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公开(公告)号：SI3354650T1
公开(公告)日：2022-06-30
申请号：SI200932162
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： KAY DAVID , CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/00 , A61K31/00 , A61P35/00 , C07D401/00 , C07D403/00 , C07D409/00 , C07D417/00 , C07D471/00
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公开(公告)号：AU2018201363C1
公开(公告)日：2020-06-18
申请号：AU2018201363
申请日：2018-02-26
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , YOUNG STEPHEN , REAPER PHILIP MICHAEL , VIRANI ANISA NIZARALI
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: Abstract The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; me thods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermedia tes fo r the prepara tion of the com pound s of this inve ntion; an d method s of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the com parative evaluation of n ew kin ase inhibitors. The compo un ds of this invention have formula (I):whereir the variables are as defined herein
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公开(公告)号：DK2376485T3
公开(公告)日：2018-03-12
申请号：DK09798991
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
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公开(公告)号：AU2016222396A1
公开(公告)日：2016-10-13
申请号：AU2016222396
申请日：2016-08-31
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , YOUNG STEPHEN , REAPER PHILIP MICHAEL , VIRANI ANISA NIZARALI
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I): wherein the variables are as defined herein. N (L)n-R'
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公开(公告)号：AU2009327357B2
公开(公告)日：2016-06-16
申请号：AU2009327357
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in
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Patent Agency Ranking
公开(公告)号：MX2013000103A
公开(公告)日：2013-06-13
申请号：MX2013000103
申请日：2011-06-23
Applicant: VERTEX PHARMA
Inventor： FRAYSSE DAMIEN , PINDER JOANNE , MACCORMICK SOMHAIRLE , REAPER PHILIP MICHAEL , DURRANT STEVEN JOHN , CHERRIER JEAN-DAMIEN , KNEGTEL RONALD MARCELLUS ALPHONSUS , VIRANI ANIZA NIZARALI
IPC: C07D487/04 , A61K31/4985 , A61P35/00 , C07D519/00
Abstract: La presente invención se relaciona con compuestos de pirrolopirazinas útiles como inhibidores de proteína cinasa ATR. Además, la invención se refiere a composiciones farmacéuticamente aceptables que comprenden los compuestos de esta invención; métodos para tratar diversas enfermedades, trastornos y afecciones con los compuestos de esta invención; procesos para preparar los compuestos de esta invención; intermedios para la preparación de los compuestos de esta invención y métodos para usar los compuestos en aplicaciones in vitro, tal como el estudio de cinasas en fenómenos biológicos y patológicos; el estudio de vías de transducción de señales intracelulares mediadas por tales cinasas y la evaluación comparativa de nuevos inhibidores de cinasas. Los compuestos de esta invención tienen la fórmula I: (fórmula) donde las variables son tal como se describen en la presente.
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公开(公告)号：HRP20220581T1
公开(公告)日：2022-06-10
申请号：HRP20220581
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
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公开(公告)号：AU2018201363B2
公开(公告)日：2020-02-20
申请号：AU2018201363
申请日：2018-02-26
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , YOUNG STEPHEN , REAPER PHILIP MICHAEL , VIRANI ANISA NIZARALI
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: Abstract The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; me thods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermedia tes fo r the prepara tion of the com pound s of this inve ntion; an d method s of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the com parative evaluation of n ew kin ase inhibitors. The compo un ds of this invention have formula (I):whereir the variables are as defined herein
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公开(公告)号：CY1120002T1
公开(公告)日：2018-12-12
申请号：CY181100268
申请日：2018-03-02
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: Ηπαρούσαεφεύρεσηαναφέρεταισεενώσειςπυραζίνηςχρήσιμεςωςαναστολείςκινάσηςπρωτεΐνης ATR. Ηεφεύρεσηαναφέρεται, επίσης, σεφαρμακευτικώςαποδεκτέςσυνθέσειςπουπεριέχουντιςενώσειςαυτήςτηςεφεύρεσης, μεθόδουςθεραπευτικήςαγωγήςδιαφόρωνασθενειών, διαταραχώνκαικαταστάσεων, μεχρήσητωνενώσεωναυτήςτηςεφεύρεσης, διαδικασίεςγιατηνπαρασκευήτωνενώσεωναυτήςτηςεφεύρεσης, ενδιάμεσαγιατηνπαρασκευήτωνενώσεωναυτήςτηςεφεύρεσηςκαιμεθόδουςχρήσηςτωνενώσεωνσε in vitro εφαρμογές, όπωςη μελέτηκινασώνσεβιολογικάκαιπαθολογικάφαινόμενα, ημελέτηοδώνμεταγωγήςενδοκυτταρικώνσημάτωνπουδιαμεσολαβείταιαπότέτοιεςκινάσεςκαιτησυγκριτικήαξιολόγησηνέωναναστολέωνκινάσης. Οιενώσειςαυτήςτηςεφεύρεσηςέχουντύπο (I): όπουοιμεταβλητέςείναιόπωςορίζονταιστοπαρόν.
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公开(公告)号：RS56995B1
公开(公告)日：2018-05-31
申请号：RSP20180262
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
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