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    DATA COMPRESSION OF WAVEFORMS ASSOCIATED WITH A CHEMICAL EVENT OCCURING ON A SENSOR ARRAY
    1.
    发明申请
    DATA COMPRESSION OF WAVEFORMS ASSOCIATED WITH A CHEMICAL EVENT OCCURING ON A SENSOR ARRAY 审中-公开
    与传感器阵列相关的化学事件相关的波形的数据压缩

    公开(公告)号：WO2013096906A1

    公开(公告)日：2013-06-27

    申请号：PCT/US2012/071482

    申请日：2012-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： REARICK, Todd ,  BEAUCHEMIN, Mark

    IPC: G01N27/414 ,  G06F19/22 ,  H03M7/30

    CPC classification number: G01N27/4145 ,  C12Q1/6869 ,  G01N27/27 ,  G01N27/4148 ,  G06F19/22

    Abstract: A method, a computer program and an apparatus for measuring a waveform associated with a chemical event occurring on an ISFET sensor array. The waveform includes at least one region associated with expected measured values and at least one region associated with unpredictable measured values. First frame averaging is applied to at least one region associated with the expected measured values. Second frame averaging is applied to at least one region associated with the unpredictable measured values. The second number of frames used for averaging is less than the first number of frames. By the variable frame averaging the amount of stored data can be reduced.

    Abstract translation: 一种用于测量与在ISFET传感器阵列上发生的化学事件相关联的波形的方法，计算机程序和装置。 波形包括与预期测量值相关联的至少一个区域和与不可预测的测量值相关联的至少一个区域。 将第一帧平均应用于与预期测量值相关联的至少一个区域。 将第二帧平均应用于与不可预测的测量值相关联的至少一个区域。 用于平均的第二帧数小于第一帧数。 通过可变帧平均化，可以减少存储的数据量。

    ISFET SENSOR ARRAY COMPRISING TITANIUM NITRIDE AS A SENSING LAYER LOCATED THE BOTTOM OF A MICROWELL STRUCTURE
    4.
    发明申请
    ISFET SENSOR ARRAY COMPRISING TITANIUM NITRIDE AS A SENSING LAYER LOCATED THE BOTTOM OF A MICROWELL STRUCTURE 审中-公开
    ISFET传感器阵列包含硝酸铁作为传感层位于MICROWELL结构的底部

    公开(公告)号：WO2013109886A1

    公开(公告)日：2013-07-25

    申请号：PCT/US2013/022140

    申请日：2013-01-18

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  BUSTILLO, James ,  REARICK, Todd ,  HINZ, Wolfgang ,  FIFE, Keith

    Inventor： BUSTILLO, James ,  REARICK, Todd ,  HINZ, Wolfgang ,  FIFE, Keith

    IPC: G01N27/414

    CPC classification number: B01L3/5027 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/0893 ,  G01N27/4145

    Abstract: A method of fabricating a microwell in an array structure is disclosed herein. The array structure includes a plurality of field effect transistors (FETs), where each FET has a gate structure. The method includes disposing a titanium nitride (TiN) layer on at least one conductive layer coupled to the gate structure of at least one FET. A insulation layer is disposed on the array structure, where the insulation layer lies above the TiN layer. Further, an opening above the gate structure of the at least one FET is etched to remove the insulation layer above the gate structure and to expose the TiN layer. A microwell with at least one sidewall formed from the insulation layer and with a bottom surface formed from the TiN layer is a result of the etching process. The gate structure is specified as a floating gate structure and the FET is an ISFET.

    Abstract translation: 本文公开了一种制造阵列结构中的微孔的方法。 阵列结构包括多个场效应晶体管（FET），其中每个FET具有栅极结构。 该方法包括在耦合到至少一个FET的栅极结构的至少一个导电层上设置氮化钛（TiN）层。 绝缘层设置在阵列结构上，其中绝缘层位于TiN层上方。 此外，蚀刻至少一个FET的栅极结构之上的开口以去除栅极结构上方的绝缘层并暴露TiN层。 具有由绝缘层形成的至少一个侧壁和由TiN层形成的底表面的微孔是蚀刻工艺的结果。 栅极结构被指定为浮置栅极结构，FET是ISFET。

    METHOD AND APPARATUS FOR CALIBRATION OF A SENSOR ARRAY
    5.
    发明申请
    METHOD AND APPARATUS FOR CALIBRATION OF A SENSOR ARRAY 审中-公开
    传感器阵列校准的方法和装置

    公开(公告)号：WO2013096897A1

    公开(公告)日：2013-06-27

    申请号：PCT/US2012/071471

    申请日：2012-12-21

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： REARICK, Todd ,  DAVEY, Melville ,  BEAUCHEMIN, Mark

    IPC: G01N27/414

    CPC classification number: G01N27/4165 ,  G01N27/4145 ,  G06F19/22

    Abstract: A method, computer program product, and system are provided to calibrate a sensor array with a plurality of sensors. Preferably, the sensor array consists of a plurality of ISFETs which are in fluid communication with a reference electrode. A particular reference voltage is determined, which depends on the maximum value of the overall average gain of the sensors in an array, but also on a maximum number of sensors available for the measurement. The method includes sweeping a voltage of the reference electrode from a first voltage to a second voltage. The output voltage of each of the plurality of sensors is monitored at one or more voltages within the first and second voltages. The gain of each sensor at each of the one or more voltages is determined. An overall average gain of the plurality of sensors is calculated at each of the one or more voltages. Further, an acquisition window for the sensor array is determined. The acquisition window includes a maximum distribution of sensors that provides a maximal overall average gain at a particular reference electrode voltage.

    Abstract translation: 提供了一种方法，计算机程序产品和系统来校准具有多个传感器的传感器阵列。 优选地，传感器阵列由与参考电极流体连通的多个ISFET组成。 确定特定参考电压，其取决于阵列中传感器的总体平均增益的最大值，也取决于可用于测量的最大传感器数量。 该方法包括将参考电极的电压从第一电压扫到第二电压。 在第一和第二电压内的一个或多个电压下监视多个传感器中的每一个的输出电压。 确定在一个或多个电压中的每一个处的每个传感器的增益。 在一个或多个电压中的每一个处计算多个传感器的总平均增益。 此外，确定传感器阵列的采集窗口。 采集窗口包括在特定参考电极电压下提供最大总平均增益的传感器的最大分布。

    BYPASS FOR R-C FILTER IN CHEMICAL SENSOR ARRAYS
    6.
    发明申请
    BYPASS FOR R-C FILTER IN CHEMICAL SENSOR ARRAYS 审中-公开
    化学传感器阵列中R-C过滤器的旁路

    公开(公告)号：WO2013052825A1

    公开(公告)日：2013-04-11

    申请号：PCT/US2012/058996

    申请日：2012-10-05

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： REARICK, Todd

    IPC: G01N27/414 ,  C12Q1/68

    CPC classification number: G01N27/4148

    Abstract: In one implementation, a method is described for operating a chemical sensor. The method includes initiating a chemical reaction proximate to the chemical sensor. The method further includes, during a first time interval of the chemical reaction, closing a bypass switch placed in parallel with a resistor and arranged between an output terminal of the chemical sensor and a capacitor, thereby charging the capacitor to a first voltage based on a voltage at the output terminal due to the chemical reaction. The method further includes opening the bypass switch during a second time interval of the chemical reaction, thereby charging the capacitor to a second voltage based on the voltage at the output terminal. The method further includes generating an output signal for the chemical sensor based on the second voltage on the capacitor.

    Abstract translation: 在一个实施方案中，描述了用于操作化学传感器的方法。 该方法包括在化学传感器附近启动化学反应。 该方法还包括在化学反应的第一时间间隔期间，闭合与电阻并联放置的旁路开关，并布置在化学传感器的输出端和电容器之间，从而基于电容器将电容器充电到第一电压 由于化学反应，输出端子处的电压。 该方法还包括在化学反应的第二时间间隔期间打开旁路开关，从而基于输出端子处的电压将电容器充电到第二电压。 该方法还包括基于电容器上的第二电压产生用于化学传感器的输出信号。

    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS
    8.
    发明申请
    MODELS FOR ANALYZING DATA FROM SEQUENCING-BY-SYNTHESIS OPERATIONS 审中-公开
    用于分析合成数据的模型

    公开(公告)号：WO2012092455A2

    公开(公告)日：2012-07-05

    申请号：PCT/US2011/067776

    申请日：2011-12-29

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  REARICK, Todd ,  SCHULTZ, Jonathan

    Inventor： REARICK, Todd ,  SCHULTZ, Jonathan

    IPC: C12Q1/68 ,  G06F17/10 ,  C40B30/00

    CPC classification number: G06F19/24 ,  C12Q1/6869 ,  C12Q2527/119 ,  C12Q2563/159 ,  C12Q2565/607

    Abstract: Mathematical models for the analysis of signal data generated by sequencing of a polynucleotide strand using a pH-based method of detecting nucleotide incorporation(s). In an embodiment, the measured output signal from the reaction confinement region of a reactor array is mathematically modeled. The output signal may be modeled as a linear combination of one or more signal components, including a background signal component. This model is solved to determine the nucleotide incorporation signal. In another embodiment, the incorporation signal from the reaction confinement region of a reactor array is mathematically modeled.

    Abstract translation: 用于通过使用基于pH的检测核苷酸掺入的方法测序多核苷酸链产生的信号数据分析的数学模型。 在一个实施例中，来自反应堆阵列的反应限制区域的测量的输出信号在数学上被建模。 输出信号可以被建模为包括背景信号分量的一个或多个信号分量的线性组合。 该模型被解决以确定核苷酸掺入信号。 在另一个实施方案中，来自反应器阵列的反应限制区域的掺入信号在数学上被建模。

    APPARATUSES, METHODS, SYSTEMS, AND COMPUTER-READABLE MEDIA FOR FLUID POTENTIAL ARTIFACT CORRECTION IN REAGENT DELIVERY SYSTEMS
    9.
    发明申请
    APPARATUSES, METHODS, SYSTEMS, AND COMPUTER-READABLE MEDIA FOR FLUID POTENTIAL ARTIFACT CORRECTION IN REAGENT DELIVERY SYSTEMS 审中-公开
    设备，方法，系统和计算机可读介质，用于在试剂递送系统中进行流体潜在的矫正校正

    公开(公告)号：WO2016044141A1

    公开(公告)日：2016-03-24

    申请号：PCT/US2015/049935

    申请日：2015-09-14

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： WONG, Chiu, Tai Andrew ,  REARICK, Todd ,  DONOHUE, John

    IPC: G01N27/26

    CPC classification number: G01N27/4145 ,  G06F19/22

    Abstract: A method for correcting nucleotide incorporation signals for fluid potential effects or disturbances arising in nucleic acid sequencing-by-synthesis includes: disposing a plurality of template polynucleotide strands in a plurality of defined spaces disposed on a sensor array, the template polynucleotide strands having a sequencing primer and a polymerase bound therewith; exposing the template polynucleotide strands to a series of flows of nucleotide species flowed through a fluid manifold, the fluid manifold comprising passages for flowing nucleotide species and a branch passage for flowing a solution, the branch passage comprising a reference electrode and a sensing electrode; obtaining a plurality of nucleotide incorporation signals corresponding to the plurality of defined spaces, the nucleotide incorporation signals having a signal intensity related to a number of nucleotide incorporations; and correcting at least some of the plurality of nucleotide incorporation signals for fluid potential effects or disturbances.

    Abstract translation: 用于校正核酸并入信号的方法，用于在核酸序列合成中产生的流体潜在效应或紊乱，包括：将多个模板多核苷酸链设置在设置在传感器阵列上的多个限定的空间中，所述模板多核苷酸链具有测序 引物和与之结合的聚合酶; 将模板多核苷酸链暴露于流过流体歧管的一系列核苷酸物质流，该流体歧管包括用于流动核苷酸物种的通道和用于使溶液流动的分支通道，该分支通道包括参考电极和感测电极; 获得对应于所述多个限定空间的多个核苷酸掺入信号，所述核苷酸掺入信号具有与多个核苷酸结合相关的信号强度; 以及校正所述多个核苷酸并入信号中的至少一些用于流体潜在效应或干扰。

    SIGNAL CORRECTION FOR MULTIPLEXER CROSS-TALK IN CHEMICAL SENSOR ARRAYS
    10.
    发明申请
    SIGNAL CORRECTION FOR MULTIPLEXER CROSS-TALK IN CHEMICAL SENSOR ARRAYS 审中-公开
    化学传感器阵列中多路复用器的信号校正

    公开(公告)号：WO2013052837A1

    公开(公告)日：2013-04-11

    申请号：PCT/US2012/059014

    申请日：2012-10-05

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： REARICK, Todd

    IPC: G01N27/414 ,  C12Q1/68 ,  H04J3/10

    CPC classification number: G01N27/4148 ,  G01N27/4145 ,  H04J3/047

    Abstract: Method for processing signals from an integrated circuit device comprising a sensor array and a multiplexer that receives output signals from sensors of the sensor array. The method includes initiating one or more chemical reactions in proximity to sensors in the sensor array. The method further includes receiving a first output signal from a first sensor of the sensor array via a first channel of the multiplexer. The method further includes receiving a second output signal from a second sensor of the sensor array via a second channel of the multiplexer. The method further includes calculating an adjusted second output signal to compensate for cross-talk from the first channel of the multiplexer due to the received first output signal from the first sensor. Corresponding apparatus. Computer readable storage medium storing instructions for operating the apparatus.

    Abstract translation: 用于处理来自集成电路装置的信号的方法包括传感器阵列和多路复用器，其接收来自传感器阵列的传感器的输出信号。 该方法包括在传感器阵列中的传感器附近启动一个或多个化学反应。 该方法还包括经由多路复用器的第一通道从传感器阵列的第一传感器接收第一输出信号。 该方法还包括经由多路复用器的第二通道从传感器阵列的第二传感器接收第二输出信号。 该方法还包括：由于接收到的来自第一传感器的第一输出信号，计算经调整的第二输出信号以补偿来自多路复用器的第一通道的串扰。 相应设备。 存储用于操作该装置的指令的计算机可读存储介质。

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