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    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE
    1.
    发明申请
    COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE 审中-公开
    化合物作为ATR激酶的抑制剂有用

    公开(公告)号：WO2011143425A3

    公开(公告)日：2012-02-23

    申请号：PCT/US2011036245

    申请日：2011-05-12

    Applicant: VERTEX PHARMA ,  CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN JOHN ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  VIRANI ANIZA NIZARALI ,  REAPER PHILIP MICHAEL

    Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN JOHN ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  VIRANI ANIZA NIZARALI ,  REAPER PHILIP MICHAEL

    IPC: C07D239/46 ,  C07D413/04

    CPC classification number: A61K31/4965 ,  A61K31/497 ,  A61K33/24 ,  C07D239/46 ,  C07D241/24 ,  C07D413/04

    Abstract: The present invention relates to pyrazine and pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (IV): (Formula (IV)) wherein the variables are as defined herein.

    Abstract translation: 本发明涉及可用作ATR蛋白激酶抑制剂的吡嗪和吡啶化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用化合物的方法，如生物和病理现象中激酶的研究; 由这种激酶介导的细胞内信号转导途径的研究; 和新型激酶抑制剂的比较评估。 本发明的化合物具有式（IV）：（式（IV）），其中变量如本文所定义。

    2 -aminopyridine derivatives useful as inhibitors of ATR kinase
    5.
    发明专利
    2 -aminopyridine derivatives useful as inhibitors of ATR kinase 未知

    公开(公告)号：AU2011253021A1

    公开(公告)日：2012-11-29

    申请号：AU2011253021

    申请日：2011-05-12

    Applicant: VERTEX PHARMA

    Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN JOHN ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  REAPER PHILIP MICHAEL

    IPC: C07D213/82 ,  A61K31/4439 ,  A61P35/00 ,  C07D413/04 ,  C07D413/14

    Abstract: The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (III): (Formula (III) wherein the variables are as defined herein.

    2-AMINOPYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE
    6.
    发明专利
    2-AMINOPYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE 未知

    公开(公告)号：CA2798760A1

    公开(公告)日：2011-11-17

    申请号：CA2798760

    申请日：2011-05-12

    Applicant: VERTEX PHARMA

    Inventor： CHARRIER JEAN-DAMIEN ,  DURRANT STEVEN JOHN ,  KNEGTEL RONALD MARCELLUS ALPHONSUS ,  REAPER PHILIP MICHAEL

    IPC: C07D213/82 ,  A61K31/4439 ,  A61P35/00 ,  C07D413/04 ,  C07D413/14

    Abstract: The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (III): (Formula (III) wherein the variables are as defined herein.

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