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    Corante de rodamina assimétrica e uso da mesma em ensaios biológicos
    1.
    发明专利
    Corante de rodamina assimétrica e uso da mesma em ensaios biológicos 未知

    公开(公告)号：BR112021012154A2

    公开(公告)日：2021-09-08

    申请号：BR112021012154

    申请日：2019-12-20

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： EVANS BRIAN ,  BENSON SCOTT

    IPC: C07H21/00 ,  C09B11/24 ,  C12N15/65 ,  G01N33/58

    Abstract: corante de rodamina assimétrica e uso da mesma em ensaios biológicos. a presente divulgação se refere a corantes nh-rodamina n-protegida e seu uso na detecção de ácido nucleico. em particular, a divulgação se refere a métodos de produção de corantes nh-rodamina n protegida e métodos de uso de corantes nh-rodamina n-protegida (por exemplo, identificação humana). certos corantes fornecidos neste documento têm propriedades espectrais únicas que complementam aquelas em conjuntos de corantes existentes e podem ser usados para expandir o número de corantes repórter que podem ser incluídos para aplicações hid e outros ensaios biológicos. esses compostos fluorescentes são úteis para marcar oligonucleotídeos sintéticos. fórmula (i).

    Asymmetric rhodamine dye and use thereof in biological assays
    2.
    发明专利
    Asymmetric rhodamine dye and use thereof in biological assays 未知

    公开(公告)号：AU2019404556A1

    公开(公告)日：2021-06-24

    申请号：AU2019404556

    申请日：2019-12-20

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： EVANS BRIAN ,  BENSON SCOTT

    IPC: C09B11/24 ,  C07H21/00 ,  C12N15/65 ,  G01N33/58

    Abstract: The present disclosure relates to N-protected NH-rhodamine dyes and their use in nucleic acid detection. In particular, the disclosure relates to methods of making N-protected NH-rhodamine dyes, and methods of use of N-protected NH-rhodamine dyes (e.g., human identification). Certain dyes provided herein have unique spectral properties that complement those in existing dye sets and can be used to expand the number of reporter dyes that can be included for HID applications and other biological assays. Those fluorescent compounds are useful to label synthetic oligonucleotides. Formula (I).

    ASYMMETRIC RHODAMINE DYE AND USE THEREOF IN BIOLOGICAL ASSAYS
    3.
    发明专利
    ASYMMETRIC RHODAMINE DYE AND USE THEREOF IN BIOLOGICAL ASSAYS 未知

    公开(公告)号：CA3124361A1

    公开(公告)日：2020-06-25

    申请号：CA3124361

    申请日：2019-12-20

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： EVANS BRIAN ,  BENSON SCOTT

    IPC: C09B11/24 ,  C07H21/00 ,  C12N15/65 ,  G01N33/58

    Abstract: The present disclosure relates to N-protected NH-rhodamine dyes and their use in nucleic acid detection. In particular, the disclosure relates to methods of making N-protected NH-rhodamine dyes, and methods of use of N-protected NH-rhodamine dyes (e.g., human identification). Certain dyes provided herein have unique spectral properties that complement those in existing dye sets and can be used to expand the number of reporter dyes that can be included for HID applications and other biological assays. Those fluorescent compounds are useful to label synthetic oligonucleotides. Formula (I).

    10.
    发明专利
    未知

    公开(公告)号：AT546494T

    公开(公告)日：2012-03-15

    申请号：AT04075950

    申请日：1998-09-18

    Applicant: LIFE TECHNOLOGIES CORP

    Inventor： BENSON SCOTT ,  MENCHEN STEVEN MICHAEL ,  THEISEN PETER DAVID ,  UPADHYA KRISHNA ,  HAUSER JOAN DALE

    IPC: C09B11/08 ,  G01N21/64 ,  C07D311/82 ,  C07D407/14 ,  C07D493/04 ,  C07D493/14 ,  C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C09B11/24 ,  C09B11/28 ,  C09K11/06 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/78 ,  G01N33/533 ,  G01N33/58

    Abstract: A class of aromatic-substituted xanthene compounds useful as fluorescent dyes is disclosed, the compounds having general structure (I), where Y1 and Y2 taken separately are selected from the group consisting of hydroxyl, oxygen, imminium, linking group and amine, or Y1 taken together with R2 is cyclic imine, or Y2 taken together with R3 is cyclic amine; R2, R3, R5, and R7 taken separately are selected from the group consisting of hydrogen, fluorine, chlorine, lower alkyl, lower alkene, lower alkyne, sulfonate, sulfone, amino, imminium, amido, nitrile, lower alkoxy, phenyl, and linking group; R1 taken separately is selected from the group consisting of phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, linking-group and electron-rich heterocycle, or when taken together with R7 is selected from the group consisting of electron-rich heterocycle and indene; R4 taken separately is selected from the group consisting of amino, amido, phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, indene, linking group and electron-rich heterocycle, or when taken together with R5 is selected from the group consisting of phenyl, substituted phenyl, polycyclic aromatic, substituted polycyclic aromatic, indene, and electron rich heterocycle; and R6 is selected from the group consisting of acetylene, lower alkyl, lower alkene, cyano, phenyl, substituted phenyl, and heterocyclic aromatic. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labelled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides. In an additional aspect, the invention includes methods utilising such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.

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