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公开(公告)号：WO2022155554A1
公开(公告)日：2022-07-21
申请号：PCT/US2022/012644
申请日：2022-01-15
Applicant: GENOMATICA, INC.
Inventor： NAGARAJAN, Harish , YANG, Yae, Hoon , KHODAYARI, Ali , BACHAN, Shawn , GHATAK, Sankha , EAKLEY, Nicholas , SHAH, Amit , SHAH, Jinel , ZHANG, Bo
Abstract: Disclosed are biosynthetic methods and engineered microorganisms that enhance or improve the biosynthesis of 6-aminocaproate, hexamethylenediamine, caproic acid, caprolactone, or caprolactam. The engineered microorganisms are modified to include, for example, upredulated and/or exogenous transporters for 6-aminocaproate, deletions and/or downregulated importers for 6-aminocaproate, upregulated and/or exogenous glutamate dehydrogenase, and/or deletions and/or downregulation of res A and/or cpsBG. Other engineered microorganisms may have disruptions of endogenous transporters for 6- aminocaproate.
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公开(公告)号：WO2020068900A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/052829
申请日：2019-09-25
Applicant: GENOMATICA, INC.
Inventor： SHAH, Amit , WARNER, Joseph
IPC: C12N9/02
Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3-butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.
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公开(公告)号：WO2018183664A1
公开(公告)日：2018-10-04
申请号：PCT/US2018/025122
申请日：2018-03-29
Applicant: GENOMATICA, INC.
Inventor： HOFF, Kevin , TRACEWELL, Cara, Ann , CHAN, Kui , SHAH, Amit , WARNER, Joseph , NOBLE, Michael
IPC: C12N9/02
Abstract: The invention provides polypeptides and encoding nucleic acids of aldehyde dehydrogenase variants. The invention also provides cells expressing aldehyde dehydrogenase variants. The invention further provides methods for producing 3-hydroxybutyraldehyde (3-HBal) and/or 1,3 -butanediol (1,3-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells. The invention additional provides methods for producing 4-hydroxybutyraldehyde (4-HBal) and/or 1,4-butanediol (1,4-BDO), or an ester or amide thereof, comprising culturing cells expressing an aldehyde dehydrogenase variant or using lysates of such cells.
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Patent Agency Ranking
公开(公告)号：EP4277976A1
公开(公告)日：2023-11-22
申请号：EP22740197.3
申请日：2022-01-15
Applicant: Genomatica, Inc.
Inventor： NAGARAJAN, Harish , YANG, Tae, Hoon , KHODAYARI, Ali , BACHAN, Shawn , GHATAK, Sankha , EAKLEY, Nicholas , SHAH, Amit , SHAH, Jinel , ZHANG, Bo
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公开(公告)号：EP3856896A1
公开(公告)日：2021-08-04
申请号：EP19783867.5
申请日：2019-09-25
Applicant: Genomatica, Inc.
Inventor： SHAH, Amit , WARNER, Joseph
IPC: C12N9/02
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6.发明公开MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS 审中-公开用于生产4-羟基丁酸酯，1,4-丁二醇及相关化合物的微生物和方法
公开(公告)号：EP2989113A2
公开(公告)日：2016-03-02
申请号：EP14788673.3
申请日：2014-04-25
Applicant: Genomatica, Inc.
Inventor： PHARKYA, Priti , BURGARD, Anthony P. , VAN DIEN, Stephen J. , OSTERHOUT, Robin E. , BURK, Mark J. , TRAWICK, John D. , KUCHINSKAS, Michael P. , STEER, Brian , ANDRAE, Stefan , SHAH, Amit
CPC classification number: C12P7/18 , C07C31/207 , C07C47/19 , C07C211/09 , C07D307/33 , C12N1/20 , C12N9/0006 , C12N9/13 , C12N15/52 , C12P7/24 , C12P7/42 , C12P7/62 , C12P13/001 , C12P13/005 , C12P17/04 , C12P19/32 , C12Y208/03
Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.
Abstract translation: 本发明提供具有4-羟基丁酸酯，γ-丁内酯，1,4-丁二醇，4-羟基丁醛，4-羟基丁酰-CoA和/或腐胺途径并且能够产生4-羟基丁酸酯的非天然存在的微生物，其中 微生物生物体包含一种或多种遗传修饰。 本发明另外提供了使用微生物生产4-羟基丁酸酯，γ-丁内酯，1,4-丁二醇，4-羟基丁醛，4-羟基丁酰-CoA和/或腐胺或相关产物的方法。
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7.发明公开
公开(公告)号：EP4414451A2
公开(公告)日：2024-08-14
申请号：EP24169292.0
申请日：2014-04-25
Applicant: Genomatica, Inc.
Inventor： PHARKYA, Priti , BURGARD, Anthony P. , VAN DIEN, Stephen J. , OSTERHOUT, Robin E. , BURK, Mark J. , TRAWICK, John D. , KUCHINSKAS, Michael P. , STEER, Brian , ANDRAE, Stefan , SHAH, Amit
IPC: C12N15/00
CPC classification number: C12P7/24 , C12P7/62 , C12P17/04 , C12N15/52 , C12P7/42 , C12P13/005 , C12P7/18 , C12P13/001 , C07D307/33 , C12N9/13 , C12Y208/03
Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.
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公开(公告)号：EP3601546A1
公开(公告)日：2020-02-05
申请号：EP18718343.9
申请日：2018-03-29
Applicant: Genomatica, Inc.
Inventor： HOFF, Kevin , TRACEWELL, Cara, Ann , CHAN, Kui , SHAH, Amit , WARNER, Joseph , NOBLE, Michael
IPC: C12N9/02
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