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Patent Agency Ranking
公开(公告)号：WO2020006058A3
公开(公告)日：2020-01-02
申请号：PCT/US2019/039207
申请日：2019-06-26
Applicant: GENOMATICA, INC.
Inventor： NAGARAJAN, Harish , YANG, Tae, Hoon , KHODAYARI, Ali
IPC: C12P5/00 , C12P5/02 , C12P7/04 , C12P7/16 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/64 , C12P13/00 , C12N9/02 , C12N9/16 , C12N9/88 , C12N9/90
Abstract: Described herein are engineered cells including ones having synthetic methylotrophy which include an NADH-dependent enzyme capable of converting G3P to 3PG (e.g.,6. methanolicus gapN ) and/ or fructose-1, 6-bisphosphatase, along with hexulose-6-phosphate synthase, 6-phospho-3-hexuloisomerase, a phosphoketolase, or a combination thereof. Engineered cells of the disclosure beneficially maintain adequate pool sizes of phosphorylated C3 and/or C4 compounds, and/or provide increased levels of NADPH. As such, the modifications allow for the generation of C6 compounds from Cl (e.g. a methanol feedstod) and C5 compounds, the regeneration of C5 compounds from C6 compounds by carbon rearrangement, and an improved balance between regeneration of C5 compounds and lower glycolysis.
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公开(公告)号：WO2022155554A1
公开(公告)日：2022-07-21
申请号：PCT/US2022/012644
申请日：2022-01-15
Applicant: GENOMATICA, INC.
Inventor： NAGARAJAN, Harish , YANG, Yae, Hoon , KHODAYARI, Ali , BACHAN, Shawn , GHATAK, Sankha , EAKLEY, Nicholas , SHAH, Amit , SHAH, Jinel , ZHANG, Bo
Abstract: Disclosed are biosynthetic methods and engineered microorganisms that enhance or improve the biosynthesis of 6-aminocaproate, hexamethylenediamine, caproic acid, caprolactone, or caprolactam. The engineered microorganisms are modified to include, for example, upredulated and/or exogenous transporters for 6-aminocaproate, deletions and/or downregulated importers for 6-aminocaproate, upregulated and/or exogenous glutamate dehydrogenase, and/or deletions and/or downregulation of res A and/or cpsBG. Other engineered microorganisms may have disruptions of endogenous transporters for 6- aminocaproate.
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公开(公告)号：WO2020006058A2
公开(公告)日：2020-01-02
申请号：PCT/US2019/039207
申请日：2019-06-26
Applicant: GENOMATICA, INC.
Inventor： NAGARAJAN, Harish , YANG, Tae, Hoon , KHODAYARI, Ali
IPC: C12P5/00 , C12P5/02 , C12P7/04 , C12P7/16 , C12P7/18 , C12P7/24 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/64 , C12P13/00 , C12N9/02 , C12N9/16 , C12N9/88 , C12N9/90
Abstract: Described herein are engineered cells including ones having synthetic methylotrophy which include an NADH-dependent enzyme capable of converting G3P to 3PG (e.g., B. methanolicus gapN) and/or fructose-1,6-bisphosphatase, along with hexulose-6-phosphate synthase, 6-phospho-3-hexuloisomerase, a phosphoketolase, or a combination thereof. Engineered cells of the disclosure beneficially maintain adequate pool sizes of phosphorylated C3 and/or C4 compounds, and/or provide increased levels of NADPH. As such, the modifications allow for the generation of C6 compounds from C1 (e.g., a methanol feedstod) and C5 compounds, the regeneration of C5 compounds from C6 compounds by carbon rearrangement, and an improved balance between regeneration of C5 compounds and lower glycolysis. In turn, this allows the engineered microorganism to generate sufficient quantities of metabolic precursors (e.g., acetyl-CoA) which can be used in a bioproduct pathway, and the engineered cells can include further modifications to those pathway enzymes allowing for production of a desired bioproduct.
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公开(公告)号：EP4277976A1
公开(公告)日：2023-11-22
申请号：EP22740197.3
申请日：2022-01-15
Applicant: Genomatica, Inc.
Inventor： NAGARAJAN, Harish , YANG, Tae, Hoon , KHODAYARI, Ali , BACHAN, Shawn , GHATAK, Sankha , EAKLEY, Nicholas , SHAH, Amit , SHAH, Jinel , ZHANG, Bo
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公开(公告)号：EP3814515A2
公开(公告)日：2021-05-05
申请号：EP19740662.2
申请日：2019-06-26
Applicant: Genomatica, Inc.
Inventor： NAGARAJAN, Harish , YANG, Tae, Hoon , KHODAYARI, Ali
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