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公开(公告)号：WO2010093726A8
公开(公告)日：2011-05-12
申请号：PCT/US2010023793
申请日：2010-02-10
Applicant: LIFE TECHNOLOGIES CORP , HU YI-ZHEN , KANG HEE CHOL
Inventor： HU YI-ZHEN , KANG HEE CHOL
IPC: C07D403/14 , C07D403/06 , C07D403/10
CPC classification number: C07H19/207 , C07D209/14 , C07D209/26 , C07D401/10 , C07D401/14 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B23/164 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1022 , C09K2211/1044 , C09K2211/1059 , C09K2211/1074 , G01N33/52
Abstract: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.
Abstract translation: 本文提供具有大斯托克斯位移的七甲川花青染料及其盐和共轭物。 还提供了使用和制造如荧光共振能量转移（FRET）受体或供体这样的大斯托克斯位移染料的方法。
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公开(公告)号：CA3107758A1
公开(公告)日：2020-02-13
申请号：CA3107758
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORP
Inventor： YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , EVANS BRIAN , RUKAVISHNIKOV ALEKSEY
IPC: C09B69/00 , C09B11/14 , C12Q1/6869 , G01N33/58
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are Si R dyes comprising at least one vinyl groupattached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of Si R compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples. The compounds have the general structure (I) below.
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公开(公告)号：CL2021000340A1
公开(公告)日：2021-07-02
申请号：CL2021000340
申请日：2021-02-09
Applicant: LIFE TECHNOLOGIES CORP
Inventor： EVANS BRIAN , YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , RUKAVISHNIKOV ALEKSEY
IPC: C09B11/14 , C09B69/00 , C12Q1/6869 , G01N33/58
Abstract: Los compuestos de rodamina sustituidos con silicio se describen en la presente. En la presente se describen también tintes de SiR que comprenden al menos un grupo vinilo unido al átomo de Si (posición 10) del tinte de SiR. También se proporcionan derivados, versiones funcionalizadas, conjugados, kits, métodos sintéticos relacionados y usos de compuestos de SiR. Los tintes de silicio-rodamina (SiR) pueden proporcionar una fluorescencia brillante en longitudes de onda de rojo lejano y mostrar buena fotoestabilidad. Los compuestos descritos en la presente pueden ser útiles para el marcado fluorescente y la detección de muestras biológicas.
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Patent Agency Ranking
公开(公告)号：WO2010093726A3
公开(公告)日：2011-03-31
申请号：PCT/US2010023793
申请日：2010-02-10
Applicant: LIFE TECHNOLOGIES CORP , HU YI-ZHEN , KANG HEE CHOL
Inventor： HU YI-ZHEN , KANG HEE CHOL
IPC: C07D403/14 , C07D403/06 , C07D403/10
CPC classification number: C07H19/207 , C07D209/14 , C07D209/26 , C07D401/10 , C07D401/14 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B23/164 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1022 , C09K2211/1044 , C09K2211/1059 , C09K2211/1074 , G01N33/52
Abstract: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.
Abstract translation: 本文提供具有大的斯托克斯位移的七甲基氰花青染料及其盐和共轭物。 还提供了使用和制备这种大的斯托克斯位移染料作为荧光共振能量转移（FRET）受体或供体的方法。
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公开(公告)号：SG11202101282QA
公开(公告)日：2021-03-30
申请号：SG11202101282Q
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORP
Inventor： YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , EVANS BRIAN , RUKAVISHNIKOV ALEKSEY
IPC: C09B69/00 , C09B11/14 , C12Q1/6869 , G01N33/58
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are SiR dyes comprising at least one vinyl group attached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of SiR compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples.
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公开(公告)号：AU2019319901B2
公开(公告)日：2022-07-07
申请号：AU2019319901
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORP
Inventor： YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , EVANS BRIAN , RUKAVISHNIKOV ALEKSEY
IPC: C09B69/00 , C09B11/14 , C12Q1/6869 , G01N33/58
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are Si R dyes comprising at least one vinyl groupattached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of Si R compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples. The compounds have the general structure (I) below.
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公开(公告)号：AU2019319901A1
公开(公告)日：2021-02-18
申请号：AU2019319901
申请日：2019-08-08
Applicant: LIFE TECHNOLOGIES CORP
Inventor： YANG JONGTAE , WANG XIN , HU YI-ZHEN , GEE KYLE , CHEN AIMEI , BENSON SCOTT , EVANS BRIAN , RUKAVISHNIKOV ALEKSEY
IPC: C09B69/00 , C09B11/14 , C12Q1/6869 , G01N33/58
Abstract: Silicon-substituted rhodamine compounds are disclosed herein. Also described herein are Si R dyes comprising at least one vinyl groupattached to the Si atom (10 position) of the SiR dye. Derivatives, functionalized versions, conjugates, kits, related synthetic methods and uses of Si R compounds also are provided. Silicon-rhodamine (SiR) dyes can provide bright fluorescence at far red wavelengths and exhibit good photostability. The compounds described herein can be useful for fluorescent labeling and detection of biological samples. The compounds have the general structure (I) below.
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公开(公告)号：EP2396318A4
公开(公告)日：2013-06-05
申请号：EP10741680
申请日：2010-02-10
Applicant: LIFE TECHNOLOGIES CORP
Inventor： HU YI-ZHEN , KANG HEE CHOL
IPC: C07D403/14 , C07D403/06 , C07D403/10
CPC classification number: C07H19/207 , C07D209/14 , C07D209/26 , C07D401/10 , C07D401/14 , C09B23/0041 , C09B23/0066 , C09B23/086 , C09B23/164 , C09K11/06 , C09K2211/1007 , C09K2211/1014 , C09K2211/1022 , C09K2211/1044 , C09K2211/1059 , C09K2211/1074 , G01N33/52
Abstract: Provided herein are heptamethine cyanine dyes having a large Stokes shift, and the salts and conjugates thereof. Also provided are methods of using and making such large Stokes shift dyes as fluorescence resonance energy transfer (FRET) acceptors or donors.
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