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    MICROFLUIDIC DEVICES AND METHODS FOR PERFORMING SERUM SEPARATION AND BLOOD CROSS-MATCHING
    4.
    发明申请
    MICROFLUIDIC DEVICES AND METHODS FOR PERFORMING SERUM SEPARATION AND BLOOD CROSS-MATCHING 审中-公开
    微血管装置及其血液分离与血液交叉匹配的方法

    公开(公告)号：US20160109467A1

    公开(公告)日：2016-04-21

    申请号：US14889366

    申请日：2014-05-07

    Applicant: MICRONICS, INC.

    Inventor： Andrew W. Kolb ,  Carolina L. Elmufdi ,  C. Frederick Battrell

    IPC: G01N33/80 ,  B01L3/00

    CPC classification number: G01N33/80 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0883 ,  B01L2400/0406 ,  B01L2400/0481 ,  G01N33/491

    Abstract: Microfluidic cartridges or devices for serum separation and blood cross-match analysis are provided. The devices may include a serum separation subcircuit alone or in combination with a solute mixing subcircuit. The serum separation subcircuit promotes on-cartridge clotting of a blood sample and manipulates the flow of the separated serum sample for subsequent cross-match analysis with a second blood sample, for example. The solute mixing subcircuit includes at least two intake channels, one for a whole blood sample from, for example, a blood donor and the other for the separated serum sample from, for example, a transfusion recipient. The solute mixing subcircuit further includes a serpentine mixing channel conjoined to a downstream channel. Under vacuum generated by a conjoined finger pump, the two input streams fill the serpentine mixing and downstream channels due to capillary action, enabling visualization of an agglutination reaction.

    Abstract translation: 提供用于血清分离和血液交叉匹配分析的微流控盒或装置。 装置可以包括单独的血清分离子电路或者与溶质混合分支电路组合。 血清分离辅助电路促进血液样品的盒式凝血，并操纵分离的血清样品的流动，用于随后与第二血液样品的交叉匹配分析。 溶质混合分支电路包括至少两个进气通道，一个用于来自例如血液供体的全血样品，另一个用于来自例如输血接受者的分离的血清样品。 溶质混合分支电路还包括与下游通道结合的蛇形混合通道。 在由结合的手指泵产生的真空下，两个输入流由于毛细管作用而填充蛇形混合和下游通道，从而使凝集反应可视化。

    Portable fluorescence detection system and microassay cartridge
    6.
    发明授权
    Portable fluorescence detection system and microassay cartridge 有权

    公开(公告)号：US10436713B2

    公开(公告)日：2019-10-08

    申请号：US15804869

    申请日：2017-11-06

    Applicant: Micronics, Inc.

    Inventor： C. Frederick Battrell ,  Troy D. Daiber ,  William Samuel Hunter

    IPC: G01N21/64 ,  B01L3/00 ,  B01L7/00

    Abstract: A compact, microprocessor-controlled instrument for fluorometric assays in liquid samples has a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor controlled by an optical data acquisition and processing daemon within the detector head for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high-gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. The assay ma be validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Molecular biological assays use PCR amplification of target nucleic acids and fluorometric assays, which may require temperature control during detection. Sensitivity and resistance to bubble interference during scanning are improved using a heating block with reflective mirror face in contact with a thermo-optical window enclosing the liquid sample.

    Device for preparation and analysis of nucleic acids
    7.
    发明授权
    Device for preparation and analysis of nucleic acids 有权

    公开(公告)号：US10087440B2

    公开(公告)日：2018-10-02

    申请号：US14889374

    申请日：2014-05-07

    Applicant: Micronics, Inc.

    Inventor： Alan K. Lofquist ,  C. Frederick Battrell ,  Heather K. Bouzek

    IPC: C12N15/10 ,  B01L3/00 ,  C12Q1/6806

    Abstract: An integrated “lab-on-a-chip” microfluidic device performs nucleic acid sample preparation and diagnostic analysis from test samples containing cells and/or particles. The device analyzes DNA or RNA targets, or both, from a common test sample. Dried and/or liquid reagents necessary for nucleic acid sample preparation and analysis are contained on the device, such that the device only requires addition of test sample. Clay mineral and alkaline buffer reagents are employed for overcoming the problems of nucleic acid degradation and contamination during sample preparation. The device may include a composite filter to separate plasma or serum from other blood constituents when the test sample is a blood product. The microfluidic device utilizes a plurality of microfluidic channels, inlets, valves, membranes, pumps, and other elements arranged in various configurations to manipulate the flow of the liquid sample, in particular, in order to prepare nucleic acids and perform further diagnostic analysis.

    PORTABLE FLUORESCENCE DETECTION SYSTEM AND MICROASSAY CARTRIDGE
    9.
    发明申请
    PORTABLE FLUORESCENCE DETECTION SYSTEM AND MICROASSAY CARTRIDGE 审中-公开
    便携式荧光检测系统和MICROASSAY CARTRIDGE

    公开(公告)号：US20150346097A1

    公开(公告)日：2015-12-03

    申请号：US14653726

    申请日：2013-12-20

    Applicant: MICRONICS, INC.

    Inventor： C. Frederick Battrell ,  Troy D. Daiber ,  William Samuel Hunter

    IPC: G01N21/64

    CPC classification number: G01N21/6428 ,  B01L3/502715 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/168 ,  B01L2300/1827 ,  B01L2300/1844 ,  B01L2400/0487 ,  G01N21/645 ,  G01N2201/062 ,  G01N2201/12 ,  Y02A90/26

    Abstract: Disclosed is a compact, microprocessor-controlled instrument for fluorometric assays in liquid samples, the instrument having a floating stage with docking bay for receiving a microfluidic cartridge and a scanning detector head with on-board embedded microprocessor operated under control of a ODAP daemon resident in the detector head for controlling source LEDs, emission signal amplification and filtering in an isolated, low noise, high-gain environment within the detector head. Multiple optical channels may be incorporated in the scanning head. In a preferred configuration, the assay is validated using dual channel optics for monitoring a first fluorophore associated with a target analyte and a second fluorophore associated with a control. Applications include molecular biological assays based on PCR amplification of target nucleic acids and fluorometric assays in general, many of which require temperature control during detection.

    Abstract translation: 公开了一种紧凑的微处理器控制的液体样品中的荧光测定仪器，该仪器具有一个带有用于接收微流控盒的对接托架的浮动台和一个带有板上嵌入式微处理器的扫描检测器， 用于控制源LED的检测器头，在检测器头内的隔离，低噪声，高增益环境中的发射信号放大和滤波。 多个光通道可并入扫描头。 在优选的配置中，使用双通道光学器件验证测定，用于监测与靶分析物相关联的第一荧光团和与对照相关联的第二荧光团。 应用包括基于目标核酸的PCR扩增和荧光测定的分子生物测定法，其中许多在检测期间需要温度控制。

    Microfluidic apparatus and methods for performing blood typing and crossmatching
    10.
    发明授权
    Microfluidic apparatus and methods for performing blood typing and crossmatching 有权
    用于进行血液分型和交配的微流体装置和方法

    公开(公告)号：US09146246B2

    公开(公告)日：2015-09-29

    申请号：US13660834

    申请日：2012-10-25

    Applicant: Micronics, Inc.

    Inventor： C. Frederick Battrell ,  Diane Wierzbicki ,  John Clemmens ,  Jason Capodanno ,  John R. Williford ,  Carolina Elmufdi ,  Isaac Sprague

    IPC: B01L3/00 ,  G01N33/80 ,  G01N33/53

    CPC classification number: G01N33/53 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0627 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2300/161 ,  G01N33/5304 ,  G01N33/80

    Abstract: Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.

    Abstract translation: 提供用于凝集反应的微流控盒。 药筒包括具有至少两个进气通道的微流体反应通道，一个用于含抗原的流体，另一个用于含抗体流体，结合到通过并入下游流动控制通道而修改的反应通道。 在低雷诺数下，两个输入流在反应通道中层叠在另一个之上，并形成流动的，未混合的水平分层的层状流体扩散（HLFD）界面，持续延长的反应时间。 令人惊奇的是，本发明的微流体回路的设计，表面性质和流动状态增强了在分层界面处的抗体介导的凝集的检测。 抗原：涉及通过这些装置增强的凝集的抗体反应可用于血型，输血交配和免疫诊断凝集试验。

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