公开(公告)号：AT548358T

公开(公告)日：2012-03-15

申请号：AT04780401

申请日：2004-08-05

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN ,  TERMIN ANDREAS ,  NEUBERT TIMOTHY ,  JIAN WANG ,  YULIAN ZHANG ,  JESUS E GONZALEZ III ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMANN

IPC: C07D239/94 ,  A61K31/517 ,  A61K31/5377 ,  A61P25/00 ,  A61P29/00 ,  C07D239/70 ,  C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D413/02 ,  C07D471/04 ,  C07D495/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：ZA200507979B

公开(公告)日：2007-03-28

申请号：ZA200507979

申请日：2004-03-03

Applicant: VERTEX PHARMA INC

Inventor： GONZALES III JESUS E ,  MITCHELL WILSON DEAN ,  PETER TERMIN ANDREAS ,  GROOTENHUIS PETER DIEDERIK JAN ,  YULIAN ZHANG ,  JOHN PETZOLDT BENJAMAIN ,  DEWEY FANNING LEV TYLER ,  DONALD NEUBERT TIMOTHY ,  TUNG ROGER D ,  ESTHER MARTINBOUROUGH ,  NICOLE ZIMMERMANN

IPC: A61K20090101 ,  C07D20090101

公开(公告)号：ZA200603864B

公开(公告)日：2007-09-26

申请号：ZA200603864

申请日：2004-10-28

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  GONZALEZ JESUS E III ,  NICOLE ZIMMERMANN ,  YULIAN ZHANG ,  FANNING LEV T D

IPC: A61K20090101 ,  A61K31/33 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/454 ,  C07D20090101 ,  C07D209/14 ,  C07D209/42 ,  C07D235/06 ,  C07D235/10 ,  C07D235/14 ,  C07D235/18 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

Abstract: The present invention relates to compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein the R1, Z, Y, RA, and W groups of formula I are as defined herein. The invention also provides pharmaceutically acceptable compositions and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2011250764A1

公开(公告)日：2011-12-08

申请号：AU2011250764

申请日：2011-11-14

Applicant: VERTEX PHARMA

Inventor： WILSON DEAN M ,  TERMIN ANDREAS P ,  NEUBERT TIMOTHY D ,  ESTHER MARTINBOROUGH ,  JIAN WANG ,  YULIAN ZHANG ,  NICOLE ZIMMERMANN ,  GONZALEZ III JESUS E

IPC: C07D471/04 ,  A61P25/00 ,  A61P29/00 ,  C07D239/70 ,  C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D495/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

公开(公告)号：AU2004217891B2

公开(公告)日：2011-06-23

申请号：AU2004217891

申请日：2004-03-03

Applicant: VERTEX PHARMA

Inventor： DEWEY FANNING LEV TYLER ,  TUNG ROGER D ,  YULIAN ZHANG ,  GONZALES JESUS E III ,  PETER TERMIN ANDREAS ,  DONALD NEUBERT TIMOTHY ,  ESTHER MARTINBOROUGH ,  JOHN PETZOLDT BENJAMIN ,  JAN GROOTENHUIS PETER DIEDERIK ,  MITCHELL WILSON DEAN ,  NICOLE ZIMMERMANN

IPC: C07D239/94 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D20060101 ,  C07D239/91 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/02 ,  C07D413/12 ,  C07D417/02 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present invention relates to quinazoline compounds of formula (I) useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. or a pharmaceutically acceptable derivative thereof, wherein R, X, R, x, and ring A are as defined in the present application.

公开(公告)号：ZA200601859B

公开(公告)日：2008-03-26

申请号：ZA200601859

申请日：2004-08-05

Applicant: VERTEX PHARMA

Inventor： JIAN WANG ,  YULIAN ZHANG ,  GONZALEZ III JESUS E ,  ESTHER MARTINBOROUGH ,  NICOLE ZIMMERMANN ,  WILSON DEAN M ,  PETER TERMIN ANDREAS ,  DONALD NEUBERT TIMOTHY

IPC: A61K20090101 ,  A61K31/517 ,  A61K31/5377 ,  A61P20090101 ,  A61P25/00 ,  A61P29/00 ,  C07D20090101 ,  C07D239/70 ,  C07D239/91 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/12 ,  C07D413/02 ,  C07D471/04 ,  C07D495/04

Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.