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公开(公告)号：WO2005022113A3
公开(公告)日：2005-05-19
申请号：PCT/US2004022047
申请日：2004-07-08
Applicant: VERTEX PHARMA , MAHER MICHAEL P , GONZALEZ III JESUS E
Inventor： MAHER MICHAEL P , GONZALEZ III JESUS E
IPC: G01N33/487 , G01N33/50 , G01N33/68 , C12N15/00 , C12N15/63 , G01N25/18 , G01N33/566
CPC classification number: G01N33/5038 , G01N33/48728 , G01N33/5008 , G01N33/5076 , G01N33/5088 , G01N33/542 , G01N33/6872
Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
Abstract translation: 表征候选化合物的生物活性的方法可以包括将细胞暴露于候选化合物，然后将细胞暴露于电场的重复施用，以将跨膜电位设定为与预选电压相关的水平 目标离子通道的状态。
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公开(公告)号：EP1644497A4
公开(公告)日：2007-08-08
申请号：EP04801966
申请日：2004-07-08
Applicant: VERTEX PHARMA
Inventor： MAHER MICHAEL P , GONZALEZ III JESUS E
IPC: C12N15/00 , C12N15/63 , G01N25/18 , G01N33/487 , G01N33/50 , G01N33/566 , G01N33/68
CPC classification number: G01N33/5038 , G01N33/48728 , G01N33/5008 , G01N33/5076 , G01N33/5088 , G01N33/542 , G01N33/6872
Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
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公开(公告)号：AU2009212941B2
公开(公告)日：2012-06-28
申请号：AU2009212941
申请日：2009-09-04
Applicant: VERTEX PHARMA SAN DIEGO LLC
Inventor： MAHER MICHAEL P , GONZALEZ III JESUS E
IPC: G01N21/64 , C12Q1/02 , G01N21/78 , G01N27/416 , G01N33/00 , G01N33/15 , G01N33/50 , G01N33/68 , G01N37/00
Abstract: A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
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公开(公告)号：AU2010246565B2
公开(公告)日：2011-11-24
申请号：AU2010246565
申请日：2010-12-01
Applicant: VERTEX PHARMA
Inventor： MAHER MICHAEL P , GONZALEZ III JESUS E
IPC: G01N33/487 , G01N33/50 , G01N33/68
Abstract: Abstract of the Disclosure A method of characterizing the biological activity of a candidate compound may include exposing cells to the candidate compound, and then exposing the cells to a 5 repetitive application of electric fields so as to set the transmembrane potential to a level corresponding to a pre-selected voltage dependent state of a target ion channel.
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公开(公告)号：AU2004269322B2
公开(公告)日：2010-09-02
申请号：AU2004269322
申请日：2004-07-08
Applicant: VERTEX PHARMA
Inventor： GONZALEZ III JESUS E , MAHER MICHAEL P
IPC: G01N33/487 , G01N33/50 , G01N33/68
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Patent Agency Ranking
公开(公告)号：PE03552005A1
公开(公告)日：2005-05-16
申请号：PE0007612004
申请日：2004-08-05
Applicant: VERTEX PHARMA
Inventor： TERMIN ANDREAS P , ZHANG YULIAN , GONZALEZ III JESUS E , ZIMMERMAN NICOLE , WANG JIAN , WILSON DEAN M , NEUBERT TIMOTHY D , MARTINBOROUGH ESTHER
IPC: A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04
CPC classification number: C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
Abstract: REFERIDA A UN COMPUESTO DE FORMULA I O A UNA DE SUS SALES DONDE p ES 0-2; X1, X2, X3 Y X4 SON CADA UNO C=O, S, O, ENTRE OTROS; R1 Y R2 SON CADA UNO, H, UN GRUPO ALIFATICO C1-C6; ARILO DE 5-6 MIEMBROS, ENTRE OTROS; A ES ANILLO MONOCICLICO DE 5-6 MIEMBROS O BICICLICO DE 8-10 MIEMBROS, ANILLO SATURADO DE 3-7 MIEMBROS, ENTRE OTROS. ADICIONALMENTE, ESTOS COMPUESTOS RESULTANTES QUE SON UTILES COMO INHIBIDORES DE LOS CANALES DE SODIO REGULADOS POR VOLTAJE FORMAN COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE DOLOR AGUDO, ARTRITIS, EPILEPSIA, ENTRE OTROS
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公开(公告)号：AU2004269322A1
公开(公告)日：2005-03-10
申请号：AU2004269322
申请日：2004-07-08
Applicant: VERTEX PHARMA
Inventor： GONZALEZ III JESUS E , MAHER MICHAEL P
IPC: C12N15/00 , C12N15/63 , G01N25/18 , G01N33/487 , G01N33/50 , G01N33/566 , G01N33/68
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公开(公告)号：PE20050355A1
公开(公告)日：2005-05-16
申请号：PE2004000761
申请日：2004-08-05
Applicant: VERTEX PHARMA
Inventor： TERMIN ANDREAS P , ZHANG YULIAN , GONZALEZ III JESUS E , ZIMMERMAN NICOLE , WANG JIAN , WILSON DEAN M , NEUBERT TIMOTHY D , MARTINBOROUGH ESTHER
IPC: A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04
Abstract: REFERIDA A UN COMPUESTO DE FORMULA I O A UNA DE SUS SALES DONDE p ES 0-2; X1, X2, X3 Y X4 SON CADA UNO C=O, S, O, ENTRE OTROS; R1 Y R2 SON CADA UNO, H, UN GRUPO ALIFATICO C1-C6; ARILO DE 5-6 MIEMBROS, ENTRE OTROS; A ES ANILLO MONOCICLICO DE 5-6 MIEMBROS O BICICLICO DE 8-10 MIEMBROS, ANILLO SATURADO DE 3-7 MIEMBROS, ENTRE OTROS. ADICIONALMENTE, ESTOS COMPUESTOS RESULTANTES QUE SON UTILES COMO INHIBIDORES DE LOS CANALES DE SODIO REGULADOS POR VOLTAJE FORMAN COMPOSICIONES FARMACEUTICAS PARA EL TRATAMIENTO DE DOLOR AGUDO, ARTRITIS, EPILEPSIA, ENTRE OTROS
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公开(公告)号：PE03582005A1
公开(公告)日：2005-05-16
申请号：PE0007742004
申请日：2004-08-09
Applicant: VERTEX PHARMA
Inventor： TERMIN ANDREAS P , MARTINBOROUGH ESTHER , GONZALEZ III JESUS E , ZIMMERMAN NICOLE
IPC: A61K31/513 , A61K31/517 , A61K31/522 , A61K31/5377 , A61K31/5415 , C07C311/46 , C07C311/51 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/46 , C07D239/52 , C07D239/54 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04 , A61K7/00
CPC classification number: C07D417/14 , C04B35/632 , C07C311/46 , C07C311/51 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D209/80 , C07D209/92 , C07D213/76 , C07D231/38 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/52 , C07D239/545 , C07D239/69 , C07D241/22 , C07D261/16 , C07D263/50 , C07D277/52 , C07D277/82 , C07D285/125 , C07D285/135 , C07D295/26 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
Abstract: REFERIDA A UN COMPUESTO DE FORMULA I-A DONDE RN ES H, C1-C4 ALIIFATICO OPCIONALMENTE SUSTITUIDO; X1 ES O, S O NRX; X2 ES C1-C3 ALIFATICO OPCIONALMENTE SUSTITUIDO; p ES 0-1; Z ES i, ii, ENTRE OTROS; T ES ANILLO BICICLICO O TRICICLICO, AROMATICO O NO, DE 8-14 MIEMBROS TAL COMO NAFTILO, TETRALINA, O DECALINA. SON COMPUESTOS PREFERIDOS: 4-(2,4-DICLOROFENOXI)-BUTIRATO DE ETILO; 5,7-DICLORO-INDOL-2-IL-N-[4-(TIADIAZOL-2-ILSULFAMOIL)-FENIL]AMIDA Y N-[4-(TIAZOL-2-ILSULFAMOIL)-FENIL]-2-(4-FLUOROFENOXI)-ACETAMIDA; ENTRE OTROS. TAMBIEN REFERIDO A COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN DICHOS COMPUESTOS QUE SON UTILES PARA EL TRATAMIENTO DE DOLORES NEUROPATICOS E INTRATABLES
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公开(公告)号：AU2011250764A1
公开(公告)日：2011-12-08
申请号：AU2011250764
申请日：2011-11-14
Applicant: VERTEX PHARMA
Inventor： WILSON DEAN M , TERMIN ANDREAS P , NEUBERT TIMOTHY D , ESTHER MARTINBOROUGH , JIAN WANG , YULIAN ZHANG , NICOLE ZIMMERMANN , GONZALEZ III JESUS E
IPC: C07D471/04 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D495/04
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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