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公开(公告)号：IL316462A
公开(公告)日：2024-12-01
申请号：IL31646224
申请日：2024-10-21
Applicant: VERTEX PHARMA , MILLER MARK THOMAS , HURLEY DENNIS JAMES , NEUBERT TIMOTHY DONALD , ARUMUGAM VIJAYALAKSMI , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , ZHOU JINGLAN , CHAU JACLYN , DEMORET ROBERT MARTIN , GHIRMAI SENAIT G , VALIULIN ROMAN ASKATOVICH , KINTZER ALEXANDER FREDERIK , SLOCHOWER DAVID ROBERT , AERTGEERTS KATHLEEN , BECK ELIZABETH MARY , MUI JAMES JUN BON , WRIGHT MIRANDA ADELE , KNEGTEL RONALD MARCELLUS ALPHONSUS , CHUDYK EWA IWONA , PINDER JOANNE LOUISE , DODD JAMES , SIMPSON IAIN
Inventor： MILLER MARK THOMAS , HURLEY DENNIS JAMES , NEUBERT TIMOTHY DONALD , ARUMUGAM VIJAYALAKSMI , HADIDA RUAH SARA SABINA , MCCARTNEY JASON , ZHOU JINGLAN , CHAU JACLYN , DEMORET ROBERT MARTIN , GHIRMAI SENAIT G , VALIULIN ROMAN ASKATOVICH , KINTZER ALEXANDER FREDERIK , SLOCHOWER DAVID ROBERT , AERTGEERTS KATHLEEN , BECK ELIZABETH MARY , MUI JAMES JUN BON , WRIGHT MIRANDA ADELE , KNEGTEL RONALD MARCELLUS ALPHONSUS , CHUDYK EWA IWONA , PINDER JOANNE LOUISE , DODD JAMES , SIMPSON IAIN
Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
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公开(公告)号：SG11202006701TA
公开(公告)日：2020-08-28
申请号：SG11202006701T
申请日：2019-01-28
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BAYLY ANDREW , BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DODD JAMES , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KELLY SHAZIA , KNEGTEL RONALD , MOCHALKIN IGOR , MORTIMORE MICHAEL , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , RUTHERFORD ALISTAIR , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: A61K31/495 , A61K31/505 , A61K31/519 , C07D487/00 , C07D487/02 , C07D487/04
Abstract: The present invention provides compounds inhibiting General amino acid Control Non-derepressible 2 kinase (“GCN2”), compositions thereof, and methods of using the same for treating various disorders, such as cancer.
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公开(公告)号：HK1215256A1
公开(公告)日：2016-08-19
申请号：HK16103327
申请日：2016-03-22
Applicant: VERTEX PHARMA
Inventor： BOYALL DEAN , DAVIS CHRISTOPHER , DODD JAMES , EVERITT SIMON , MILLER ANDREW , WEBER PETER , WESTCOTT JAMES , YOUNG STEPHEN , SETTIMO LUCA
IPC: C07D20060101 , A61K20060101 , A61P20060101
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公开(公告)号：AU2013348167A1
公开(公告)日：2015-05-28
申请号：AU2013348167
申请日：2013-11-19
Applicant: VERTEX PHARMA
Inventor： BOYALL DEAN , DAVIS CHRISTOPHER , DODD JAMES , EVERITT SIMON , MILLER ANDREW , WEBER PETER , WESTCOTT JAMES , YOUNG STEPHEN , SETTIMO LUCA
IPC: C07D403/12 , A61K31/4192 , A61P35/00 , C07D249/10 , C07D401/12 , C07D413/12
Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications.. The compounds of this invention have formula I-A; wherein the variables are as defined herein.
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公开(公告)号：AU2019211485B2
公开(公告)日：2025-01-23
申请号：AU2019211485
申请日：2019-01-28
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BAYLY ANDREW , BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DODD JAMES , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KELLY SHAZIA , KNEGTEL RONALD , MOCHALKIN IGOR , MORTIMORE MICHAEL , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , RUTHERFORD ALISTAIR , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: A61K31/495 , A61K31/505 , A61K31/519 , C07D487/00 , C07D487/02 , C07D487/04
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
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Patent Agency Ranking
公开(公告)号：CA2891412A1
公开(公告)日：2014-05-30
申请号：CA2891412
申请日：2013-11-19
Applicant: VERTEX PHARMA
Inventor： BOYALL DEAN , DAVIS CHRISTOPHER , DODD JAMES , EVERITT SIMON , MILLER ANDREW , WEBER PETER , WESTCOTT JAMES , YOUNG STEPHEN
IPC: C07D403/12 , A61K31/4192 , A61P35/00 , C07D249/10 , C07D401/12 , C07D413/12
Abstract: The present invention relates to compounds useful as inhibitors of indoleamine 2,3-dioxygenase (IDO). The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications.. The compounds of this invention have formula I-A; wherein the variables are as defined herein.
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公开(公告)号：AU2025200232A1
公开(公告)日：2025-02-13
申请号：AU2025200232
申请日：2025-01-13
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BAYLY ANDREW , BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DODD JAMES , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KELLY SHAZIA , KNEGTEL RONALD , MOCHALKIN IGOR , MORTIMORE MICHAEL , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , RUTHERFORD ALISTAIR , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: C07D487/04 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/5383 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/662 , A61P35/00 , C07D487/00 , C07D487/02
Abstract: Abstract Disclosed are heterocyclic compounds as inhibitors of General amino acid control Non-depressible-2 (GCN2) and their use in the treatment of diseases such as cancers.
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公开(公告)号：CO2024015820A2
公开(公告)日：2024-11-28
申请号：CO2024015820
申请日：2024-11-21
Applicant: VERTEX PHARMA
Inventor： HADIDA RUAH SARA SABINA , MCCARTNEY JASON , MILLER MARK THOMAS , ZHOU JINGLAN , ARUMUGAM VIJAYALAKSMI , CHUDYK EWA IWONA , HURLEY DENNIS JAMES , NEUBERT TIMOTHY DONALD , PINDER JOANNE LOUISE , DODD JAMES , CHAU JACLYN , DEMORET ROBERT MARTIN , GHIRMAI SENAIT G , VALIULIN ROMAN ASKATOVICH , KINTZER ALEXANDER FREDERIK , SLOCHOWER DAVID ROBERT , AERTGEERTS KATHLEEN , BECK ELIZABETH MARY , MUI JAMES JUN BON , WRIGHT MIRANDA ADELE , KNEGTEL RONALD MARCELLUS ALPHONSUS , SIMPSON IAIN
IPC: A61P9/06 , A61K31/4375 , A61K31/4709 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/541 , A61K31/55 , A61K31/553 , A61P25/02 , A61P29/00 , C07D215/233 , C07D239/91 , C07D401/04 , C07D401/14 , C07D405/14 , C07D471/04 , C07D519/00
Abstract: Se proporcionan compuestos, y sales farmacéuticamente aceptables de estos, útiles como inhibidores de canales de sodio. También se proporcionan composiciones farmacéuticas que comprenden los compuestos o sales farmacéuticamente aceptables y métodos de uso de los compuestos, sales farmacéuticamente aceptables y composiciones farmacéuticas en el tratamiento de diversos trastornos, incluido el dolor.
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公开(公告)号：AU2019211485A1
公开(公告)日：2020-08-06
申请号：AU2019211485
申请日：2019-01-28
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BAYLY ANDREW , BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DODD JAMES , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KELLY SHAZIA , KNEGTEL RONALD , MOCHALKIN IGOR , MORTIMORE MICHAEL , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , RUTHERFORD ALISTAIR , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: A61K31/495 , A61K31/505 , A61K31/519 , C07D487/00 , C07D487/02 , C07D487/04
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
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公开(公告)号：CA3089762A1
公开(公告)日：2019-08-01
申请号：CA3089762
申请日：2019-01-28
Applicant: MERCK PATENT GMBH , VERTEX PHARMA
Inventor： BAYLY ANDREW , BLEICH MATTHEW , CHARRIER JEAN-DAMIEN , DODD JAMES , DURRANT STEVEN , ENO MEREDITH SUZANNE , ETXEBARRIA I JARDI GORKA , EVERITT SIMON , FRAYSSE DAMIEN , KELLY SHAZIA , KNEGTEL RONALD , MOCHALKIN IGOR , MORTIMORE MICHAEL , NORTH KIRI , PORICHIS FILIPPOS , PULLIN ROBERT , RUTHERFORD ALISTAIR , STORCK PIERRE-HENRI , TWIN HEATHER CLARE , XIAO YUFANG
IPC: C07D487/04 , A61K31/395 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61P35/00 , C07D519/00
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
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