公开(公告)号：JP2007176893A

公开(公告)日：2007-07-12

申请号：JP2005379805

申请日：2005-12-28

Applicant: Kao Corp ,  花王株式会社

Inventor： SASA TOMOAKI ,  UENO KATSUYA ,  IHARA TAKESHI ,  MIZUSHIMA YOUSEN

IPC: C07H15/04

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing an alkylgalactoside in high yield while suppressing production of highly condensed products when producing the alkylgalactoside and to provide an alkylgalactoside composition scarcely having highly condensed product content.
SOLUTION: The method for producing the alkylgalactoside comprises (1) glycosidating galactose by using a higher aliphatic alcohol or (2) glycosidating galactose by using a lower aliphatic alcohol and then carrying out acetal exchange reaction of the glycosidated material with a higher aliphatic alcohol. In the production method, the higher aliphatic alcohol is used in an amount of 8-25 times by mol based on galactose. The alkylgalactoside composition scarcely having highly condensed product content is obtained by the above method.
COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 待解决的问题：提供一种在制备烷基半乳糖苷时抑制高浓缩产物的产生而产生高产率的烷基半乳糖苷的方法，并提供几乎不具有高浓缩产物含量的烷基半乳糖苷组合物。 解决方案：制备烷基半乳糖苷的方法包括：（1）通过使用高级脂肪醇糖化糖苷，或（2）通过使用低级脂肪醇糖化半乳糖，然后进行糖基化物质与高级脂肪族的缩醛交换反应 醇。 在制造方法中，高级脂肪醇的用量相对于半乳糖为8〜25倍摩尔。 通过上述方法获得几乎不具有高浓缩产物含量的烷基半乳糖苷组合物。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2006241064A

公开(公告)日：2006-09-14

申请号：JP2005058634

申请日：2005-03-03

Applicant: Kao Corp ,  花王株式会社

Inventor： UENO KATSUYA ,  MIZUSHIMA YOUSEN ,  KUBOTA HIROMI ,  ENDO KATSUMI

IPC: A01N43/16 ,  A61K8/00 ,  A61K8/60 ,  A61K31/7028 ,  A61P35/00

CPC classification number: A01N43/16 ,  A01N37/40 ,  A01N2300/00

Abstract: PROBLEM TO BE SOLVED: To provide an antiseptic power enhancer developing high antiseptic power even at a low concentration of an antiseptic agent, to provide an antiseptic power enhancing composition comprising the enhancer and to provide a method for enhancing the antiseptic power of the antiseptic agent.
SOLUTION: (1) The antiseptic power enhancer of the antiseptic comprises an amphiphilic galactose derivative (A) as an active ingredient. (2) The antiseptic power enhancing composition comprises 0.01-30 mass% of the amphiphilic galactose derivative (A) and 0.01-1.0 mass% of the antiseptic agent (B). (3) The method for enhancing the antiseptic power of an antiseptic agent composition comprises making 0.01-30 mass% of the amphiphilic galactose derivative (A) coexist with the antiseptic agent (B) in the antiseptic agent composition.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 解决的问题：为了提供即使在低浓度的防腐剂中也产生高消毒力的防腐功率增强剂，提供一种包含该增强剂的防腐功能增强组合物，并提供一种提高抗菌能力的方法， 防腐剂。 解决方案：（1）防腐剂的防腐功效增强剂包含两亲性半乳糖衍生物（A）作为活性成分。 （2）防腐功效增强组合物含有0.01〜30质量％的两亲性半乳糖衍生物（A）和0.01〜1.0质量％的防腐剂（B）。 （3）提高防腐剂组合物的防腐功能的方法，其特征在于，在所述防腐剂组合物中，使所述两亲性半乳糖衍生物（A）中的0.01〜30质量％与所述防腐剂（B）共存。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JPH0977728A

公开(公告)日：1997-03-25

申请号：JP23135495

申请日：1995-09-08

Applicant: KAO CORP

Inventor： ABE HIDEYUKI ,  MIZUSHIMA YOUSEN

IPC: C07C231/02 ,  C07C231/12 ,  C07C233/47 ,  C07C233/49

Abstract: PROBLEM TO BE SOLVED: To obtain the subject useful compound applicable to various fields due to excellent surface-active and antimicrobial actions, etc., possessed thereby and its low irritant properties. SOLUTION: A compound represented by formula II [M and M are each H or a cation; (m) and (n) are each a number of 1-3] is reacted with an acid halide of the formula RCOX (R is a 5-21C alkyl, an alkenyl or a hydroxyalkyl; X is a halogen) and the salt exchange, as necessary, is then carried out to afford an N-long-chain acyliminodibasic acid represented by formula I or its salt. The resultant reactional solution is regulated to pH0-4 with an acid and the prepared reactional solution containing the compound, represented by formula I and kept in a melted state (a liquefied state) is further separated into an aqueous layer and an organic layer. The objective compound contained in the organic layer is separated and obtained therefrom. The resultant compound, as necessary, is neutralized and purified into a high purity. A lower alcohol such as ethanol or isopropyl alcohol is preferably added as a demulsifying agent to the reactional solution in the synthetic reaction.

公开(公告)号：JPH08283228A

公开(公告)日：1996-10-29

申请号：JP8688595

申请日：1995-04-12

Applicant: KAO CORP

Inventor： TAKAHASHI MASAKATSU ,  MIZUSHIMA YOUSEN ,  KABARU TAKESHI ,  FUJIO AKIRA

IPC: B01J27/02 ,  B01J31/02 ,  C07B61/00 ,  C07C303/24 ,  C07C305/06 ,  C07C305/10 ,  C11D1/29

Abstract: PURPOSE: To simply and safely obtain the subject compound in a high reaction rate excellent in foamability, safety and color tone and useful for various kinds of detergents by sulfurating an N-alkylamidoalkanol in the presence of a specific alkane. CONSTITUTION: (B) A compound of formula I [R is a 6-22C (branched) alkyl, alkenyl, hydroxyalkyl, alkylphenyl (the alkyl has 8-12 carbon atoms); R is H, a 1-22C (branched) alkyl, alkenyl, hydroxyalkyl, alkylphenyl (the alkyl has 8-12 carbon atoms); R is a 1-5C (branched) alkylene; R is a 2-3C (branched) alkylene; (n) is 0-50 which is the average addition mole number of alkylene oxide] is sulfurated with (C) a sulfurating agent in the presence of (A) a linear, branched or cyclic 5-22C alkane and, if necessary, further neutralized to obtain a compound of formula II (M is H, a cation).

公开(公告)号：JPH07109296A

公开(公告)日：1995-04-25

申请号：JP25161593

申请日：1993-10-07

Applicant: KAO CORP

Inventor： MIZUSHIMA YOUSEN

IPC: C07J9/00 ,  C07C59/76 ,  C07C67/08 ,  C07J75/00

Abstract: PURPOSE:To obtain the derivative of high quality with hardly any content of disterol esters which are by-products by thermally melting an alkenylsuccinic or an alkylsuccinic anhydride and then reacting the resultant melt with sterols. CONSTITUTION:This method for producing the objective sterol derivative expressed by formula IV [R is a residue remaining after removing H of hydroxyl group in sterols; R is a group expressed by formula II or III (R is a 6-20C alkenyl or alkyl)] is to thermally melt (A) an alkenylsuccinic or an alkylsuccinic anhydride expressed by formula I, then add (B) a natural sterol having one hydroxyl group or a hydrogenated substance thereof (hereinafter referred to as sterols, preferably cholesterol) thereto continuously or dividedly two or more times (preferably three or more times) at preferably 60-140 deg.C temperature requiring at least >=10min, preferably >=30min under stirred conditions and subsequently age the resultant mixture at 90-140 deg.C. Furthermore, the component (B) is preferably used in a molar amount of 0.9-1.1 times based on 1mol component (A).

公开(公告)号：JPH07109291A

公开(公告)日：1995-04-25

申请号：JP25161693

申请日：1993-10-07

Applicant: KAO CORP

Inventor： MIZUSHIMA YOUSEN ,  MAEDA TOSHIJI

IPC: C07J9/00 ,  C07C59/76 ,  C07J75/00

Abstract: PURPOSE:To economically obtain the derivative, having no malodor such as an olefin or an animal smell and capable of being blended with a cosmetic, etc., without carrying out the post-treatment according to a simple operation by reacting an alkenylsuccinic or an alkylsuccinic anhydride with sterols and then bringing the resultant compound into contact with an inert gas. CONSTITUTION:This method for producing a sterol derivative expressed by formula IV (R is a residue after removing H atom of OH group in sterols; formula V is a group binding to 0 atom to which the H atom of the OH group in the sterols is bound; [R is a group expressed by formula II or III (R is a 6-20C alkenyl or alkyl)] is to react (A) an alkenylsuccinic or an alkylsuccinic anhydride expressed by formula I with (B) natural sterol having one OH group or a hydrogenated substance thereof and then bring the resultant reactional product into contact with an inert gas or steam. Furthermore, the inert gas is preferably N, He or Ar and the inert gas or steam is preferably brought into contact with the prepared reactional product at 50-150 deg.C under reduced pressure. Water is preferably used in place of the steam and cholesterol is preferably used as the component (B).

公开(公告)号：JPH05140031A

公开(公告)日：1993-06-08

申请号：JP30630491

申请日：1991-11-21

Applicant: KAO CORP

Inventor： IMANAKA TAKEHIRO ,  MIZUSHIMA YOUSEN ,  FUJIO AKIRA ,  YOKOTA YUKINAGA

IPC: B01F17/00 ,  C07C59/305 ,  C11D1/08

Abstract: PURPOSE:To obtain a new carboxylic acid or its salt, excellent in curing resistance and foaming properties and useful as a surfactant capable of contributing to improvement in detergency. CONSTITUTION:A carboxylic acid expressed by formula 1 [R is 3-22C straight- chain or branched chain alkyl or alkenyl; M to M are H, alkali metal, ammonium, 2-9C alkanolammonium, 1-5C alkyl-substituted ammonium or basic amino acid group; M and M together form alkaline earth metal; (m) is 1-9] or its salt, e.g. trisodium carboxymethyloxy-decylmalonate. The compound expressed by formula 1 is obtained by reacting, e.g. a compound expressed by formula 2 as a starting raw material with halogen molecules X2, providing a compound expressed by formula 3, then hydrolyzing the resultant compound with an alkali metallic hydroxide, affording a compound expressed by formula 4, subsequently reacting a compound expressed by formula (c) or (d), providing a compound expressed by formula 5, finally hydrolyzing the compound expressed by formula 5 and, as necessary, carrying out salt exchange.

公开(公告)号：JPH04214770A

公开(公告)日：1992-08-05

申请号：JP34108090

申请日：1990-11-30

Applicant: KAO CORP

Inventor： YONEDA YASUHIRO ,  YAMAMOTO YUZO ,  MIZUSHIMA YOUSEN

IPC: B22F1/02 ,  C09C1/62 ,  C09D5/24 ,  H05K1/09 ,  H05K9/00

Abstract: PURPOSE:To obtain the subject treating agent capable of remarkably improving the heat-resistance and moisture-resistant reliability of copper powder by using a specific phenol adduct, a polyhydroxystyrene (derivative) and a hydroxystyrene copolymer (derivative) as main components. CONSTITUTION:The objective treating agent capable of improving the affinity of copper powder to a resin binder is composed mainly of (A) a monohydric or polyhydric phenol adduct of an unsaturated fatty acid (ester), (B) a monohydric or polyhydric phenol adduct of an unsaturated fatty acid (ester) of the component A wherein the phenol in the component A is an (un)saturated fatty acid ester, (C) a monohydric or polyhydric phenol adduct of an unsaturated fatty acid (ester) of the component A wherein the phenol in the component A is an arylsulfonated product or arylaminated product and (D) a polyhydroxystyrene (derivative) and/or (E) a hydroxystyrene copolymer (derivative).

公开(公告)号：JP2005281292A

公开(公告)日：2005-10-13

申请号：JP2004336923

申请日：2004-11-22

Applicant: Kao Corp ,  花王株式会社

Inventor： MIYAJIMA TETSUYA ,  IHARA TAKESHI ,  MIZUSHIMA YOUSEN

IPC: A61K8/30 ,  A61K8/02 ,  A61K8/42 ,  A61K31/16 ,  A61P17/16 ,  A61Q13/00 ,  C07C233/05 ,  C07C233/18 ,  C09K3/00 ,  C11B9/00 ,  A61K7/00

CPC classification number: A61K8/42 ,  A61Q13/00 ,  C07C233/05 ,  Y10S424/05

Abstract: PROBLEM TO BE SOLVED: To provide a gelatinizing agent which is excellent in gelatinizing performance against an oily substrate and yields a gel composition with a high gel strength and a high transparency.
SOLUTION: The gelatinizing agent containing an amide compound of formula (1) (wherein R1, R2 and R3 are each a hydrogen atom or a 1-3C alkyl group; R4, R5 and R6 are each a 6-24C hydrocarbon group optionally containing at least one chosen from an ether group, an amide group, an ester group, an amino group and a hydroxy group; and m, n and p are each an integer of 0-3) is used.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题：提供一种对油性基质的凝胶化性能优异的凝胶化剂，并产生具有高凝胶强度和高透明度的凝胶组合物。 解决方案：含有式（1）的酰胺化合物（其中R 1，R 2和R 3各自为氢原子或1-3C烷基; R 4，R 5和R 6各自为6-24C烃基的胶凝剂 任选地含有选自醚基，酰胺基，酯基，氨基和羟基中的至少一种; m，n和p各自为0-3的整数）。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2001322931A

公开(公告)日：2001-11-20

申请号：JP2000141525

申请日：2000-05-15

Applicant: KAO CORP

Inventor： OBA TAKASHI ,  MIZUSHIMA YOUSEN ,  SONE HAJIME ,  YAMAMURO AKIRA ,  HOTTA MITSUYUKI

IPC: A61K8/30 ,  A61K8/00 ,  A61K8/06 ,  A61K31/09 ,  A61P9/08 ,  A61P17/00 ,  A61Q5/00 ,  A61Q7/00 ,  C07C43/205 ,  A61K7/00 ,  A61K7/06

Abstract: PROBLEM TO BE SOLVED: To provide a blood flow improving agent and an external agent composition having excellent blood flow improving effect and giving little skin stimulating feeling undesirable to the human body. SOLUTION: The blood flow improving agent is composed of a methoxy- substituted phenyl alkoxyalkyl ether derivative expressed by general formula (1) [R1 is H or methoxy; X is a 2-6C alkylene; R2 is a 1-18C alkyl or a 7-24C aralkyl; and (n) is 1-5] and the external agent composition contains the compound.