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公开(公告)号：WO2010096084A1
公开(公告)日：2010-08-26
申请号：PCT/US2009/053018
申请日：2009-08-06
Applicant: LIFE TECHNOLOGIES CORPORATION , TULSKY, Eric , HALEY, Kari , NAASANI, Imad , MAURO, John, Matthew , ROZHKOV, Roman , TREADWAY, Joeseph, A.
Inventor： TULSKY, Eric , HALEY, Kari , NAASANI, Imad , MAURO, John, Matthew , ROZHKOV, Roman , TREADWAY, Joeseph, A.
CPC classification number: G01N33/588 , B01J13/14 , B22F1/0022 , B22F1/02 , B82Y30/00 , G01N1/30 , G01N21/64 , G01N2001/302 , Y10S977/773 , Y10S977/81 , Y10S977/834 , Y10S977/902
Abstract: Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided.
Abstract translation: 本文提供了制备包含核/壳纳米晶体的水溶性纳米颗粒的方法，所述核/壳纳米晶体涂覆有包含足够的亲水配体的表面层，以使纳米颗粒水溶性或水分散。 还提供了在纳米颗粒表面上交联分子的方法，该方法可用于上述水溶性纳米颗粒。 还提供了由这些方法得到的纳米颗粒组合物。
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公开(公告)号：WO2017196676A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/031403
申请日：2017-05-05
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： WONG, Chiu Tai Andrew , YANG, Xiaoling , SEEGER, Collyn , REARICK, Todd , MENCHEN, Steven , ROZHKOV, Roman , ROSENBLUM, Barnett , GRAHAM, Ronald
IPC: C12Q1/68
CPC classification number: C12Q1/6874 , C12Q2563/137 , C12Q2563/149 , C12Q2565/607
Abstract: The present disclosure provides methods relating to detecting, identifying and measuring nucleic acids that includes binding metal ions to nucleic acid polymer backbones having negative charges formed as a result of nucleotide incorporation, and detecting or measuring hydrogen ions that are generated as a result of forming metal chelate complexes by addition of chelating agents.
Abstract translation: 本公开提供了涉及检测，鉴定和测量核酸的方法，所述方法包括将金属离子结合至具有由于核苷酸掺入而形成负电荷的核酸聚合物骨架，并且检测或测量氢离子 是由于通过添加螯合剂形成金属螯合物而产生的。
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公开(公告)号：WO2014151961A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026735
申请日：2014-03-13
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： LIGHT, David , HINZ, Wolfgang , CICERO, Ronald , INMAN, Christina , KENNEY, Paul , MASTROIANNI, Alexander , ROZHKOV, Roman , WANG, Yufang , GRAY, Jeremy , GLAZER, Marc , GREMYACHINSKIY, Dmitriy
IPC: C12Q1/68
CPC classification number: C12Q1/6837 , C12Q1/6806 , C12Q1/6834 , C12Q2523/101
Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.
Abstract translation: 形成聚合物基质阵列的方法包括将水溶液施加到阱阵列的孔中。 该水溶液包括聚合物前体。 该方法还包括在井阵列上施加不混溶流体以将井阵列中的水溶液隔离并聚合在井阵列的孔中分离的聚合物前体以形成聚合物基质阵列。 一种装置包括传感器阵列，对应于传感器阵列的阱阵列，以及设置在阱阵列中的聚合物阵列阵列。
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公开(公告)号：WO2010039897A2
公开(公告)日：2010-04-08
申请号：PCT/US2009/059117
申请日：2009-09-30
Applicant: LIFE TECHNOLOGIES CORPORATION , TULSKY, Eric , WELCH, Eric , BRANCHAUD, Bruce , ROZHKOV, Roman
Inventor： TULSKY, Eric , WELCH, Eric , BRANCHAUD, Bruce , ROZHKOV, Roman
CPC classification number: C09K11/025 , C09K11/883 , Y10T428/2998
Abstract: Coated fluorescent semiconductor nanoparticles having an organic surface layer of multi-functional surface ligands that include a nanocrystal binding center and one or more covalently attached functional groups or reactive functional groups are described as well as water-dispersible nanoparticles having an organic surface layer or multi-functional surface ligands and methods for the preparation and use of such coated nanoparticles.
Abstract translation: 描述了具有包含纳米晶体结合中心和一个或多个共价连接的官能团或反应性官能团的多官能表面配体的有机表面层的涂覆的荧光半导体纳米粒子以及水分散性纳米粒子 具有有机表面层或多功能表面配体以及用于制备和使用这种涂覆的纳米颗粒的方法。
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公开(公告)号：EP3249057A1
公开(公告)日：2017-11-29
申请号：EP17181624.2
申请日：2014-03-13
Applicant: Life Technologies Corporation
Inventor： LIGHT, David , HINZ, Wofgang , CICERO, Ronald , INMAN, Christina , KENNEY, Paul , MASTROIANNI, Alexander , ROZHKOV, Roman , WANG, Yufang , GRAY, Jeremy , GLAZER, Marc , GREMYACHINSKIY, Dmitriy
IPC: C12Q1/68
CPC classification number: C12Q1/6837 , C12Q1/6806 , C12Q1/6834 , C12Q1/6869 , C12Q2523/101 , C12Q2527/119 , C12Q2535/122 , C12Q2547/107 , C12Q2563/159 , C12Q2565/537 , C12Q2523/301 , C12Q2523/32
Abstract: A method of forming a polymer matrix array includes applying an aqueous solution into wells of a well array. The aqueous solution includes polymer precursors. The method further includes applying an immiscible fluid over the well array to isolate the aqueous solution within the wells of the well array and polymerizing the polymer precursors isolated in the wells of the well array to form the polymer matrix array. An apparatus includes a sensor array, a well array corresponding to the sensor array, and an array of polymer matrices disposed in the well array.
Abstract translation: 形成聚合物基质阵列的方法包括将水溶液施加到孔阵列的孔中。 水溶液包含聚合物前体。 该方法进一步包括在井阵列上施加不混溶流体以隔离井阵列的井内的水溶液，并聚合在井阵列的井中分离的聚合物前体以形成聚合物基质阵列。 一种装置包括传感器阵列，对应于传感器阵列的井阵列以及布置在井阵列中的聚合物矩阵的阵列。
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Patent Agency Ranking
公开(公告)号：EP3249057B1
公开(公告)日：2019-05-01
申请号：EP17181624.2
申请日：2014-03-13
Applicant: Life Technologies Corporation
Inventor： LIGHT, David , HINZ, Wofgang , CICERO, Ronald , INMAN, Christina , KENNEY, Paul , MASTROIANNI, Alexander , ROZHKOV, Roman , WANG, Yufang , GRAY, Jeremy , GLAZER, Marc , GREMYACHINSKIY, Dmitriy
IPC: C12Q1/68
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公开(公告)号：EP2971089B1
公开(公告)日：2017-07-19
申请号：EP14716714.2
申请日：2014-03-13
Applicant: Life Technologies Corporation
Inventor： LIGHT, David , HINZ, Wolfgang , CICERO, Ronald , INMAN, Christina , KENNEY, Paul , MASTROIANNI, Alexander , ROZHKOV, Roman , WANG, Yufang , GRAY, Jeremy , GLAZER, Marc , GREMYACHINSKIY, Dmitriy
IPC: C12Q1/68
CPC classification number: C12Q1/6837 , C12Q1/6806 , C12Q1/6834 , C12Q2523/101
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公开(公告)号：EP2323947A1
公开(公告)日：2011-05-25
申请号：EP09840552.5
申请日：2009-08-06
Applicant: Life Technologies Corporation
Inventor： TULSKY, Eric , HALEY, Kari , NAASANI, Imad , MAURO, John, Matthew , ROZHKOV, Roman , TREADWAY, Joeseph, A.
CPC classification number: G01N33/588 , B01J13/14 , B22F1/0022 , B22F1/02 , B82Y30/00 , G01N1/30 , G01N21/64 , G01N2001/302 , Y10S977/773 , Y10S977/81 , Y10S977/834 , Y10S977/902
Abstract: Provided herein are methods for making water-soluble nanoparticles comprising a core/shell nanocrystal that is coated with a surface layer comprising enough hydrophilic ligands to render the nanoparticle water soluble or water dispersable. Methods for crosslinking molecules on the surface of a nanoparticle, which methods can be used on the above water-soluble nanoparticles also are provided. Nanoparticle compositions resulting from these methods are also provided.
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公开(公告)号：EP2323947B1
公开(公告)日：2019-07-03
申请号：EP09840552.5
申请日：2009-08-06
Applicant: Life Technologies Corporation
Inventor： TULSKY, Eric , HALEY, Kari , NAASANI, Imad , MAURO, John, Matthew , ROZHKOV, Roman , TREADWAY, Joeseph, A.
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公开(公告)号：EP2344417B1
公开(公告)日：2017-01-04
申请号：EP09818479.9
申请日：2009-09-30
Applicant: Life Technologies Corporation
Inventor： TULSKY, Eric , WELCH, Eric , BRANCHAUD, Bruce , ROZHKOV, Roman
CPC classification number: C09K11/025 , C09K11/883 , Y10T428/2998
Abstract: Coated fluorescent semiconductor nanoparticles having an organic surface layer of multi-functional surface ligands that include a nanocrystal binding center and one or more covalently attached functional groups or reactive functional groups are described as well as water-dispersible nanoparticles having an organic surface layer or multi-functional surface ligands and methods for the preparation and use of such coated nanoparticles.
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