公开(公告)号：EP4032982A1

公开(公告)日：2022-07-27

申请号：EP20835401.9

申请日：2020-06-25

Applicant: Korea Institute of Science and Technology ,  Algaeprona Inc.

Inventor： PAN, Cheol-Ho ,  ERDENEDOLGOR, Erdene-Ochir ,  SONG, Dae-geun ,  SHIN, Bok-Kyu ,  KWON, Byeori

IPC: C12N15/79 ,  C12N15/67 ,  C12P21/00 ,  C07K7/08

Abstract: The present invention relates to a novel promoter HASP1 for inducing overexpression of a protein in Phaeodactylum tricornutum, a signal peptide HASP1-SP, which is a novel protein secretion sequence for inducing the secretion of the expressed protein, an expression vector including the promoter HASP1 and the HASP1-SP-encoding sequence, a transformant in which the expression vector has been introduced into a host cell, a method for producing a protein of interest including a step of culturing the transformant to obtain a culture, a method for expressing a protein of interest including a step of transforming a host cell with the expression vector, and a method for increasing an expression level of a protein of interest in a host cell including a step of transforming the host cell with the expression vector. The novel promoter HASP1 for inducing overexpression of a protein in Phaeodactylum tricornutum, the signal peptide HASP1-SP, which is a novel protein secretion sequence for inducing the secretion of the expressed protein, and the expression vector including the promoter HASP1 and the HASP1-SP-encoding sequence may be used as strong genetic tools capable of significantly increasing productivity of recombinant proteins.

公开(公告)号：EP3705137A2

公开(公告)日：2020-09-09

申请号：EP18874248.0

申请日：2018-10-19

Applicant: Korea Institute of Science and Technology ,  Industry-Academic Cooperation Foundation, Yonsei University

Inventor： JUNG, Sang Hoon ,  KIM, Young-Joo ,  SONG, Dae-geun ,  PARK, Young Nyun ,  YOO, Jeong Eun ,  RHEE, Hyung Jin ,  JEON, Youngsic

IPC: A61K48/00 ,  A61K39/395 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/574

Abstract: In the present specification, on the basis of the correlation between prospero homeobox protein 1 (PROX1) and telomerase reverse transcriptase (TERT), a composition for regulating expression of TERT, a method for screening a TERT expression regulator, a composition for diagnosing a TERT expression status, a diagnostic kit, a method for providing information for diagnosis, or a method for providing information for cancer diagnosis are disclosed. Specifically, in one aspect, the PROX1 of the present disclosure may bind to a TERT promoter, in particular a mutant TERT promoter in which base substitution occurs at the -124 or -146 bp position to regulate the expression of TERT, and the expression of TERT in non-hepatitis B virus-associated liver cancer can be inhibited specifically among liver cancers. Accordingly, the present disclosure may be utilized in various biomedical fields including compositions for regulating the expression of TERT, compositions for preventing, ameliorating or treating hepatitis B virus-associated liver cancer, and the like.

公开(公告)号：EP4467148A1

公开(公告)日：2024-11-27

申请号：EP23743450.1

申请日：2023-01-18

Applicant: Korea Institute of Science and Technology

Inventor： CHOI, Ki Young ,  HAN, Hwa Seung ,  CHA, Kwang-Hyun ,  SONG, Dae-geun ,  PARK, Jin Soo ,  LEE, Choong-Gu ,  KIM, Myung Suk

IPC: A61K35/74 ,  A61K35/745 ,  A61P1/16 ,  A23L33/135 ,  A23K10/16

Abstract: The present invention relates to a composition for the prevention, amelioration or treatment of non-alcoholic fatty liver disease (NAFLD), comprising a Roseburia spp. strain, a Bifidobacterium spp. strain, or extracellular vesicles (EVs) derived therefrom. The Roseburia spp. strain, the Bifidobacterium spp. strain, or the EVs derived therefrom, according to the present invention, can restore liver function, ameliorate liver steatosis and inflammation, and suppress liver fibrosis, and thus can be provided as a composition for the prevention, amelioration or treatment of NAFLD.

公开(公告)号：EP3620166A1

公开(公告)日：2020-03-11

申请号：EP19168464.6

申请日：2019-04-10

Applicant: Korea Institute of Science and Technology

Inventor： PAN, Cheol-Ho ,  KIM, Sang Min ,  KOO, Song Yi ,  CHA, Kwang-Hyun ,  LEE, Eun Ha ,  LEE, Hee Ju ,  YANG, Jung-Seok ,  CHOI, Yongsoo ,  KANG, Kyungsu ,  KIM, Hyoung Seok ,  SONG, Dae-geun

IPC: A61K36/02 ,  A61K9/14 ,  A61P3/04

Abstract: Disclosed are a composition for anti-obesity comprising a pulverized material of Odontella aurita as an active ingredient and a method of processing Odontella aurita to improve the anti-obesity effects. The pulverized material may be a microfluidizer-processed pulverized material of Odontella aurita. The pulverized material exhibits the effect of inhibiting weight gain and the effect of inhibiting body fat accumulation in mice fed with a high-fat diet.

公开(公告)号：EP4467147A1

公开(公告)日：2024-11-27

申请号：EP23743449.3

申请日：2023-01-18

Applicant: Korea Institute of Science and Technology

Inventor： CHOI, Ki Young ,  CHA, Kwang-Hyun ,  HAN, Hwa Seung ,  PARK, Jin Soo ,  SONG, Dae-geun ,  KIM, Myung Suk ,  KWON, Hak Cheol

IPC: A61K35/74 ,  A61K35/745 ,  A61P29/00 ,  A23L33/135 ,  A23K10/16 ,  A61P1/00

Abstract: The present invention relates to a composition for preventing, ameliorating, or treating inflammatory diseases comprising extracellular vesicles (EVs) derived from Roseburia spp. strains and/or Bifidobacterium spp. strains. The EVs of the present invention exhibits effectiveness in improving inflammatory bowel disease (IBD), and additionally, all EVs derived from congeneric strains corresponding to Roseburia spp. strains or Bifidobacterium spp. strains. have been confirmed to exhibit strong anti-inflammatory effect. As such, the strain of the present invention and EVs derived therefrom can be provided as a composition for preventing, ameliorating, or treating a variety of inflammatory diseases.

公开(公告)号：EP3590522A1

公开(公告)日：2020-01-08

申请号：EP18210806.8

申请日：2018-12-06

Applicant: Korea Institute of Science and Technology ,  Republic of Korea Management: Rural Development Administration

Inventor： CHOI, Yongsoo ,  KIM, Jin-Chul ,  KIM, Su-Nam ,  KANG, Kyungsu ,  YANG, Seung-Hoon ,  PARK, Keunwan ,  LEE, Hee Ju ,  SONG, Dae-geun ,  CHA, Kwang-Hyun ,  JEON, Joo Yeong ,  KIM, Chang Geon ,  MOON, Jung Kyung ,  CHOI, Man Soo ,  PARK, Soo Kwon ,  JEONG, Nam Hee

IPC: A61K36/48 ,  A61P29/00

Abstract: Provided are a composition for preventing or improving inflammation, the composition including an extract of a seed of soybean Glycine max (L.) Merrill cultivar SCEL-1, and a method of preventing occurrence of inflammation in a subject or improving inflammation in a subject, the method including injecting the composition to a subject.