公开(公告)号：BRPI0214872B1

公开(公告)日：2016-12-13

申请号：BRPI0214872

申请日：2002-12-11

Applicant: STICHTING TECH WETENSCHAPP

Inventor： PRUIJN GERARDUS JOZEF MARIA ,  DRIJFHOUT JAN WOUTER ,  BOEKEL MARTINUS ADRIANUS MARIA VAN ,  VENROOIJ WALTHERUS JACOBUS WILHELMUS VAN

IPC: C07K14/47 ,  C07K7/06 ,  C07K7/08 ,  C07K7/54 ,  G01N33/53 ,  G01N33/564 ,  G01N33/68

Abstract: "métodos de detectar auto-anticorpos de pacientes sofrendo de artrite rumatóide, peptídeo e kit de ensaio". a presente invenção refere-se ao método de detectar auto-anticorpos de pacientes sofrendo de artrite reumatóide. para esta finalidade, de acordo com a invenção, pelo menos duas unidades peptídicas são usadas, das quais pelo menos uma unidade peptídica compreende uma parte não derivada de (pro)filagrina, fibrina, fibrinogênio, vimentina, citoceratina 1 e citoceratina 9, e unidade peptídica esta que compreende o motivo xg, e uma unidade peptídica compreendendo o motivo xnong, em que x é uma citrulina ou um análogo da mesma, e nong é um aminoácido diferente da glicina.

公开(公告)号：PT941244E

公开(公告)日：2007-02-28

申请号：PT97912577

申请日：1997-11-14

Applicant: STICHTING TECH WETENSCHAPP

Inventor： VENROOIJ WALTHERUS JACOBUS WILHELMUS VAN ,  SCHELLEKENS GERARDUS ANTONIUS ,  RAATS JOZEF MARIA HENDRIK ,  HOET RENE MICHAEL ANTONIUS

IPC: C07K14/47 ,  C07K7/08 ,  C07K16/18 ,  C12P21/00 ,  C12P21/08 ,  G01N33/564 ,  G01N33/68

公开(公告)号：AU2010200648A1

公开(公告)日：2010-03-11

申请号：AU2010200648

申请日：2010-02-22

Applicant: STICHTING TECH WETENSCHAPP

Inventor： DRIJFHOUT JAN WOUTER ,  PRUIJIN GERARDUS JOZEF MARIA ,  BOEKEL MARTINUS ADRIANUS MARIA VAN ,  VENROOIJ WALTHERUS JACOBUS WILHELMUS VAN

IPC: G01N33/564 ,  C07K7/06 ,  C07K7/08 ,  C07K7/54 ,  C07K7/64 ,  C07K14/47 ,  G01N33/53

Abstract: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glycine.

公开(公告)号：HK1128329A1

公开(公告)日：2009-10-23

申请号：HK09105983

申请日：2009-07-03

Applicant: STICHTING TECH WETENSCHAPP

Inventor： VENROOIJ WALTHERUS JACOBUS WILHELMUS VAN ,  DRIJFHOUT JAN WOUTER ,  BOEKEL MARTINUS ADRIANUS MARIA VAN ,  PRUIJN GERARDUS JOZEF MARIA

IPC: G01N20060101 ,  C07K20060101 ,  C07K7/06 ,  C07K7/08 ,  C07K7/54 ,  C07K14/47 ,  G01N33/53 ,  G01N33/564

Abstract: The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)fillaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrullin or an analogue thereof, and nonG is an amino acid other than glycine.