a monocyclic or condensed bicyclic or tricyclic heterocyclic radical which is optionally substituted, the heterocyclic radical consisting of individual rings having 5 or 6 members and optionally containing from 1 to 4 hetero atoms, and the acid addition salts thereof. A process for producing these compounds is also disclosed. These substituted aminoalkyl guanidines block the beta -receptors of the adrenergic nerve system, and also reduce blood pressure.

公开(公告)号：CS194741B2

公开(公告)日：1979-12-31

申请号：CS108976

申请日：1976-02-19

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  AURICH RUDOLF ,  HABERSANG SILKE

IPC: C07D451/10 ,  A61K31/439 ,  A61P11/08 ,  C07D451/00 ,  C07D473/08 ,  C07D519/00

Abstract: There are prepared quaternary xanthinylalkylnortropine derivatives of the general formula I I where T represents a theophyllinyl-7 radical or a theobrominyl-(1)-radical, Alk is a straight or branched chain alkylene group having 2 to 10 carbon atoms or such a group substituted by a hydroxyl group, R is an alkyl group of 1 to 4 carbon atoms and A(-) is an equivalent to an anion of a physiologically compatible mono- or polyvalent acid. The compounds are useful as medicines having a spasmolytic activity.

公开(公告)号：CA1229622A

公开(公告)日：1987-11-24

申请号：CA464296

申请日：1984-09-28

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  ENGEL JUERGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: C07C45/63 ,  C07C45/71 ,  C07C217/62 ,  C07C91/34

Abstract: There are prepared new compounds of the formula: I where R1 is a C1-C4-alkyl group, R2 is a phenyl group or a phenyl group substituted by a halogen atom, a hydroxy group, a C1-C6 alkyl group or a C1C6-alkoxy group, or a cycloalkyl group having 5 to 6 ring carbon atoms or cycloalkyl group having 5 to 6 ring carbon atoms substituted by a C1-C6-alkyl group or a C1-C6-alkoxy group and Alk is an alkylene group having 3 or 4 carbon atoms and their pharmaceutically acceptable acid addition salts which have a positive inotropic action.

公开(公告)号：ZA847681B

公开(公告)日：1985-11-27

申请号：ZA847681

申请日：1984-09-28

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  ENGEL JUERGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: A61K31/135 ,  A61K20060101 ,  A61P9/00 ,  C07C20060101 ,  C07C45/63 ,  C07C45/71 ,  C07C67/00 ,  C07C213/00 ,  C07C213/02 ,  C07C215/60 ,  C07C217/62 ,  C07C ,  A61K

公开(公告)号：FI843827L

公开(公告)日：1985-03-30

申请号：FI843827

申请日：1984-09-28

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  ENGEL JUERGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: C07C45/63 ,  C07C45/71 ,  C07C217/62 ,  C07C

公开(公告)号：DD220304A5

公开(公告)日：1985-03-27

申请号：DD26775784

申请日：1984-09-28

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  ENGEL JUERGEN ,  OEPEN GERHARD ,  STROMAN FRITZ ,  THIEMER KLAUS ,  METZENAUER PETER

IPC: C07C45/63 ,  C07C45/71 ,  C07C217/62 ,  C07C91/16 ,  C07C91/22

公开(公告)号：FI780137A

公开(公告)日：1978-07-18

申请号：FI780137

申请日：1978-01-16

Applicant: DEGUSSA

Inventor： KLINGLER KARL-HEINZ ,  BICKEL ERICH

IPC: C07D473/08 ,  C07D

Abstract: Basic substituted alkyl theophylline derivatives of the formula (I) in which Alk is a straight or branched chain alkylene group with 2 to 4 carbon atoms and R is hydrogen or a methyl group are produced by catalytic hydrogenation of compounds of the formula (II) where the phenolic hydroxyl groups and/or the secondary basic nitrogen atom can contain protective groups using as the solvent a compound of the formula (III) where R', R'' and R''' are the same or different and are alkyl groups of 1 to 2 carbon atoms and R' together with R''' can also be an alkylene bridge with 3 to 4 carbon atoms and in a given case the protective groups present are split off.