公开(公告)号：WO2022155554A1

公开(公告)日：2022-07-21

申请号：PCT/US2022/012644

申请日：2022-01-15

Applicant: GENOMATICA, INC.

Inventor： NAGARAJAN, Harish ,  YANG, Yae, Hoon ,  KHODAYARI, Ali ,  BACHAN, Shawn ,  GHATAK, Sankha ,  EAKLEY, Nicholas ,  SHAH, Amit ,  SHAH, Jinel ,  ZHANG, Bo

IPC: C12N1/21 ,  C12N15/52 ,  C12P7/18

Abstract: Disclosed are biosynthetic methods and engineered microorganisms that enhance or improve the biosynthesis of 6-aminocaproate, hexamethylenediamine, caproic acid, caprolactone, or caprolactam. The engineered microorganisms are modified to include, for example, upredulated and/or exogenous transporters for 6-aminocaproate, deletions and/or downregulated importers for 6-aminocaproate, upregulated and/or exogenous glutamate dehydrogenase, and/or deletions and/or downregulation of res A and/or cpsBG. Other engineered microorganisms may have disruptions of endogenous transporters for 6- aminocaproate.

公开(公告)号：WO2016164586A1

公开(公告)日：2016-10-13

申请号：PCT/US2016/026445

申请日：2016-04-07

Applicant: GENOMATICA, INC.

Inventor： CULLER, Stephanie J. ,  EAKLEY, Nicholas ,  HOFF, Kevin Gregory ,  OSTERHOUT, Robin E. ,  PHARKYA, Priti ,  RALPH, Erik C. ,  VAN DIEN, Stephen

IPC: C12P7/04

CPC classification number: C12P5/026 ,  C12N9/0006 ,  C12N9/001 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10

Abstract: Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic modifications in alcohol dehydrogenase, alkene reductase or both enzymatic activities. By such genetic modifications, a crotyl alcohol production pathway is provided or improved.

Abstract translation: 公开了增强或改善巴豆醇生产的方法和工程微生物。 工程微生物包括醇脱氢酶，烯烃还原酶或两种酶活性的遗传修饰。 通过这样的遗传修饰，提供或改进了巴布醇生产途径。

公开(公告)号：EP3280808B1

公开(公告)日：2020-09-16

申请号：EP16718940.6

申请日：2016-04-07

Applicant: Genomatica, Inc.

Inventor： CULLER, Stephanie J. ,  EAKLEY, Nicholas ,  HOFF, Kevin Gregory ,  OSTERHOUT, Robin E. ,  PHARKYA, Priti ,  RALPH, Erik C. ,  VAN DIEN, Stephen

IPC: C12P7/04 ,  C12N1/20 ,  C12N9/02

公开(公告)号：EP4277976A1

公开(公告)日：2023-11-22

申请号：EP22740197.3

申请日：2022-01-15

Applicant: Genomatica, Inc.

Inventor： NAGARAJAN, Harish ,  YANG, Tae, Hoon ,  KHODAYARI, Ali ,  BACHAN, Shawn ,  GHATAK, Sankha ,  EAKLEY, Nicholas ,  SHAH, Amit ,  SHAH, Jinel ,  ZHANG, Bo

IPC: C12N1/21 ,  C12N15/52 ,  C12P7/18

公开(公告)号：EP3280808A1

公开(公告)日：2018-02-14

申请号：EP16718940.6

申请日：2016-04-07

Applicant: Genomatica, Inc.

Inventor： CULLER, Stephanie J. ,  EAKLEY, Nicholas ,  HOFF, Kevin Gregory ,  OSTERHOUT, Robin E. ,  PHARKYA, Priti ,  RALPH, Erik C. ,  VAN DIEN, Stephen

IPC: C12P7/04

Abstract: Disclosed are methods and engineered microorganisms that enhance or improve the production of crotyl alcohol. The engineered microorganisms include genetic modifications in alcohol dehydrogenase, alkene reductase or both enzymatic activities. By such genetic modifications, a crotyl alcohol production pathway is provided or improved.