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    PD-1 and CTLA-4 dual inhibitor peptides
    2.
    发明专利
    PD-1 and CTLA-4 dual inhibitor peptides 未知

    公开(公告)号：AU2018273958A1

    公开(公告)日：2020-01-02

    申请号：AU2018273958

    申请日：2018-05-25

    Applicant: LEIDOS INC

    Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY ,  PANNUCCI JAMES

    IPC: C07K14/705 ,  A61K38/17

    Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PD-L1 as well as the interaction of CTLA4 with CD86 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer; treating infectious diseases; enhancing a response to vaccination; treating sepsis; and promoting hair re-pigmentation or lightening of pigmented skin lesions.

    PD-1 peptide inhibitors
    4.
    发明专利
    PD-1 peptide inhibitors 未知

    公开(公告)号：AU2017325866B2

    公开(公告)日：2021-09-09

    申请号：AU2017325866

    申请日：2017-09-15

    Applicant: LEIDOS INC

    Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

    IPC: C07K7/08 ,  A61K38/10 ,  A61P31/00 ,  A61P35/00

    Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

    PD-1 PEPTIDE INHIBITORS
    6.
    发明专利
    PD-1 PEPTIDE INHIBITORS 未知

    公开(公告)号：CA3036251A1

    公开(公告)日：2018-03-22

    申请号：CA3036251

    申请日：2017-09-15

    Applicant: LEIDOS INC

    Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PANNUCCI JAMES ,  AYALA RAMSES

    IPC: A61K38/10 ,  A61P31/00 ,  A61P35/00 ,  C07K7/08

    Abstract: This disclosure provides peptides which have a strong affinity for the checkpoint receptor "programmed death 1" (PD-1). These peptides block the interaction of PD-1 with its ligand PDL1 and can therefore be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, treating infectious diseases, enhancing a response to vaccination, and treating sepsis.

    LAG 3 binding peptides
    7.
    发明专利
    LAG 3 binding peptides 未知

    公开(公告)号：AU2020279371A1

    公开(公告)日：2021-12-23

    申请号：AU2020279371

    申请日：2020-05-21

    Applicant: LEIDOS INC

    Inventor： GUTIERREZ GABRIEL M ,  KOTRAIAH VINAYAKA ,  PHARES TIMOTHY W ,  PANNUCCI JAMES ,  MANSOUR MARC

    IPC: A61P35/00 ,  A61P25/28 ,  C07K7/00

    Abstract: This disclosure provides peptides which bind to LAG3 and can be used to block the interaction of LAG 3 with other molecules such as MHC-II, FGL1, and α-synuclein. These peptides can be used for various therapeutic purposes, such as inhibiting the progression of a hyperproliferative disorder, including cancer, or inhibiting the progression of a synucleinopathy, inhibiting the progression of sepsis, inhibiting the progression of an infectious disease, and enhancing a response to a vaccine.

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