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公开(公告)号：HRP20241695T1
公开(公告)日：2025-02-14
申请号：HRP20241695
申请日：2020-12-04
Applicant: VERTEX PHARMA
Inventor： DURRANT STEVEN JOHN , AHMAD NADIA , BECK ELIZABETH MARY , CARVALHO MEIRELES LIDIO , CHUDYK EWA IWONA , ETXEBARRIA JARDI GORKA , GALAN BHAIRAVI , HADIDA RUAH SARA S , HURLEY DENNIS JAMES , KNEGTEL RONALD MARCELLUS , NEUBERT TIMOTHY DONALD , PINDER JOANNE LOUISE , PONTILLO JOSEPH , PULLIN ROBERT , SCHMIDT YVONNE , SHAW DAVID MATTHEW , SKERRATT SARAH , STAMOS DEAN , THOMSON STEPHEN ANDREW , VIRANI ANISA NIZARALI , WRAY CHRISTOPHER
IPC: C07D405/12 , A61K31/443 , A61P29/00 , C07D405/14
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公开(公告)号：SI3354650T1
公开(公告)日：2022-06-30
申请号：SI200932162
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： KAY DAVID , CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/00 , A61K31/00 , A61P35/00 , C07D401/00 , C07D403/00 , C07D409/00 , C07D417/00 , C07D471/00
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公开(公告)号：AU2018201363C1
公开(公告)日：2020-06-18
申请号：AU2018201363
申请日：2018-02-26
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , YOUNG STEPHEN , REAPER PHILIP MICHAEL , VIRANI ANISA NIZARALI
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: Abstract The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; me thods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermedia tes fo r the prepara tion of the com pound s of this inve ntion; an d method s of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the com parative evaluation of n ew kin ase inhibitors. The compo un ds of this invention have formula (I):whereir the variables are as defined herein
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公开(公告)号：DK2376485T3
公开(公告)日：2018-03-12
申请号：DK09798991
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
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公开(公告)号：AU2016222396A1
公开(公告)日：2016-10-13
申请号：AU2016222396
申请日：2016-08-31
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , YOUNG STEPHEN , REAPER PHILIP MICHAEL , VIRANI ANISA NIZARALI
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I): wherein the variables are as defined herein. N (L)n-R'
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Patent Agency Ranking
公开(公告)号：AU2009327357B2
公开(公告)日：2016-06-16
申请号：AU2009327357
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in
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公开(公告)号：PL4069691T3
公开(公告)日：2025-01-27
申请号：PL20825397
申请日：2020-12-04
Applicant: VERTEX PHARMA
Inventor： DURRANT STEVEN JOHN , AHMAD NADIA , BECK ELIZABETH MARY , CARVALHO MEIRELES LIDIO , CHUDYK EWA IWONA , ETXEBARRIA JARDI GORKA , GALAN BHAIRAVI , HADIDA RUAH SARA S , HURLEY DENNIS JAMES , KNEGTEL RONALD MARCELLUS , NEUBERT TIMOTHY DONALD , PINDER JOANNE LOUISE , PONTILLO JOSEPH , PULLIN ROBERT , SCHMIDT YVONNE , SHAW DAVID MATTHEW , SKERRATT SARAH , STAMOS DEAN , THOMSON STEPHEN ANDREW , VIRANI ANISA NIZARALI , WRAY CHRISTOPHER
IPC: C07D405/12 , A61K31/443 , A61P29/00 , C07D405/14
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公开(公告)号：HRP20220581T1
公开(公告)日：2022-06-10
申请号：HRP20220581
申请日：2009-12-18
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
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公开(公告)号：AU2018201363B2
公开(公告)日：2020-02-20
申请号：AU2018201363
申请日：2018-02-26
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , YOUNG STEPHEN , REAPER PHILIP MICHAEL , VIRANI ANISA NIZARALI
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: Abstract The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; me thods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermedia tes fo r the prepara tion of the com pound s of this inve ntion; an d method s of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the com parative evaluation of n ew kin ase inhibitors. The compo un ds of this invention have formula (I):whereir the variables are as defined herein
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公开(公告)号：CY1120002T1
公开(公告)日：2018-12-12
申请号：CY181100268
申请日：2018-03-02
Applicant: VERTEX PHARMA
Inventor： CHARRIER JEAN-DAMIEN , DURRANT STEVEN , KAY DAVID , KNEGTEL RONALD , MACCORMICK SOMHAIRLE , MORTIMORE MICHAEL , O'DONNELL MICHAEL , PINDER JOANNE , RUTHERFORD ALISTAIR , VIRANI ANISA NIZARALI , YOUNG STEPHEN , REAPER PHILIP MICHAEL
IPC: C07D413/04 , A61K31/497 , A61P35/00 , C07D401/14 , C07D403/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D471/04
Abstract: Ηπαρούσαεφεύρεσηαναφέρεταισεενώσειςπυραζίνηςχρήσιμεςωςαναστολείςκινάσηςπρωτεΐνης ATR. Ηεφεύρεσηαναφέρεται, επίσης, σεφαρμακευτικώςαποδεκτέςσυνθέσειςπουπεριέχουντιςενώσειςαυτήςτηςεφεύρεσης, μεθόδουςθεραπευτικήςαγωγήςδιαφόρωνασθενειών, διαταραχώνκαικαταστάσεων, μεχρήσητωνενώσεωναυτήςτηςεφεύρεσης, διαδικασίεςγιατηνπαρασκευήτωνενώσεωναυτήςτηςεφεύρεσης, ενδιάμεσαγιατηνπαρασκευήτωνενώσεωναυτήςτηςεφεύρεσηςκαιμεθόδουςχρήσηςτωνενώσεωνσε in vitro εφαρμογές, όπωςη μελέτηκινασώνσεβιολογικάκαιπαθολογικάφαινόμενα, ημελέτηοδώνμεταγωγήςενδοκυτταρικώνσημάτωνπουδιαμεσολαβείταιαπότέτοιεςκινάσεςκαιτησυγκριτικήαξιολόγησηνέωναναστολέωνκινάσης. Οιενώσειςαυτήςτηςεφεύρεσηςέχουντύπο (I): όπουοιμεταβλητέςείναιόπωςορίζονταιστοπαρόν.
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