公开(公告)号：WO2009131263A1

公开(公告)日：2009-10-29

申请号：PCT/KR2008/002362

申请日：2008-04-25

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PAN, Cheol-Ho ,  LEE, Saet Byoul ,  KIM, Min Cheol ,  UM, Byung Hun ,  LEE, Eun Ha ,  LEE, Joo Young ,  NHO, Chu Won ,  JUNG, Sang Hoon

Inventor： PAN, Cheol-Ho ,  LEE, Saet Byoul ,  KIM, Min Cheol ,  UM, Byung Hun ,  LEE, Eun Ha ,  LEE, Joo Young ,  NHO, Chu Won ,  JUNG, Sang Hoon

IPC: A61K36/03 ,  A61P35/00

CPC classification number: A61K36/03 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/21

Abstract: Provided is a composition for cancer chemoprevention comprising the extract of the seaweed Cutleria cylindrica . Specifically, the composition for cancer chemoprevention according to the present invention comprising the extract obtained by extracting Cutleria cylindrica with ethanol, which activates quinone reductase, an anticarcinogenic enzyme, is without cell toxicity, and provides cancer chemoprevention effect by inducing activation of the phase II detoxifying enzyme system although not inducing activation of the phase I detoxifying enzyme system, as active ingredient can be useful as medicine or health functional food for cancer prevention.

Abstract translation: 提供了一种用于癌症化学预防的组合物，其包含海藻Cutleria cylindrica的提取物。 具体而言，本发明的癌症化学预防用组合物，其特征在于，含有通过用活化醌还原酶的乙醇萃取的抗胆碱酯酶提取的提取物不含细胞毒性，通过诱导II期解毒的活化而提供癌症化学预防效果 酶系统虽然不能诱导I相脱氧酶系统的活化，但作为活性成分可用作癌症预防的药物或保健功能食品。

公开(公告)号：WO2008150074A2

公开(公告)日：2008-12-11

申请号：PCT/KR2008/002806

申请日：2008-05-20

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  JUNG, Sang Hoon ,  LEE, Eun Ha ,  PAN, Cheol-Ho ,  KIM, Chul Young ,  UM, Byung Hun ,  LEE, Dong-Un ,  SONG, Dae Geun ,  LEE, Joo Young

Inventor： JUNG, Sang Hoon ,  LEE, Eun Ha ,  PAN, Cheol-Ho ,  KIM, Chul Young ,  UM, Byung Hun ,  LEE, Dong-Un ,  SONG, Dae Geun ,  LEE, Joo Young

IPC: A61K36/22 ,  A61K31/34 ,  A61P3/00

CPC classification number: A61K36/22 ,  A61K31/34

Abstract: The present invention relates to a composition for prevention and treatment of diabetic complications containing the extracts of Rhus verniciflua, fractions thereof and compounds isolated therefrom as an active ingredient, more precisely a composition for prevention and treatment of diabetic complications which comprises the extracts of Rhus verniciflua extracted by using water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom as an active ingredient. The extracts of Rhus verniciflua extracted by- using water, alcohol or a mixture thereof as a solvent, fractions thereof and compounds isolated therefrom were confirmed to have inhibitory effect on aldose reductase causing accumulation of sorbitol which is one of major causes of diabetic complications and on advanced glycation end procuct without cytotoxicity, so that they were confirmed to be safe materials effectively used for the composition for prevention and treatment of diabetic complications.

Abstract translation: 本发明涉及一种预防和治疗含有紫荆提取物及其分离物及其分离自其中的化合物作为活性成分的糖尿病并发症的组合物，更准确地说，涉及预防和治疗糖尿病并发症的组合物，其包含紫草提取物 通过使用水，醇或其混合物作为溶剂萃取，其馏分和作为活性成分从其中分离出的化合物。 通过使用水，醇或其混合物作为溶剂提取的Rhus verniciflua的提取物，其级分和从其分离的化合物被证实对引起糖尿病并发症的主要原因之一的山梨糖醇积累的醛糖还原酶具有抑制作用，并且对 晚期糖基化终末没有细胞毒性，因此被证实是有效用于预防和治疗糖尿病并发症的组合物的安全材料。

公开(公告)号：EP4000421A1

公开(公告)日：2022-05-25

申请号：EP21208822.3

申请日：2021-11-17

Applicant: Korea Institute of Science and Technology

Inventor： PAN, Cheol Ho ,  KIM, Jin Chul ,  LEE, Eun Ha ,  HONG, Sung Chul ,  KIM, Ju Yong ,  LEE, Eun Young

IPC: A23L33/00 ,  A61K36/05

Abstract: Disclosed is a composition used to prevent, ameliorate, or treat an inflammatory bowel disease containing Tisochrysis lutea as an active ingredient.

公开(公告)号：EP3868443A1

公开(公告)日：2021-08-25

申请号：EP20195631.5

申请日：2020-09-11

Applicant: Korea Institute of Science and Technology

Inventor： PAN, Cheol-Ho ,  KIM, Jin-Chul ,  PARK, Keunwan ,  LEE, Eun Ha

IPC: A61P27/02 ,  A61K36/03

Abstract: Provided are a composition and a health functional food, each including Tisochrysis lutea as an active ingredient, for preventing or treating an eye disease. The composition and the health functional food may increase tear production or may repair corneal injury, and thus may be useful in preventing, treating, or improving eye diseases.

公开(公告)号：EP3620166A1

公开(公告)日：2020-03-11

申请号：EP19168464.6

申请日：2019-04-10

Applicant: Korea Institute of Science and Technology

Inventor： PAN, Cheol-Ho ,  KIM, Sang Min ,  KOO, Song Yi ,  CHA, Kwang-Hyun ,  LEE, Eun Ha ,  LEE, Hee Ju ,  YANG, Jung-Seok ,  CHOI, Yongsoo ,  KANG, Kyungsu ,  KIM, Hyoung Seok ,  SONG, Dae-geun

IPC: A61K36/02 ,  A61K9/14 ,  A61P3/04

Abstract: Disclosed are a composition for anti-obesity comprising a pulverized material of Odontella aurita as an active ingredient and a method of processing Odontella aurita to improve the anti-obesity effects. The pulverized material may be a microfluidizer-processed pulverized material of Odontella aurita. The pulverized material exhibits the effect of inhibiting weight gain and the effect of inhibiting body fat accumulation in mice fed with a high-fat diet.

公开(公告)号：EP3517175A1

公开(公告)日：2019-07-31

申请号：EP19152993.2

申请日：2019-01-22

Applicant: Korea Institute of Science and Technology

Inventor： PAN, Cheol-Ho ,  KANG, Kyungsu ,  KIM, Sang Min ,  JUNG, Sang Hoon ,  AHN, Hong Ryul ,  EOM, Jae-In ,  KOO, Song Yi ,  CHOI, Yongsoo ,  YANG, Jung-Seok ,  LEE, Eun Ha ,  LEE, Hee Ju ,  KIM, Kyung A

IPC: A61P27/06 ,  A61K36/05 ,  A23L17/00 ,  A61P27/02

Abstract: The present disclosure discloses a composition for improving eye health comprising Tetraselmis sp. microalgae; a culture thereof; a crushed material thereof; or an extract of the microalgae, the culture or the crushed material as an active ingredient. The composition inhibits retinal optic nerve damage and thereby improves eye health.