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    POLYMER PARTICLES, NUCLEIC ACID POLYMER PARTICLES AND METHODS OF MAKING AND USING THE SAME
    2.
    发明申请
    POLYMER PARTICLES, NUCLEIC ACID POLYMER PARTICLES AND METHODS OF MAKING AND USING THE SAME 审中-公开
    聚合物颗粒，核酸聚合物颗粒及其制备和使用方法

    公开(公告)号：WO2013006824A2

    公开(公告)日：2013-01-10

    申请号：PCT/US2012/045827

    申请日：2012-07-06

    Applicant: LIFE TECHNOLOGIES CORPORATION ,  LIGHT, David ,  ROSENBLUM, Barnett

    Inventor： LIGHT, David ,  ROSENBLUM, Barnett

    IPC: C08F2/32 ,  C12Q1/68 ,  C08F220/56 ,  C08F6/00

    CPC classification number: C12Q1/6834 ,  C08F2/32 ,  C08F220/56 ,  C08F222/385 ,  C08F251/00 ,  C12Q1/6869 ,  C12Q2563/155 ,  C12Q2563/159

    Abstract: The disclosure relates to methods of making polymer particles, said methods including the steps of: making an aqueous gel reaction mixture; forming an emulsion having dispersed aqueous phase micelles of gel reaction mixture in a continuous phase; adding an initiator oil comprising at least one polymerization initiator to the continuous phase; and performing a polymerization reaction in the micelles. Further, the initiator oil is present in a volume % relative to a volume of the aqueous gel reaction mixture of between about 1 vol% to about 20 vol%. The disclosure also relates to methods of making nucleic acid polymer particles having the same method steps and wherein the aqueous gel reaction mixture includes a nucleic acid fragment, such as a primer.

    Abstract translation: 本公开涉及制备聚合物颗粒的方法，所述方法包括以下步骤：制备水性凝胶反应混合物; 在连续相中形成具有分散的凝胶反应混合物的水相胶束的乳液; 向所述连续相中加入包含至少一种聚合引发剂的引发剂油; 并在胶束中进行聚合反应。 此外，引发剂油相对于水性凝胶反应混合物的体积的体积％为约1体积％至约20体积％。 本公开还涉及制备具有相同方法步骤的核酸聚合物颗粒的方法，并且其中所述水性凝胶反应混合物包括核酸片段，例如引物。

    POLYMER PARTICLES, NUCLEIC ACID POLYMER PARTICLES AND METHODS OF MAKING AND USING THE SAME
    6.
    发明公开
    POLYMER PARTICLES, NUCLEIC ACID POLYMER PARTICLES AND METHODS OF MAKING AND USING THE SAME 审中-公开
    聚合物，生产和使用核酸聚合物颗粒和方法

    公开(公告)号：EP2729501A2

    公开(公告)日：2014-05-14

    申请号：EP12737440.3

    申请日：2012-07-06

    Applicant: Life Technologies Corporation

    Inventor： LIGHT, David ,  ROSENBLUM, Barnett

    IPC: C08F2/32 ,  C12Q1/68 ,  C08F220/56 ,  C08F6/00

    CPC classification number: C12Q1/6834 ,  C08F2/32 ,  C08F220/56 ,  C08F222/385 ,  C08F251/00 ,  C12Q1/6869 ,  C12Q2563/155 ,  C12Q2563/159

    Abstract: The disclosure relates to methods of making polymer particles, said methods including the steps of: making an aqueous gel reaction mixture; forming an emulsion having dispersed aqueous phase micelles of gel reaction mixture in a continuous phase; adding an initiator oil comprising at least one polymerization initiator to the continuous phase; and performing a polymerization reaction in the micelles. Further, the initiator oil is present in a volume % relative to a volume of the aqueous gel reaction mixture of between about 1 vol % to about 20 vol %. The disclosure also relates to methods of making nucleic acid polymer particles having the same method steps and wherein the aqueous gel reaction mixture includes a nucleic acid fragment, such as a primer.

    Abstract translation: 本发明涉及制备聚合物颗粒的方法，所述包括以下步骤的方法：使在wässrige凝胶反应混合物; 形成的乳液中具有在连续相中分散的凝胶的反应混合物的相wässrige胶束; 加入引发剂油，其包含至少一种聚合引发剂的连续相; 以及执行在胶束进行聚合反应。 此外，引发剂油的存在相对于体积的约1％时，反应混合物wässrige凝胶的体积的体积％到约20体积％。 所以本发明涉及制备具有相同的方法步骤核酸聚合物颗粒的方法和worin的wässrige凝胶反应混合物包括核酸片段，检查作为引物。

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