公开(公告)号：ZA200507979B

公开(公告)日：2007-03-28

申请号：ZA200507979

申请日：2004-03-03

Applicant: VERTEX PHARMA INC

Inventor： GONZALES III JESUS E ,  MITCHELL WILSON DEAN ,  PETER TERMIN ANDREAS ,  GROOTENHUIS PETER DIEDERIK JAN ,  YULIAN ZHANG ,  JOHN PETZOLDT BENJAMAIN ,  DEWEY FANNING LEV TYLER ,  DONALD NEUBERT TIMOTHY ,  TUNG ROGER D ,  ESTHER MARTINBOUROUGH ,  NICOLE ZIMMERMANN

IPC: A61K20090101 ,  C07D20090101

公开(公告)号：AU2004217891B2

公开(公告)日：2011-06-23

申请号：AU2004217891

申请日：2004-03-03

Applicant: VERTEX PHARMA

Inventor： DEWEY FANNING LEV TYLER ,  TUNG ROGER D ,  YULIAN ZHANG ,  GONZALES JESUS E III ,  PETER TERMIN ANDREAS ,  DONALD NEUBERT TIMOTHY ,  ESTHER MARTINBOROUGH ,  JOHN PETZOLDT BENJAMIN ,  JAN GROOTENHUIS PETER DIEDERIK ,  MITCHELL WILSON DEAN ,  NICOLE ZIMMERMANN

IPC: C07D239/94 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D20060101 ,  C07D239/91 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R, X, R, x, and ring A are as defined in the present application.

公开(公告)号：ZA200601859B

公开(公告)日：2008-03-26

申请号：ZA200601859

申请日：2004-08-05

Applicant: VERTEX PHARMA

Inventor： JIAN WANG ,  YULIAN ZHANG ,  GONZALEZ III JESUS E ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMANN ,  WILSON DEAN M ,  PETER TERMIN ANDREAS ,  DONALD NEUBERT TIMOTHY

IPC: A61K20090101 ,  A61K31/517 ,  A61K31/5377 ,  A61P20090101 ,  A61P25/00 ,  A61P29/00 ,  C07D20090101 ,  C07D239/70 ,  C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D413/02 ,  C07D471/04 ,  C07D495/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：UY28402A1

公开(公告)日：2005-01-31

申请号：UY28402

申请日：2004-07-02

Applicant: VERTEX PHARMA

Inventor： NICOLE ZIMMERMANN ,  III GONZALEZ JESUS E ,  ESTHER MARTINBOROUGH ,  DONALD NEUBERT TIMOTHY ,  PETER TERMIN ANDREAS ,  MITCHELL WILSON DEAN

IPC: C07D239/00

Abstract: La presente invención se refiere a compuestos útiles como inhibidores de canales de sodio regulados por voltaje. La invención también porporciona composiciones farmacéuticamente aceptables que comprenden los compuetos de la invención y métodos para usar las composiciones en el tratamiento de diversos trastornos.