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    ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE
    1.
    发明申请
    ALDEHYDE DEHYDROGENASE VARIANTS AND METHODS OF USE 审中-公开

    公开(公告)号：WO2018183664A1

    公开(公告)日：2018-10-04

    申请号：PCT/US2018/025122

    申请日：2018-03-29

    Applicant: GENOMATICA, INC.

    Inventor： HOFF, Kevin ,  TRACEWELL, Cara, Ann ,  CHAN, Kui ,  SHAH, Amit ,  WARNER, Joseph ,  NOBLE, Michael

    IPC: C12N9/02

    Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3 -butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.

    3-HYDROXYBUTYRYL-COA DEHYDROGENASE VARIANTS AND METHODS OF USE
    2.
    发明申请
    3-HYDROXYBUTYRYL-COA DEHYDROGENASE VARIANTS AND METHODS OF USE 审中-公开

    公开(公告)号：WO2018183640A1

    公开(公告)日：2018-10-04

    申请号：PCT/US2018/025086

    申请日：2018-03-29

    Applicant: GENOMATICA, INC.

    Inventor： HOFF, Kevin ,  TRACEWELL, Cara, Ann ,  CHAN, Kui ,  KUCHINSKAS, Michael ,  NAGARAJAN, Harish

    IPC: C12N9/04 ,  C12P7/42

    Abstract: The present disclosure provides thiolases and polypeptide variants of 3-hydroxybutyryl- CoA dehydrogenase, nucleic acids encoding the same, vectors comprising the nucleic acids, and cells comprising the polypeptide variants and/or thiolase, the nucleic acids, and/or the vectors. The present disclosure also provides methods of making and using the same, including methods for culturing cells, and for the production of various products, including 3-hydroxybutyryl-CoA (3-HB-CoA), 3-hydroxybutyraldehyde (3-HBal), 3-hydroxybutyrate (3-HB), 1,3-butanediol (1,3-BDO), and esters and amides thereof, and products made from any of these.

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